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Registry of Toxic Effects of Chemical Substances (RTECS)

Butyraldehyde

RTECS #

ES2275000

CAS #

123-72-8

Updated

April 2012

Molecular Weight

72.12

Molecular Formula

C4H8O

Synonyms

Aldehyde butyrique (French)
Aldeide butirrica (Italian)
Butal
Butaldehyde
Butalyde
Butanal
Butanaldehyde
Butyl aldehyde
Butyral
Butyraldehyd (German)
Butyric aldehyde
n-Butanal (Czech)
n-Butyl aldehyde
n-Butyraldehyde
NCI-C56291

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg/24H moderate85JCAE -,270,1986
skin /rabbit 410 mg open irritation test mildUCDS** 7/20/1965

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagelymphocyte/mammal (species unspecified)100 mmol/LMUREAV 283,131,1992
mutation in mammalian somatic cellslung/hamster3 mmol/LMUTAEX 4,277,1989
sister chromatid exchangeovary/hamster9 mg/LEMMUEG 10(Suppl 10),1,1987
sperm morphologyintraperitoneal/mouse30 mg/kgMUREAV 39,317,1977
sperm morphologyoral/mouse15 gm/kg/50DMUREAV 39,317,1977
Unscheduled DNA Synthesisliver/rat30 mmol/LMUREAV 323,121,1994

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat lowest published toxic concentration: 5000 mg/m3Gastrointestinal: Changes in structure or function of salivary glandsVCVGK* -,373,1984
inhalation/human lowest published toxic concentration: 13 mg/m3Eye: Conjunctiva irritationVCVGK* -,373,1984
inhalation/human lowest published toxic concentration: 0.075 mg/m3Brain and Coverings: Other degenerative changesVCVGK* -,373,1984
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 38 gm/m3GISAAA 51(5),61,1986
inhalation/mouse lethal concentration (50 percent kill): 44610 mg/m3/2H85GMAT -,30,1982
inhalation/mouse lethal concentration (50 percent kill): 36000 mg/m3/2HEye: Conjunctiva irritation

Behavioral: Ataxia

Lung, Thorax, or Respiration: Acute pulmonary edema		VCVGK* -,373,1984
inhalation/rabbit lowest published toxic concentration: 200 mg/m3/40MLung, Thorax, or Respiration: DyspneaVCVGK* -,373,1984
inhalation/rat lethal concentration (50 percent kill): 6400 ppm/4HEye: Conjunctiva irritation

Behavioral: Ataxia

Lung, Thorax, or Respiration: Acute pulmonary edema		VCVGK* -,373,1984
inhalation/rat lowest published toxic concentration: 600 ppm/10MLung, Thorax, or Respiration: Respiratory depressionVCVGK* -,373,1984
inhalation/rat lethal concentration (50 percent kill): 60000 ppm/30MENTOX* -,367,2005
inhalation/rat Lowest published lethal concentration: 8000 ppm/4HNTIS** OTS0516688
intraperitoneal/mouse lethal dose (50 percent kill): 1140 mg/kgFCTXAV 17,731,1979
intraperitoneal/rat lethal dose (50 percent kill): 800 mg/kgFCTXAV 17,731,1979
oral/rat lethal dose (50 percent kill): 5890 mg/kgEye: Conjunctiva irritation

Behavioral: Ataxia

Lung, Thorax, or Respiration: Acute pulmonary edema		VCVGK* -,373,1984
oral/rat lethal dose (50 percent kill): 2490 mg/kgNTIS** OTS0516688
skin/rabbit lethal dose (50 percent kill): 3560 µL/kgUCDS** 7/20/1965
subcutaneous/mouse lethal dose (50 percent kill): 2700 mg/kgBehavioral: General anesthetic

Kidney, Ureter, and Bladder: Hematuria		APTOA6 6,299,1950
subcutaneous/rat lethal dose (50 percent kill): 10 gm/kgBehavioral: General anestheticAPTOA6 6,299,1950

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 3100 ppm/6H/2W- intermittentEye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands		NTIS** OTS0570659
inhalation/Dog lowest published toxic concentration: 2000 ppm/6H/14W- intermittentOlfaction: Other olfaction effectsNTIS** OTS0538653
inhalation/guinea pig lowest published toxic concentration: 3100 ppm/6H/2W- intermittentEye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** OTS0570659
inhalation/mouse lowest published toxic concentration: 6400 ppm/6H/2W- intermittentEye: Other eye effects

Lung, Thorax, or Respiration: Dyspnea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		NTIS** OTS0570659
inhalation/rabbit lowest published toxic concentration: 3100 ppm/6H/2W- intermittentEye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands		NTIS** OTS0570659
inhalation/rabbit lowest published toxic concentration: 50 mg/m3/110D- intermittentLung, Thorax, or Respiration: Emphysema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes		VCVGK* -,373,1994
inhalation/rat lowest published toxic concentration: 0.5 mg/m3/120D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases		VCVGK* -,373,1994
inhalation/rat lowest published toxic concentration: 50 mg/m3/110D- intermittentLung, Thorax, or Respiration: Emphysema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes		VCVGK* -,373,1994
inhalation/rat lowest published toxic concentration: 125 ppm/6H/13W- intermittentOlfaction: Other olfaction effectsVCVGK* -,373,1994
inhalation/rat lowest published toxic concentration: 3100 ppm/6H/2W- intermittentLung, Thorax, or Respiration: Dyspnea

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** OTS0570659
inhalation/rat lowest published toxic concentration: 125 ppm/6H/13W- intermittentOlfaction: Other olfaction effects

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)		NTIS** OTS0538653
oral/mouse lowest published toxic dose: 78 gm/kg/90D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** OTS0516688
oral/mouse lowest published toxic dose: 15000 mg/kg/12D- intermittentLung, Thorax, or Respiration: Changes in lung weight

Gastrointestinal: Ulceration or bleeding from stomach		VCVGK* -,373,1994
oral/rat lowest published toxic dose: 39 gm/kg/90D- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		NTIS** OTS0516688
oral/rat lowest published toxic dose: 15000 mg/kg/12D- intermittentLung, Thorax, or Respiration: Changes in lung weight

Gastrointestinal: Ulceration or bleeding from stomach		VCVGK* -,373,1994

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWEVHPAZ 11,163,1975
TOXICOLOGY REVIEWENTOX* -,367,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 20 ppm (64 mg/m3);KZW 20 ppm (64 mg/m3), 2007
Occupational Exposure Limit-FINLANDtime-weighted average 25 ppm (74 mg/m3), NOV2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M0281; Number of Industries 2; Total Number of Facilities 38; Number of Occupations 6; Total Number of Employees Exposed 5392; Total Number of Female Employees Exposed 950
National Occupational Hazard Survey 1974Hazard Code M0281; Number of Industries 3; Total Number of Facilities 91; Number of Occupations 9; Total Number of Employees Exposed 1258

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Aldehydes, screening, 2539
NIOSH CURRENT INTELLIGENCE BULLETIN #55, September 1991

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