Citric acid
RTECS #
GE7350000
CAS #
Updated
December 2017
Molecular Weight
192.14
Molecular Formula
C6H8O7
Synonyms
1,2,3-Propanetricarboxylic acid, 2-hydroxy-
2-Hydroxy-1,2,3-propanetricarboxylic acid
Aciletten
Anhydrous citric acid
beta-Hydroxytricarballylic acid
Citretten
Citric acid, anhydrous
Citro
Kyselina 2-hydroxy-1,2,3-propantrikarbonova (Czech)
Kyselina citronova (Czech)
NSC 30279
2-Hydroxy-1,2,3-propanetricarboxylic acid
Aciletten
Anhydrous citric acid
beta-Hydroxytricarballylic acid
Citretten
Citric acid, anhydrous
Citro
Kyselina 2-hydroxy-1,2,3-propantrikarbonova (Czech)
Kyselina citronova (Czech)
NSC 30279
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /rabbit | 750 µg/24H | severe | 85JCAE -,658,1986 |
skin /rabbit | 0.5 mL | moderate | HPV093 -,-,2001 |
skin /rabbit | 500 mg/24H | mild | 85JCAE -,658,1986 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/ela | Inhibitor Concentration (50 percent kill): 1.58 gm/L/24H | In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc. | FCTOD7 78,105,2015 |
In Vitro/embryo | Inhibitor Concentration (50 percent kill): 1.03 gm/L/24H | In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc. | TIVIEQ 29,289,2015 |
In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 20 mmol/L/24H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 3,189,1989 |
In Vitro/Human, lymphocyte | Inhibitor Concentration (30 percent kill): >200 mg/L/45H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | TIVIEQ 29,901,2015 |
In Vitro/Human, lymphocyte | Inhibitor Concentration (50 percent kill): >200 mg/L/45H | In Vitro Toxicity Studies: Other assays | TIVIEQ 29,901,2015 |
In Vitro/Human, skin | Inhibitor Concentration Low: 60 mg/well/10M | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 27,1476,2013 |
In Vitro/Non-mammalian species, fibroblast | Inhibitor Concentration (50 percent kill): 3.4 mmol/L/24H | In Vitro Toxicity Studies: Cell counting | TIVIEQ 7,537,1993 |
In Vitro/Rabbit, ocular | Inhibitor Concentration Low: 5 pph/5M | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 27,1855,2013 |
inhalation/guinea pig | lowest published toxic concentration: 115284 gm/m3/2M | Lung, Thorax, or Respiration: Cough Lung, Thorax, or Respiration: Other changes | JPHPH* 58,419,2007 |
inhalation/guinea pig | lowest published toxic concentration: 19214 gm/m3/10M | Lung, Thorax, or Respiration: Cough | EJPHAZ 528,158,2005 |
inhalation/guinea pig | lowest published toxic concentration: 100000 gm/m3 | Lung, Thorax, or Respiration: Cough | TOXID9 44,298,2005 |
inhalation/guinea pig | lowest published toxic concentration: 300000 gm/m3 | Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma | TOXID9 44,298,2005 |
inhalation/guinea pig | lowest published toxic concentration: 11528 gm/m3/3M | Lung, Thorax, or Respiration: Cough Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TXAPA9 202,18,2005 |
inhalation/guinea pig | lowest published toxic concentration: 20 pph/10M | Lung, Thorax, or Respiration: Cough | BJPCBM 138,407,2003 |
inhalation/human | lowest published toxic concentration: 87328 gm/m3/0.0083M | Lung, Thorax, or Respiration: Cough | JPHPH* 58,531,2007 |
inhalation/monkey | lowest published toxic concentration: 2.5 pph/5M | Lung, Thorax, or Respiration: Cough | TOXID9 44,298,2005 |
inhalation/rat | lowest published toxic concentration: 180 mg/m3 | Lung, Thorax, or Respiration: Other changes Liver: Liver function tests impaired Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | TOVEFN (5),9,1994 |
intraperitoneal/mouse | lethal dose (50 percent kill): 903 mg/kg | TXCYAC 62,203,1990 | |
intraperitoneal/rat | lethal dose (50 percent kill): 290 mg/kg | TOVEFN (5),9,1994 | |
intraperitoneal/rat | lethal dose (16 percent kill): 197 mg/kg | TOVEFN (5),9,1994 | |
intraperitoneal/rat | lowest published lethal dose: 382 mg/kg | TOVEFN (5),9,1994 | |
intratracheal/guinea pig | lowest published toxic dose: 3 mg/kg | Lung, Thorax, or Respiration: Cough | JPHSC* 101,118,2006 |
intratracheal/guinea pig | lowest published toxic dose: 118 gm/kg | Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma Lung, Thorax, or Respiration: Sputum Biochemical: Metabolism (intermediary): Histamines (including liberation not immunochemical in origin) | TXAPA9 206,343,2005 |
intravenous/Dog | lowest published toxic dose: 64 mg/kg/30M | Cardiac: Change in rate Nutritional and Gross Metabolic: Changes in: Ca Nutritional and Gross Metabolic: Changes in: Other metals | CLNUT* 25,984,2006 |
intravenous/Dog | lowest published toxic dose: 63 mg/kg/1H | Cardiac: EKG changes not diagnostic of above Nutritional and Gross Metabolic: Changes in: Ca Nutritional and Gross Metabolic: Changes in: Other metals | CLNUT* 25,984,2006 |
intravenous/Dog | lowest published toxic dose: 256 mg/kg/2H | Cardiac: EKG changes not diagnostic of above Gastrointestinal: Nausea or vomiting Nutritional and Gross Metabolic: Changes in: Ca | CLNUT* 25,984,2006 |
intravenous/Dog | lowest published toxic dose: 256 mg/kg/1H | Cardiac: Arrythmias (indlucing changes in conduction) Gastrointestinal: Changes in structure or function of salivary glands Gastrointestinal: Nausea or vomiting | CLNUT* 25,984,2006 |
intravenous/mouse | lethal dose (50 percent kill): 42 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Cyanosis Gastrointestinal: Changes in structure or function of salivary glands | JPETAB 94,65,1948 |
intravenous/rabbit | lethal dose (50 percent kill): 330 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Cyanosis Gastrointestinal: Changes in structure or function of salivary glands | JPETAB 94,65,1948 |
oral/mouse | lethal dose (16 percent kill): 5440 mg/kg | TOVEFN (5),9,1994 | |
oral/mouse | lethal dose (50 percent kill): 7280 mg/kg | TOVEFN (5),9,1994 | |
oral/mouse | lowest published lethal dose: 9080 mg/kg | TOVEFN (5),9,1994 | |
oral/mouse | lethal dose (50 percent kill): 5040 mg/kg | Lung, Thorax, or Respiration: Other changes Musculoskeletal: Other changes | TAKHAA 30,25,1971 |
oral/rabbit | lowest published lethal dose: 7 gm/kg | Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Behavioral: Muscle contraction or spasticity | IECHAD 15,628,1923 |
oral/rat | lethal dose (50 percent kill): 3 gm/kg | OYYAA2 43,561,1992 | |
oral/rat | lethal dose (16 percent kill): 5000 mg/kg | TOVEFN (5),9,1994 | |
oral/rat | lowest published lethal dose: 8300 mg/kg | TOVEFN (5),9,1994 | |
oral/rat | lethal dose (50 percent kill): 11700 mg/kg | Behavioral: Ataxia Cardiac: Change in rate Lung, Thorax, or Respiration: Respiratory depression | HPV093 -,-,2001 |
subcutaneous/mouse | lethal dose (50 percent kill): 2700 mg/kg | Lung, Thorax, or Respiration: Other changes Musculoskeletal: Other changes | TAKHAA 30,25,1971 |
subcutaneous/rat | lethal dose (50 percent kill): 5500 mg/kg | Lung, Thorax, or Respiration: Other changes Musculoskeletal: Other changes | TAKHAA 30,25,1971 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | lowest published toxic dose: 9.3 gm/kg/15D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | GISAAA -,65,1993 |
oral/rat | lowest published toxic dose: 18.6 gm/kg/30D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | GISAAA -,65,1993 |
oral/rat | lowest published toxic dose: 12.6 gm/kg/21D- intermittent | Immunological Including Allergic: Decreased immune response | GISAAA -,65,1993 |
Reviews
Organization | Standard | Reference |
---|---|---|
TOXICOLOGY REVIEW | FTRPAE 115,155,2016 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | RED Completed | RBREV* -,302,1998 |
Occupational Exposure Limit-RUSSIA | short term exposure limit 1 mg/m3, JUN2003 |
NIOSH Documentation and Surveillance
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health