Butyraldehyde

RTECS #

ES2275000

CAS #

123-72-8
See: NMAM or OSHA Methods

Updated

June 2018

Molecular Weight

72.12

Molecular Formula

C₄H₈O

Synonyms

Aldehyde butyrique (French)
Aldeide butirrica (Italian)
Butal
Butaldehyde
Butalyde
Butanal
Butanaldehyde
Butyl aldehyde
Butyral
Butyraldehyd (German)
Butyric aldehyde
n-Butanal (Czech)
n-Butyl aldehyde
n-Butyraldehyde
NCI-C56291

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	20 mg/24H	moderate	85JCAE -,270,1986
skin /rabbit	410 mg open irritation test	mild	UCDS** 7/20/1965

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
DNA Damage	lymphocyte/mammal (species unspecified)	100 mmol/L	MUREAV 283,131,1992
mutation in mammalian somatic cells	lung/hamster	3 mmol/L	MUTAEX 4,277,1989
sister chromatid exchange	ovary/hamster	9 mg/L	EMMUEG 10(Suppl 10),1,1987
sperm morphology	intraperitoneal/mouse	30 mg/kg	MUREAV 39,317,1977
sperm morphology	oral/mouse	15 gm/kg/50D	MUREAV 39,317,1977
Unscheduled DNA Synthesis	liver/rat	30 mmol/L	MUREAV 323,121,1994

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, lung tumor	Inhibitor Concentration (20 percent kill): 4.6 mmol/L/48H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TXCYAC 334,111,2015
In Vitro/Human, lung tumor	Inhibitor Concentration (10 percent kill): 4.3 mmol/L/48H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TXCYAC 334,111,2015
In Vitro/Human, lung tumor	Inhibitor Concentration (50 percent kill): 4.1 mmol/L/48H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TXCYAC 334,111,2015
In Vitro/Human, lung tumor	Inhibitor Concentration Low: 4.1 mmol/L/48H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TXCYAC 334,111,2015
In Vitro/Rabbit, ocular	Inhibitor Concentration Low: 5 pph/5M	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 27,1855,2013
inhalation/cat	lowest published toxic concentration: 5000 mg/m³	Gastrointestinal: Changes in structure or function of salivary glands	VCVGK* -,373,1984
inhalation/human	lowest published toxic concentration: 13 mg/m³	Eye: Conjunctiva irritation	VCVGK* -,373,1984
inhalation/human	lowest published toxic concentration: 0.075 mg/m³	Brain and Coverings: Other degenerative changes	VCVGK* -,373,1984
inhalation/mammal (species unspecified)	lethal concentration (50 percent kill): 38 gm/m³		GISAAA 51(5),61,1986
inhalation/mouse	lethal concentration (50 percent kill): 44610 mg/m³/2H		85GMAT -,30,1982
inhalation/mouse	lethal concentration (50 percent kill): 36000 mg/m³/2H	Eye: Conjunctiva irritation Behavioral: Ataxia Lung, Thorax, or Respiration: Acute pulmonary edema	VCVGK* -,373,1984
inhalation/rabbit	lowest published toxic concentration: 200 mg/m³/40M	Lung, Thorax, or Respiration: Dyspnea	VCVGK* -,373,1984
inhalation/rat	lethal concentration (50 percent kill): 6400 ppm/4H	Eye: Conjunctiva irritation Behavioral: Ataxia Lung, Thorax, or Respiration: Acute pulmonary edema	VCVGK* -,373,1984
inhalation/rat	lowest published toxic concentration: 600 ppm/10M	Lung, Thorax, or Respiration: Respiratory depression	VCVGK* -,373,1984
inhalation/rat	lethal concentration (50 percent kill): 60000 ppm/30M		ENTOX* -,367,2005
inhalation/rat	Lowest published lethal concentration: 8000 ppm/4H		NTIS** OTS0516688
intraperitoneal/mouse	lethal dose (50 percent kill): 1140 mg/kg		FCTXAV 17,731,1979
intraperitoneal/rat	lethal dose (50 percent kill): 800 mg/kg		FCTXAV 17,731,1979
oral/rat	lethal dose (50 percent kill): 5890 mg/kg	Eye: Conjunctiva irritation Behavioral: Ataxia Lung, Thorax, or Respiration: Acute pulmonary edema	VCVGK* -,373,1984
oral/rat	lethal dose (50 percent kill): 2490 mg/kg		NTIS** OTS0516688
skin/rabbit	lethal dose (50 percent kill): 3560 µL/kg		UCDS** 7/20/1965
subcutaneous/mouse	lethal dose (50 percent kill): 2700 mg/kg	Behavioral: General anesthetic Kidney, Ureter, and Bladder: Hematuria	APTOA6 6,299,1950
subcutaneous/rat	lethal dose (50 percent kill): 10 gm/kg	Behavioral: General anesthetic	APTOA6 6,299,1950

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/Dog	lowest published toxic concentration: 3100 ppm/6H/2W- intermittent	Eye: Lacrimation Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands	NTIS** OTS0570659
inhalation/Dog	lowest published toxic concentration: 2000 ppm/6H/14W- intermittent	Olfaction: Other olfaction effects	NTIS** OTS0538653
inhalation/guinea pig	lowest published toxic concentration: 3100 ppm/6H/2W- intermittent	Eye: Lacrimation Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0570659
inhalation/mouse	lowest published toxic concentration: 6400 ppm/6H/2W- intermittent	Eye: Other eye effects Lung, Thorax, or Respiration: Dyspnea Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** OTS0570659
inhalation/rabbit	lowest published toxic concentration: 3100 ppm/6H/2W- intermittent	Eye: Lacrimation Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands	NTIS** OTS0570659
inhalation/rabbit	lowest published toxic concentration: 50 mg/m³/110D- intermittent	Lung, Thorax, or Respiration: Emphysema Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,373,1994
inhalation/rat	lowest published toxic concentration: 0.5 mg/m³/120D- intermittent	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases	VCVGK* -,373,1994
inhalation/rat	lowest published toxic concentration: 50 mg/m³/110D- intermittent	Lung, Thorax, or Respiration: Emphysema Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,373,1994
inhalation/rat	lowest published toxic concentration: 125 ppm/6H/13W- intermittent	Olfaction: Other olfaction effects	VCVGK* -,373,1994
inhalation/rat	lowest published toxic concentration: 3100 ppm/6H/2W- intermittent	Lung, Thorax, or Respiration: Dyspnea Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0570659
inhalation/rat	lowest published toxic concentration: 125 ppm/6H/13W- intermittent	Olfaction: Other olfaction effects Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	NTIS** OTS0538653
oral/mouse	lowest published toxic dose: 78 gm/kg/90D- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0516688
oral/mouse	lowest published toxic dose: 15000 mg/kg/12D- intermittent	Lung, Thorax, or Respiration: Changes in lung weight Gastrointestinal: Ulceration or bleeding from stomach	VCVGK* -,373,1994
oral/rat	lowest published toxic dose: 39 gm/kg/90D- intermittent	Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** OTS0516688
oral/rat	lowest published toxic dose: 15000 mg/kg/12D- intermittent	Lung, Thorax, or Respiration: Changes in lung weight Gastrointestinal: Ulceration or bleeding from stomach	VCVGK* -,373,1994

Reviews

Organization	Standard	Reference
TOXICOLOGY REVIEW		EVHPAZ 11,163,1975
TOXICOLOGY REVIEW		ENTOX* -,367,2005
TOXICOLOGY REVIEW		FCTOD7 94,93,2016
TOXICOLOGY REVIEW		TIVIEQ 36,105,2016

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit-AUSTRIA	MAK-TMW 20 ppm (64 mg/m³);KZW 20 ppm (64 mg/m³), 2007
Occupational Exposure Limit-FINLAND	time-weighted average 25 ppm (74 mg/m³), NOV2011
Occupational Exposure Limit-RUSSIA	short term exposure limit 5 mg/m³, Skin, JUN2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code M0281; Number of Industries 2; Total Number of Facilities 38; Number of Occupations 6; Total Number of Employees Exposed 5392; Total Number of Female Employees Exposed 950
National Occupational Hazard Survey 1974	Hazard Code M0281; Number of Industries 3; Total Number of Facilities 91; Number of Occupations 9; Total Number of Employees Exposed 1258

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Aldehydes, screening, 2539
NIOSH CURRENT INTELLIGENCE BULLETIN #55, September 1991

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health