Butyraldehyde
RTECS #
ES2275000
CAS #
Updated
June 2018
Molecular Weight
72.12
Molecular Formula
C4H8O
Synonyms
Aldehyde butyrique (French)
Aldeide butirrica (Italian)
Butal
Butaldehyde
Butalyde
Butanal
Butanaldehyde
Butyl aldehyde
Butyral
Butyraldehyd (German)
Butyric aldehyde
n-Butanal (Czech)
n-Butyl aldehyde
n-Butyraldehyde
NCI-C56291
Aldeide butirrica (Italian)
Butal
Butaldehyde
Butalyde
Butanal
Butanaldehyde
Butyl aldehyde
Butyral
Butyraldehyd (German)
Butyric aldehyde
n-Butanal (Czech)
n-Butyl aldehyde
n-Butyraldehyde
NCI-C56291
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /rabbit | 20 mg/24H | moderate | 85JCAE -,270,1986 |
skin /rabbit | 410 mg open irritation test | mild | UCDS** 7/20/1965 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
DNA Damage | lymphocyte/mammal (species unspecified) | 100 mmol/L | MUREAV 283,131,1992 |
mutation in mammalian somatic cells | lung/hamster | 3 mmol/L | MUTAEX 4,277,1989 |
sister chromatid exchange | ovary/hamster | 9 mg/L | EMMUEG 10(Suppl 10),1,1987 |
sperm morphology | intraperitoneal/mouse | 30 mg/kg | MUREAV 39,317,1977 |
sperm morphology | oral/mouse | 15 gm/kg/50D | MUREAV 39,317,1977 |
Unscheduled DNA Synthesis | liver/rat | 30 mmol/L | MUREAV 323,121,1994 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Human, lung tumor | Inhibitor Concentration (20 percent kill): 4.6 mmol/L/48H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TXCYAC 334,111,2015 |
In Vitro/Human, lung tumor | Inhibitor Concentration (10 percent kill): 4.3 mmol/L/48H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TXCYAC 334,111,2015 |
In Vitro/Human, lung tumor | Inhibitor Concentration (50 percent kill): 4.1 mmol/L/48H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TXCYAC 334,111,2015 |
In Vitro/Human, lung tumor | Inhibitor Concentration Low: 4.1 mmol/L/48H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TXCYAC 334,111,2015 |
In Vitro/Rabbit, ocular | Inhibitor Concentration Low: 5 pph/5M | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 27,1855,2013 |
inhalation/cat | lowest published toxic concentration: 5000 mg/m3 | Gastrointestinal: Changes in structure or function of salivary glands | VCVGK* -,373,1984 |
inhalation/human | lowest published toxic concentration: 13 mg/m3 | Eye: Conjunctiva irritation | VCVGK* -,373,1984 |
inhalation/human | lowest published toxic concentration: 0.075 mg/m3 | Brain and Coverings: Other degenerative changes | VCVGK* -,373,1984 |
inhalation/mammal (species unspecified) | lethal concentration (50 percent kill): 38 gm/m3 | GISAAA 51(5),61,1986 | |
inhalation/mouse | lethal concentration (50 percent kill): 44610 mg/m3/2H | 85GMAT -,30,1982 | |
inhalation/mouse | lethal concentration (50 percent kill): 36000 mg/m3/2H | Eye: Conjunctiva irritation Behavioral: Ataxia Lung, Thorax, or Respiration: Acute pulmonary edema | VCVGK* -,373,1984 |
inhalation/rabbit | lowest published toxic concentration: 200 mg/m3/40M | Lung, Thorax, or Respiration: Dyspnea | VCVGK* -,373,1984 |
inhalation/rat | lethal concentration (50 percent kill): 6400 ppm/4H | Eye: Conjunctiva irritation Behavioral: Ataxia Lung, Thorax, or Respiration: Acute pulmonary edema | VCVGK* -,373,1984 |
inhalation/rat | lowest published toxic concentration: 600 ppm/10M | Lung, Thorax, or Respiration: Respiratory depression | VCVGK* -,373,1984 |
inhalation/rat | lethal concentration (50 percent kill): 60000 ppm/30M | ENTOX* -,367,2005 | |
inhalation/rat | Lowest published lethal concentration: 8000 ppm/4H | NTIS** OTS0516688 | |
intraperitoneal/mouse | lethal dose (50 percent kill): 1140 mg/kg | FCTXAV 17,731,1979 | |
intraperitoneal/rat | lethal dose (50 percent kill): 800 mg/kg | FCTXAV 17,731,1979 | |
oral/rat | lethal dose (50 percent kill): 5890 mg/kg | Eye: Conjunctiva irritation Behavioral: Ataxia Lung, Thorax, or Respiration: Acute pulmonary edema | VCVGK* -,373,1984 |
oral/rat | lethal dose (50 percent kill): 2490 mg/kg | NTIS** OTS0516688 | |
skin/rabbit | lethal dose (50 percent kill): 3560 µL/kg | UCDS** 7/20/1965 | |
subcutaneous/mouse | lethal dose (50 percent kill): 2700 mg/kg | Behavioral: General anesthetic Kidney, Ureter, and Bladder: Hematuria | APTOA6 6,299,1950 |
subcutaneous/rat | lethal dose (50 percent kill): 10 gm/kg | Behavioral: General anesthetic | APTOA6 6,299,1950 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/Dog | lowest published toxic concentration: 3100 ppm/6H/2W- intermittent | Eye: Lacrimation Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands | NTIS** OTS0570659 |
inhalation/Dog | lowest published toxic concentration: 2000 ppm/6H/14W- intermittent | Olfaction: Other olfaction effects | NTIS** OTS0538653 |
inhalation/guinea pig | lowest published toxic concentration: 3100 ppm/6H/2W- intermittent | Eye: Lacrimation Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0570659 |
inhalation/mouse | lowest published toxic concentration: 6400 ppm/6H/2W- intermittent | Eye: Other eye effects Lung, Thorax, or Respiration: Dyspnea Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTIS** OTS0570659 |
inhalation/rabbit | lowest published toxic concentration: 3100 ppm/6H/2W- intermittent | Eye: Lacrimation Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands | NTIS** OTS0570659 |
inhalation/rabbit | lowest published toxic concentration: 50 mg/m3/110D- intermittent | Lung, Thorax, or Respiration: Emphysema Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,373,1994 |
inhalation/rat | lowest published toxic concentration: 0.5 mg/m3/120D- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | VCVGK* -,373,1994 |
inhalation/rat | lowest published toxic concentration: 50 mg/m3/110D- intermittent | Lung, Thorax, or Respiration: Emphysema Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,373,1994 |
inhalation/rat | lowest published toxic concentration: 125 ppm/6H/13W- intermittent | Olfaction: Other olfaction effects | VCVGK* -,373,1994 |
inhalation/rat | lowest published toxic concentration: 3100 ppm/6H/2W- intermittent | Lung, Thorax, or Respiration: Dyspnea Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0570659 |
inhalation/rat | lowest published toxic concentration: 125 ppm/6H/13W- intermittent | Olfaction: Other olfaction effects Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | NTIS** OTS0538653 |
oral/mouse | lowest published toxic dose: 78 gm/kg/90D- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0516688 |
oral/mouse | lowest published toxic dose: 15000 mg/kg/12D- intermittent | Lung, Thorax, or Respiration: Changes in lung weight Gastrointestinal: Ulceration or bleeding from stomach | VCVGK* -,373,1994 |
oral/rat | lowest published toxic dose: 39 gm/kg/90D- intermittent | Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTIS** OTS0516688 |
oral/rat | lowest published toxic dose: 15000 mg/kg/12D- intermittent | Lung, Thorax, or Respiration: Changes in lung weight Gastrointestinal: Ulceration or bleeding from stomach | VCVGK* -,373,1994 |
Reviews
Organization | Standard | Reference |
---|---|---|
TOXICOLOGY REVIEW | EVHPAZ 11,163,1975 | |
TOXICOLOGY REVIEW | ENTOX* -,367,2005 | |
TOXICOLOGY REVIEW | FCTOD7 94,93,2016 | |
TOXICOLOGY REVIEW | TIVIEQ 36,105,2016 |
Standards and Regulations
NIOSH Documentation and Surveillance
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health