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Registry of Toxic Effects of Chemical Substances (RTECS)

Cadmium oxide

RTECS #

EV1925000

CAS #

1306-19-0

Updated

October 2017

Molecular Weight

128.40

Molecular Formula

CdO

Synonyms

Cadmium monoxide
Cadmium oxide (ACGIH)
Cadmium oxide fume
Kadmu tlenek (Polish)
NCI-C02551

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 183 µg/m3/5H (21W prior to copulation/1-20D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TOLED5 22,53,1984
inhalation/rat 23 µg/m3/5H (21W prior to copulation/1-20D pregnant)Reproductive: Effects on newborn: BehavioralTOLED5 22,53,1984
inhalation/rat 91 µg/m3 (1-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)GTPZAB 31(8),25,1987
inhalation/rat 2 mg/m3/6H (4-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTPTR* NIH-95-3388
inhalation/rat 16 µg/m3/24H (1-21D pregnant)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)GISAAA 46(10),13,1981
inhalation/mouse 2 mg/m3/6H (4-17D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTPTR* NIH-95-3388
inhalation/mouse 500 µg/m3/6H (4-17D pregnant)Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
NTPTR* NIH-95-3388
oral/rat 21640 µg/kg (1-19D pregnant)Reproductive: Effects on embryo or fetus: Maternal- fetal exchange

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
GISAAA 50(8),11,1985
oral/rat 21640 µg/kg (1-19D pregnant)Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
GISAAA 50(8),11,1985

Tumorigenic Data and References

Route/OrganismDoseEffectReference
subcutaneous/rat lowest published toxic dose: 90 mg/kgTumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application
BJCAAI 20,190,1966

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lethal concentration (50 percent kill): 4 gm/m3/10M85PDAD -,67,1978
inhalation/guinea pig lethal concentration (50 percent kill): 3500 mg/m3/10M85PDAD -,67,1978
inhalation/human Lowest published lethal concentration: 5 mg/m3/8HHBTME* -,445,2007
inhalation/human lowest published toxic concentration: 8630 µg/m3/5HYAKUD5 22,455,1980
inhalation/man lowest published toxic concentration: 500 µg/m3/5Y- intermittentOlfaction: Change in sensation of smell

Kidney, Ureter, and Bladder: Proteinuria
QJMEA7 38,425,1969
inhalation/man lowest published toxic concentration: 40 µg/m3Cardiac: Change in rate

Vascular: BP elevation not characterized in autonomic section

Kidney, Ureter, and Bladder: Other changes
GISAAA 45(10),22,1980
inhalation/monkey lethal concentration (50 percent kill): 1500 mg/m3/10M85PDAD -,67,1978
inhalation/mouse lethal concentration (50 percent kill): 250 mg/m3/2H85PDAD -,67,1978
inhalation/rabbit lethal concentration (50 percent kill): 2500 mg/m3/10M85PDAD -,67,1978
inhalation/rat lethal concentration (50 percent kill): 45 mg/m3/1HVCVN1* -,164,1988
inhalation/rat Lowest published lethal concentration: 60 µg/m3/1HLung, Thorax, or Respiration: Fibrosing alveolitis

Lung, Thorax, or Respiration: Acute pulmonary edema
TOLED5 2,323,1978
intraperitoneal/rat lethal dose (50 percent kill): 12 mg/kgZDKAA8 38(9),18,1978
intravenous/rat lethal dose (50 percent kill): 25 mg/kg85PDAD -,67,1978
oral/mammal (species unspecified) lethal dose (50 percent kill): 72 mg/kgHYSAAV 33(7-9),187,1968
oral/mouse lethal dose (50 percent kill): 67 mg/kgVCVN1* -,164,1988
oral/rat lethal dose (50 percent kill): 72 mg/kgYAKUD5 22,455,1980
subcutaneous/mouse lethal dose (50 percent kill): 94 mg/kg85PDAD -,67,1978

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 300 µg/m3/6H/2W- intermittentLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Changes in lung weight
NTPTR* NIH-95-3388
inhalation/mouse lowest published toxic concentration: 50 µg/m3/6H/13W- continuousLung, Thorax, or Respiration: Other changes

Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight
NTPTR* NIH-95-3388
inhalation/rat lowest published toxic concentration: 23 µg/m3/24H/20W- continuousKidney, Ureter, and Bladder: Proteinuria

Musculoskeletal: Osteoporosis

Nutritional and Gross Metabolic: Changes in: Ca
GISAAA 52(5),85,1987
inhalation/rat lowest published toxic concentration: 57 µg/m3/90D- continuousLung, Thorax, or Respiration: Changes in lung weight

Blood: Pigmented or nucleated red blood cells

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
ARTODN 40,231,1978
inhalation/rat lowest published toxic concentration: 300 µg/m3/6H/2W- intermittentCardiac: Changes in heart weight

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in bladder weight
NTPTR* NIH-95-3388
inhalation/rat lowest published toxic concentration: 2800 ng/kg/5H/1W- intermittentImmunological Including Allergic: Decrease in humoral immune responseTOXID9 72,293,2003
oral/Dog lowest published toxic dose: 0.5 mg/kg/2D- continuousBehavioral: Anorexia (human)

Gastrointestinal: Nausea or vomiting
TOLED5 135,S124,2002
oral/Dog lowest published toxic dose: 7 mg/kg/28D- continuousKidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 135,S124,2002
oral/Dog lowest published toxic dose: 0.75 mg/kg/3D- continuousBehavioral: Anorexia (human)

Gastrointestinal: Nausea or vomiting

Blood: Changes in erythrocyte (RBC) count
TOLED5 135,S124,2002
oral/Dog lowest published toxic dose: 1.75 mg/kg/7D- continuousBehavioral: Anorexia (human)

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Dehydration
TOLED5 135,S124,2002
oral/rat lowest published toxic dose: 156 µg/kg/26W- intermittentKidney, Ureter, and Bladder: Proteinuria

Blood: Other changes

Musculoskeletal: Other changes
GISAAA 52(6),70,1987

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.002 mg(Cd)/m3 (resp)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Suspected human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 2,74,1973
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 11,39,1976
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 58,119,1993
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 11,39,1976
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 58,119,1993
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 100C,141,2012
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 100C,141,2012
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 58,119,1993
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 100C,141,2012
TOXICOLOGY REVIEWFCTXAV 9,105,1971
TOXICOLOGY REVIEWPEXTAR 12,102,1969
TOXICOLOGY REVIEWAMPMAR 34,127,1973
TOXICOLOGY REVIEWMUREAV 566,21,2004
TOXICOLOGY REVIEWTOLED5 140-141,53,2003
TOXICOLOGY REVIEWENTOX* -,375,2005
TOXICOLOGY REVIEWHBTME* ,445,2007
TOXICOLOGY REVIEWHUTOX* -,515,1996
TOXICOLOGY REVIEWFCTOD7 49,2921,2011
TOXICOLOGY REVIEWMUREAV 770,119,I2

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.01 mg(Cd)/m3, Carcinogen, JUL2008
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.01 mg(Cd)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.002 mg(Cd)/m3 (resp. dust), Carcinogen, MAR2002
Occupational Exposure Limit-BELGIUMtime-weighted average 0.01 mg(Cd)/m3 (inhal. dust), Carcinogen, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.005 mg(Cd)/m3 (fume, dust), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.01 mg/m3, resp. dust, skin, NOV2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.02 mg(Cd)/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVLE 0.05 mg(Cd)/m3, C2 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARYceiling concentration 0.05 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit-HUNGARYtime-weighted average 0.015 mg(Cd)/m3, short term exposure limit 0.06 mg(Cd)/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.05 mg(Cd)/m3, 1 carc, MAY2012
Occupational Exposure Limit-KOREAceiling concentration 0.05 mg(Cd)/m3 (fume), 2006
Occupational Exposure Limit-KOREAtime-weighted average 0.05 mg(Cd)/m3, 2006
Occupational Exposure Limit-KOREAtime-weighted average 0.05 mg/m3 (production), 2006
Occupational Exposure Limit-MEXICOpeak 0.05 mg(Cd)/m3 (fume), 2004
Occupational Exposure Limit-MEXICOtime-weighted average 0.002 mg(Cd)/m3 (inhalable), 2004
Occupational Exposure Limit-MEXICOtime-weighted average 0.01 mg(Cd)/m3 (total dust), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.002 mg(Cd)/m3 (respirable dust), JAN2002
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.01 mg(Cd)/m3 (inspirable dust), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.05 mg(Cd)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) fume 0.02 mg(Cd)/m3, MAC(short term exposure limit) fume 0.05 mg(Cd)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) dust 0.04 mg(Cd)/m3, MAC(short term exposure limit) dust 0.2 mg(Cd)/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.01 mg(Cd)/m3, short term exposure limit 0.05 mg(Cd)/m3, Carcinogen, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.02 mg(Cd)/m3 (total dust), Carcinogen, JUN2005
Occupational Exposure Limit-SWEDENtime-weighted average 0.005 mg(Cd)/m3 (resp. dust), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.002 mg/m3, carc 2, resp, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3 (fume), JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.005 mg(Cd)/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.1 mg/m3 (fume), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.1 mg/m3 (fume), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.025 mg(Cd)/m3;short term exposure limit 0.05 mg(Cd)/m3 (fume), carc, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CADMIUM, dust and fume-airCarcinogen lowest feasible conc.NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M1554; Number of Industries 27; Total Number of Facilities 556; Number of Occupations 31; Total Number of Employees Exposed 15727; Total Number of Female Employees Exposed 4850
National Occupational Hazard Survey 1974Hazard Code M1554; Number of Industries 37; Total Number of Facilities 1127; Number of Occupations 28; Total Number of Employees Exposed 10110

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Cadmium and compounds, as Cd, 7048
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
NTP Toxicity studies, RPT# TOX-39, October 2000
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