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Registry of Toxic Effects of Chemical Substances (RTECS)

Chlorine fluoride

RTECS #

FO2800000

CAS #

7790-91-2

Updated

September 2013

Molecular Weight

92.45

Molecular Formula

ClF3

Synonyms

Chlorine trifluoride
Chlorine trifluoride (ACGIH:OSHA)
Chlorotrifluoride
Trifluorure de chlore (French)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /Dog 21 ppm/12H- intermittentAMIHAB 12,515,1955
eye /rat 21 ppm/12H- intermittentAMIHAB 12,515,1955

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 1800 mg/m3/5MEye: Lacrimation

Eye: Corneal damage
VCVN5* -,386,1989
inhalation/Dog Lowest published lethal concentration: 360 mg/m3/4HVCVN5* -,386,1989
inhalation/Dog lowest published toxic concentration: 1800 mg/m3/2MOlfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVN5* -,386,1989
inhalation/human Lowest published lethal concentration: 50 ppm34ZIAG -,651,1966
inhalation/mammal (species unspecified) lowest published toxic concentration: 80 mg/m3/10MLung, Thorax, or Respiration: CoughVCVN5* -,386,1989
inhalation/monkey lethal concentration (50 percent kill): 230 ppm/1HBehavioral: Muscle weakness

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Cyanosis
AMRL** TR-70-77,1970
inhalation/mouse lethal concentration (50 percent kill): 178 ppm/1HLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Cyanosis
AMRL** TR-70-77,1970
inhalation/rabbit lowest published toxic concentration: 1800 mg/m3/2MOlfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVN5* -,386,1989
inhalation/rabbit Lowest published lethal concentration: 360 mg/m3/4HVCVN5* -,386,1989
inhalation/rabbit lowest published toxic concentration: 1800 mg/m3/5MEye: Lacrimation

Eye: Corneal damage
VCVN5* -,386,1989
inhalation/rat lethal concentration (50 percent kill): 299 ppm/1HTXAPA9 42,417,1977
inhalation/rat Lowest published lethal concentration: 3000 mg/m3/15MVCVN5* -,385,1989
inhalation/rat Lowest published lethal concentration: 1500 mg/m3/35MVCVN5* -,386,1989

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 5150 ppb/6H/6W- intermittentEye: Corneal damage

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHAB 12,515,1955
inhalation/Dog lowest published toxic concentration: 1170 ppb/6H/26W- intermittentEye: Lacrimation

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHAB 13,340,1956
inhalation/Dog lowest published toxic concentration: 20 mg/m3/6H/6W- intermittentLung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Acute pulmonary edema

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN5* -,386,1989
inhalation/mammal (species unspecified) lowest published toxic concentration: 4 mg/m3/6H/26W- intermittentEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVN5* -,386,1989
inhalation/mammal (species unspecified) lowest published toxic concentration: 4 mg/m3/6H/8W- intermittentLung, Thorax, or Respiration: Other changesVCVN5* -,386,1989
inhalation/mammal (species unspecified) lowest published toxic concentration: 2 mg/m3/17W- intermittentBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Musculoskeletal: Other changes
STGNBT -,239,1999
inhalation/rat lowest published toxic concentration: 20 mg/m3/6H/6W- intermittentLung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Acute pulmonary edema

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN5* -,386,1989
inhalation/rat lowest published toxic concentration: 5150 ppb/6H/6W- intermittentLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Gastrointestinal: Changes in structure or function of salivary glands

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHAB 12,515,1955
inhalation/rat lowest published toxic concentration: 1170 ppb/6H/26W- intermittentBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHAB 13,340,1956

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-ceiling concentration 0.1 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2.5 mg(F)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWTXAPA9 27,527,1974

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARDair-ceiling concentration 0.1 ppm (0.4 mg/m3)DTLWS* 3,11,1972
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAceiling concentration 0.1 ppm (0.38 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2.5 mg(F)/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 ppm (0.4 mg/m3);KZW 0.2 ppm (0.8 mg/m3), 2007
Occupational Exposure Limit-BELGIUMshort term exposure limit 0.1 ppm (0.39 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMtime-weighted average 2.5 mg(F)/m3, MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 0.1 ppm (0.4 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 2.5 mg(F)/m3, JUN2000
Occupational Exposure Limit-FINLANDshort term exposure limit 0.1 ppm (0.38 mg/m3), NOV2011
Occupational Exposure Limit-FINLANDtime-weighted average 2.5 mg(F)/m3, NOV2011
Occupational Exposure Limit-FRANCEVLE 0.4 mg/m3, FEB2006
Occupational Exposure Limit-GERMANYMAK 1 mg(F)/m3, inhal, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 2.5 mg(F)/m3, short term exposure limit 10 mg(F)/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDshort term exposure limit 0.1 ppm (0.4 mg/m3), NOV2011
Occupational Exposure Limit-KOREAceiling concentration 0.1 ppm (0.4 mg/m3), 2006
Occupational Exposure Limit-MEXICOpeak 0.1 ppm (0.4 mg/m3), 2004
Occupational Exposure Limit-MEXICOtime-weighted average 2.5 mg(F)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDceiling concentration 0.1 ppm (0.38 mg/m3), JAN2002
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2.5 mg(F)/m3, JAN2002
Occupational Exposure Limit-PERUshort term exposure limit 0,1 ppm (0,38 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 1 mg(HF)/m3, MAC(short term exposure limit) 3 mg(HF)/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDceiling concentration 0.1 ppm (0.4 mg/m3), JAN2011
Occupational Exposure Limit-SWITZERLANDMAK-week 1 mg(F)/m3, KZG-week 4 mg(F)/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.1 ppm (0.4 mg/m3), JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-C 0.4 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.1 ppm (0.4 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 2.5 mg(F)/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)ceiling concentration 0.1 ppm (0.4 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)ceiling concentration 0.1 ppm (0.4 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)ceiling concentration 0.1 ppm (0.4 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)ceiling concentration 0.1 ppm (0.4 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLORINE TRIFLUORIDE-airceiling concentration 0.1 ppmNIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974Hazard Code 18050; Number of Industries 1; Total Number of Facilities 11; Number of Occupations 3; Total Number of Employees Exposed 357

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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