Butyric acid

RTECS #

ES5425000

CAS #

107-92-6
See: NMAM or OSHA Methods

Updated

December 2016

Molecular Weight

88.12

Molecular Formula

C₄H₈O₂

Synonyms

1-Propanecarboxylic acid
Butanic acid
Butanoic acid
Buttersaeure (German)
Ethylacetic acid
Kyselina maselna (Czech)
n-Butyric acid
Propylformic acid

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /rabbit	500 mg open irritation test	moderate	UCDS** 4/10/1968
skin /rabbit	20 mg/24H	moderate	85JCAE -,306,1986

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
DNA Damage	HeLa cell/human	3 mmol/L	CELLB5 12,855,1977
DNA Damage	fibroblast/chicken	2 mmol/L	CELLB5 12,855,1977
DNA inhibition	lymphocyte/human	4 mmol/L	HAONDL 2,381,1984

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, colon tumor	Inhibitor Concentration Low: 40 mmol/L/48H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	FCTOD7 62,892,2013
In Vitro/Human, colon tumor	Inhibitor Concentration Low: 25 mmol/L/48H	In Vitro Toxicity Studies: Cell growth: Colony formation	FCTOD7 62,892,2013
In Vitro/Human, colon tumor	Inhibitor Concentration Low: 50 mmol/L/4H	In Vitro Toxicity Studies: Apoptosis in vitro	FCTOD7 62,892,2013
In Vitro/Human, liver tumor	Inhibitor Concentration (50 percent kill): 39 mmol/L/24H	In Vitro Toxicity Studies: Cell protein synthesis	TIVIEQ 3,189,1989
In Vitro/Human, skin	Inhibitor Concentration Low: 0.08 mL/well/3M	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 28,616,2014
inhalation/mouse	Lethal concentration: >500 mg/m³	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi	GISAAA 23(5),31,1958
inhalation/rabbit	lethal concentration (50 percent kill): >40 gm/m³		ENTOX* -,368,2005
inhalation/rat	Lethal concentration: >500 mg/m³	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi	TPKVAL 4,19,1962
intraperitoneal/mouse	lethal dose (50 percent kill): 3180 mg/kg		JPPMAB 21,85,1969
intravenous/mouse	lethal dose (50 percent kill): 800 mg/kg	Behavioral: Convulsions or effect on seizure threshold	APTOA6 18,141,1961
ocular/rabbit	lowest published toxic dose: 100 pph	Eye: Lacrimation Eye: Conjunctiva irritation Eye: Corneal damage	TPKVAL 4,19,1962
oral/mouse	lethal dose (50 percent kill): 1250 mg/kg		TPKVAL 9,27,1967
oral/mouse	lowest published lethal dose: 1000 mg/kg		TPKVAL 4,19,1962
oral/mouse	lowest published lethal dose: 500 mg/kg	Gastrointestinal: Necrotic changes Kidney, Ureter, and Bladder: Other changes Blood: Changes in spleen	TPKVAL 4,19,1962
oral/rat	lowest published lethal dose: 1000 mg/kg	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi	TPKVAL 4,19,1962
oral/rat	lethal dose (50 percent kill): 1500 mg/kg		TPKVAL 9,27,1967
skin/rabbit	lethal dose (50 percent kill): 530 mg/kg		ENTOX* -,368,2005
skin/rabbit	lethal dose (50 percent kill): 530 µL/kg		UCDS** 4/10/1968
subcutaneous/mouse	lethal dose (50 percent kill): 3180 mg/kg		JPPMAB 21,85,1969

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 0.4 gm/m³/2W- intermittent	Peripheral Nerve and Sensation: Recording from peripheral motor nerve	TPKVAL 4,19,1962
inhalation/rat	lowest published toxic concentration: 0.4 gm/m³/30D- intermittent	Lung, Thorax, or Respiration: Other changes	TPKVAL 4,19,1962
inhalation/rat	lowest published toxic concentration: 0.15 gm/m³/213D- intermittent	Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance Liver: Fatty liver degeneration Blood: Changes in spleen	TPKVAL 4,19,1962
oral/hamster	lowest published toxic dose: 14 gm/kg/7D- continuous	Gastrointestinal: Other changes	FCTOD7 29,367,1991
oral/mouse	lowest published toxic dose: 33600 mg/kg/7D- continuous	Gastrointestinal: Other changes	FCTOD7 29,367,1991
oral/rat	lowest published toxic dose: 14 gm/kg/7D- continuous	Gastrointestinal: Other changes	FCTOD7 29,367,1991
skin/mouse	lowest published toxic dose: 22553.6 mg/kg/16W- intermittent		TXAPA9 278,148,2014

Reviews

Organization	Standard	Reference
TOXICOLOGY REVIEW		AMIHAB 21,100,1960
TOXICOLOGY REVIEW		ENTOX* -,368,2005
TOXICOLOGY REVIEW		NBREV* 5,1,1981

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit-RUSSIA	short term exposure limit 10 mg/m³, JUN2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code 84458; Number of Industries 7; Total Number of Facilities 333; Number of Occupations 27; Total Number of Employees Exposed 11600; Total Number of Female Employees Exposed 3391
National Occupational Hazard Survey 1974	Hazard Code 84458; Number of Industries 6; Total Number of Facilities 113; Number of Occupations 12; Total Number of Employees Exposed 1747

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health