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Registry of Toxic Effects of Chemical Substances (RTECS)

Cadmium sulfate (1:1)

RTECS #

EV2700000

CAS #

10124-36-4; 31119-53-6; 62642-07-3

Updated

October 2017

Molecular Weight

208.46

Molecular Formula

O4S·Cd

Synonyms

Cadmium sulfate
Cadmium sulphate
Sulphuric acid, cadmium salt (1:1)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster1 µmol/LMUREAV 265,45,1992
DNA Damagefibroblast/human0.033 µmol/L/2HMUREAV 498,47,2001
DNA Damageliver/other fish50 µmol/L/24HTXAPA9 272,443,2013
DNA Damagelung/rat31.2 µmol/L/20HMUREAV 605,94,2006
DNA Damagelung/human7.8 µmol/L/20HMUREAV 605,94,2006
DNA Damageoral/rat140 mg/kgMUREAV 605,94,2006
DNA Damageliver/rat5 µmol/L/3HMUREAV 629,49,2007
DNA Damage/Neurospora crassa10 µmol/LMUREAV 405,29,1998
DNA Damagelymphocyte/human500 µmol/LEMMUEG 23,299,1994
DNA Damageliver/rat30 µmol/LMUREAV 113,357,1983
DNA repair/Escherichia coli50 µg/wellMUREAV 133,161,1984
DNA repair/Bacillus subtilis5 mmol/LMUREAV 77,109,1980
micronucleus testintraperitoneal/mouse4300 µg/kgGWZHEW 12,77,1986
micronucleus testovary/hamster1.11 µmol/L/24H (-enzymatic activation step)MUREAV 630,1,2007
micronucleus testovary/hamster2.22 µmol/L/3H (+enzymatic activation step)MUREAV 751,1,2013
micronucleus testfibroblast/human0.033 µmol/L/24HMUREAV 490,99,2001
mutation in mammalian somatic cellslymphocyte/mouse150 µg/LJTEHD6 9,367,1982
other mutation test systemsovary/hamster1 µmol/LMUREAV 265,45,1992
sex chromosome loss and nondisjunctionlung/human67 nmol/LMUREAV 469,35,2000

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 5150 µg/kg (9D pregnant)Reproductive: Other effects to embryo or fetusTJADAB 32,407,1985
intraperitoneal/mouse 5150 µg/kg (9D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TJADAB 29,427,1984
intraperitoneal/mouse 3 mg/kg (9D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemTJADAB 27,54A,1983
intraperitoneal/mouse 1030 µg/kg (9D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TJADAB 29,427,1984
intraperitoneal/mouse 2570 µg/kg (9D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTJADAB 29,427,1984
intraperitoneal/hamster 2800 µg/kg (8D pregnant)Reproductive: Other developmental abnormalitiesTJADAB 29(2),30A,1984
intravenous/hamster 2 mg/kg (8D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Central nervous system
BECTA6 22,175,1979
intravenous/hamster 2 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Homeostasis

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
BECTA6 22,175,1979
intravenous/hamster 2 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Eye, ear
EXPEAM 25,56,1969
intravenous/hamster 2 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Homeostasis
ENVRAL 6,95,1973
oral/rat 35230 mg/kg (1-19D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Maternal- fetal exchange
GISAAA 50(8),11,1985
oral/rat 35230 mg/kg (1-19D pregnant)Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
GISAAA 50(8),11,1985
parenteral/mouse 28 µg/kg (12D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
IGSBAL 92,65,1976

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Mouse, embryo Inhibitor Concentration Low: 0.7 µmol/LReproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TIVIEQ 4,57,1990
In Vitro/mpeInhibitor Concentration Low: 25 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TOLED5 198,152,2010
In Vitro/mpeInhibitor Concentration Low: 10 µmol/L/10MIn Vitro Toxicity Studies: Other assaysTOLED5 198,152,2010
In Vitro/mpeInhibitor Concentration Low: 10 µmol/L/24HIn Vitro Toxicity Studies: Other assaysTOLED5 198,152,2010
In Vitro/Non-mammalian species, liver Inhibitor Concentration (50 percent kill): 99.6 µmol/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXAPA9 272,443,2013
intramuscular/rat lowest published toxic dose: 1 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
BCLPT* 94,112,2004
intraperitoneal/mouse lethal dose (50 percent kill): 6879 µg/kgCOREAF 256,1043,1963
oral/Dog lowest published lethal dose: 105 mg/kgEQSSDX 1,1,1975
oral/mouse lethal dose (50 percent kill): 47 mg/kgVCVN1* -,164,1988
oral/rat lethal dose (50 percent kill): 280 mg/kg41HTAH -,14,1978
subcutaneous/Dog lowest published lethal dose: 27 mg/kgEQSSDX 1,1,1975
subcutaneous/frog lowest published lethal dose: 105 mg/kgHBAMAK 4,1317,1935

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intramuscular/rat lowest published toxic dose: 122 mg/kg/17W- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
BCLPT* 94,112,2004
intraperitoneal/rat lowest published toxic dose: 3.6 mg/kg/2D- intermittentEndocrine: Evidence of thyroid hypofunction

Biochemical: Metabolism (intermediary): Other proteins
EXMPA6 55,97,1991
oral/rat lowest published toxic dose: 315 mg/kg/3W- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
FCTOD7 46,3604,2008

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.002 mg(Cd)/m3 (resp)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Suspected human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 2,74,1973
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 11,39,1976
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 58,119,1993
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 58,119,1993
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 100C,141,2012
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 100C,141,2012
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 58,119,1993
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 100C,141,2012
TOXICOLOGY REVIEWADTEAS 5,51,1972
TOXICOLOGY REVIEWFCTXAV 9,105,1971
TOXICOLOGY REVIEWPEXTAR 12,102,1969
TOXICOLOGY REVIEW43QNAO 2,743,1981
TOXICOLOGY REVIEWMUTAEX 14,5,1999
TOXICOLOGY REVIEWEMMUEG 43,36,2004
TOXICOLOGY REVIEWENTOX* -,375,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWNETEEC 29,425,2007
TOXICOLOGY REVIEWHBTME* ,445,2007
TOXICOLOGY REVIEWHBTME* ,177,2007
TOXICOLOGY REVIEWHUTOX* -,515,1996
TOXICOLOGY REVIEWMUTAEX 23,271,2008
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWMUREAV 769,34,2014
TOXICOLOGY REVIEWFCTOD7 56,406,2013
TOXICOLOGY REVIEWMUREAV 802,1,2016
TOXICOLOGY REVIEWMUREAV 770,119,I2

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.2 mg(Cd)/m3DTLVS* 3,34,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.05 mg(Cd)/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.01 mg(Cd)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.002 mg(Cd)/m3 (resp. dust), Carcinogen, MAR2002
Occupational Exposure Limit-BELGIUMtime-weighted average 0.01 mg(Cd)/m3 (inhal. dust), Carcinogen, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.005 mg(Cd)/m3 (fume, dust), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.02 mg(Cd)/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.05 mg(Cd)/m3, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 0.015 mg(Cd)/m3, short term exposure limit 0.06 mg(Cd)/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.05 mg(Cd)/m3, 1 carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.05 mg(Cd)/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.002 mg(Cd)/m3 (inhalable), 2004
Occupational Exposure Limit-MEXICOtime-weighted average 0.01 mg(Cd)/m3 (total dust), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.01 mg(Cd)/m3 (inspirable dust), JAN2002
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.002 mg(Cd)/m3 (respirable dust), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.05 mg(Cd)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) dust 0.04 mg(Cd)/m3, MAC(short term exposure limit) dust 0.2 mg(Cd)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) fume 0.02 mg(Cd)/m3, MAC(short term exposure limit) fume 0.05 mg(Cd)/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.01 mg(Cd)/m3, short term exposure limit 0.05 mg(Cd)/m3, Carcinogen, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.02 mg(Cd)/m3 (total dust), Carcinogen, JUN2005
Occupational Exposure Limit-SWEDENtime-weighted average 0.005 mg(Cd)/m3 (resp. dust), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.015 mg(Cd)/m3, carc 2, inhal, skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.2 mg(Cd)/m3, short term exposure limit 0.5 mg(Cd)/m3, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.005 mg(Cd)/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.2 mg(Cd)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.2 mg(Cd)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.025 mg(Cd)/m3, carc, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CADMIUM, dust and fume-airCarcinogen lowest feasible conc.NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 80247; Number of Industries 5; Total Number of Facilities 79; Number of Occupations 4; Total Number of Employees Exposed 1313; Total Number of Female Employees Exposed 172
National Occupational Hazard Survey 1974Hazard Code 80247; Number of Industries 5; Total Number of Facilities 1041; Number of Occupations 5; Total Number of Employees Exposed 15328

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
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