Butyraldehyde

RTECS #
ES2275000
CAS #
123-72-8
See: NMAM or OSHA Methods
Updated
June 2018
Molecular Weight
72.12
Molecular Formula
C4H8O
Synonyms
Aldehyde butyrique (French)
Aldeide butirrica (Italian)
Butal
Butaldehyde
Butalyde
Butanal
Butanaldehyde
Butyl aldehyde
Butyral
Butyraldehyd (German)
Butyric aldehyde
n-Butanal (Czech)
n-Butyl aldehyde
n-Butyraldehyde
NCI-C56291

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg/24H moderate85JCAE -,270,1986
skin /rabbit 410 mg open irritation test mildUCDS** 7/20/1965

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagelymphocyte/mammal (species unspecified)100 mmol/LMUREAV 283,131,1992
mutation in mammalian somatic cellslung/hamster3 mmol/LMUTAEX 4,277,1989
sister chromatid exchangeovary/hamster9 mg/LEMMUEG 10(Suppl 10),1,1987
sperm morphologyintraperitoneal/mouse30 mg/kgMUREAV 39,317,1977
sperm morphologyoral/mouse15 gm/kg/50DMUREAV 39,317,1977
Unscheduled DNA Synthesisliver/rat30 mmol/LMUREAV 323,121,1994

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, lung tumor Inhibitor Concentration (20 percent kill): 4.6 mmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 334,111,2015
In Vitro/Human, lung tumor Inhibitor Concentration (10 percent kill): 4.3 mmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 334,111,2015
In Vitro/Human, lung tumor Inhibitor Concentration (50 percent kill): 4.1 mmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 334,111,2015
In Vitro/Human, lung tumor Inhibitor Concentration Low: 4.1 mmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 334,111,2015
In Vitro/Rabbit, ocular Inhibitor Concentration Low: 5 pph/5MIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1855,2013
inhalation/cat lowest published toxic concentration: 5000 mg/m3Gastrointestinal: Changes in structure or function of salivary glandsVCVGK* -,373,1984
inhalation/human lowest published toxic concentration: 13 mg/m3Eye: Conjunctiva irritationVCVGK* -,373,1984
inhalation/human lowest published toxic concentration: 0.075 mg/m3Brain and Coverings: Other degenerative changesVCVGK* -,373,1984
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 38 gm/m3GISAAA 51(5),61,1986
inhalation/mouse lethal concentration (50 percent kill): 44610 mg/m3/2H85GMAT -,30,1982
inhalation/mouse lethal concentration (50 percent kill): 36000 mg/m3/2HEye: Conjunctiva irritation

Behavioral: Ataxia

Lung, Thorax, or Respiration: Acute pulmonary edema
VCVGK* -,373,1984
inhalation/rabbit lowest published toxic concentration: 200 mg/m3/40MLung, Thorax, or Respiration: DyspneaVCVGK* -,373,1984
inhalation/rat lethal concentration (50 percent kill): 6400 ppm/4HEye: Conjunctiva irritation

Behavioral: Ataxia

Lung, Thorax, or Respiration: Acute pulmonary edema
VCVGK* -,373,1984
inhalation/rat lowest published toxic concentration: 600 ppm/10MLung, Thorax, or Respiration: Respiratory depressionVCVGK* -,373,1984
inhalation/rat lethal concentration (50 percent kill): 60000 ppm/30MENTOX* -,367,2005
inhalation/rat Lowest published lethal concentration: 8000 ppm/4HNTIS** OTS0516688
intraperitoneal/mouse lethal dose (50 percent kill): 1140 mg/kgFCTXAV 17,731,1979
intraperitoneal/rat lethal dose (50 percent kill): 800 mg/kgFCTXAV 17,731,1979
oral/rat lethal dose (50 percent kill): 5890 mg/kgEye: Conjunctiva irritation

Behavioral: Ataxia

Lung, Thorax, or Respiration: Acute pulmonary edema
VCVGK* -,373,1984
oral/rat lethal dose (50 percent kill): 2490 mg/kgNTIS** OTS0516688
skin/rabbit lethal dose (50 percent kill): 3560 µL/kgUCDS** 7/20/1965
subcutaneous/mouse lethal dose (50 percent kill): 2700 mg/kgBehavioral: General anesthetic

Kidney, Ureter, and Bladder: Hematuria
APTOA6 6,299,1950
subcutaneous/rat lethal dose (50 percent kill): 10 gm/kgBehavioral: General anestheticAPTOA6 6,299,1950

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 3100 ppm/6H/2W- intermittentEye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
NTIS** OTS0570659
inhalation/Dog lowest published toxic concentration: 2000 ppm/6H/14W- intermittentOlfaction: Other olfaction effectsNTIS** OTS0538653
inhalation/guinea pig lowest published toxic concentration: 3100 ppm/6H/2W- intermittentEye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0570659
inhalation/mouse lowest published toxic concentration: 6400 ppm/6H/2W- intermittentEye: Other eye effects

Lung, Thorax, or Respiration: Dyspnea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0570659
inhalation/rabbit lowest published toxic concentration: 3100 ppm/6H/2W- intermittentEye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
NTIS** OTS0570659
inhalation/rabbit lowest published toxic concentration: 50 mg/m3/110D- intermittentLung, Thorax, or Respiration: Emphysema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,373,1994
inhalation/rat lowest published toxic concentration: 0.5 mg/m3/120D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
VCVGK* -,373,1994
inhalation/rat lowest published toxic concentration: 50 mg/m3/110D- intermittentLung, Thorax, or Respiration: Emphysema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,373,1994
inhalation/rat lowest published toxic concentration: 125 ppm/6H/13W- intermittentOlfaction: Other olfaction effectsVCVGK* -,373,1994
inhalation/rat lowest published toxic concentration: 3100 ppm/6H/2W- intermittentLung, Thorax, or Respiration: Dyspnea

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0570659
inhalation/rat lowest published toxic concentration: 125 ppm/6H/13W- intermittentOlfaction: Other olfaction effects

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
NTIS** OTS0538653
oral/mouse lowest published toxic dose: 78 gm/kg/90D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0516688
oral/mouse lowest published toxic dose: 15000 mg/kg/12D- intermittentLung, Thorax, or Respiration: Changes in lung weight

Gastrointestinal: Ulceration or bleeding from stomach
VCVGK* -,373,1994
oral/rat lowest published toxic dose: 39 gm/kg/90D- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0516688
oral/rat lowest published toxic dose: 15000 mg/kg/12D- intermittentLung, Thorax, or Respiration: Changes in lung weight

Gastrointestinal: Ulceration or bleeding from stomach
VCVGK* -,373,1994

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWEVHPAZ 11,163,1975
TOXICOLOGY REVIEWENTOX* -,367,2005
TOXICOLOGY REVIEWFCTOD7 94,93,2016
TOXICOLOGY REVIEWTIVIEQ 36,105,2016

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 20 ppm (64 mg/m3);KZW 20 ppm (64 mg/m3), 2007
Occupational Exposure Limit-FINLANDtime-weighted average 25 ppm (74 mg/m3), NOV2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M0281; Number of Industries 2; Total Number of Facilities 38; Number of Occupations 6; Total Number of Employees Exposed 5392; Total Number of Female Employees Exposed 950
National Occupational Hazard Survey 1974Hazard Code M0281; Number of Industries 3; Total Number of Facilities 91; Number of Occupations 9; Total Number of Employees Exposed 1258

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Aldehydes, screening, 2539
NIOSH CURRENT INTELLIGENCE BULLETIN #55, September 1991
Page last reviewed: November 16, 2018