Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Brucine

RTECS #

EH8925000

CAS #

357-57-3

Updated

October 2017

Molecular Weight

394.51

Molecular Formula

C23H26N2O4

Synonyms

(-)-Brucine
10,11-Dimethystrychnine
2,3-Dimethoxystrychnidin-10-one
2,3-Dimethoxy-strychnine
Brucina (Italian)
Brucine alkaloid
Dimethoxy strychnine
RCRA waste number P018
Strychnidin-10-one, 2,3-dimethoxy- (9CI)
Strychnine, 2,3-dimethoxy-

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageother cell types/chicken7.07 µmol/L/40HMUTAEX 31,69,2016

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, colon tumor Inhibitor Concentration (50 percent kill): 6.52 µmol/L/72HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FTRPAE 86,193,2013
In Vitro/Human, colon tumor Inhibitor Concentration (50 percent kill): 15.1 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FCTOD7 58,332,2013
In Vitro/Human, colon tumor Inhibitor Concentration Low: 2 µmol/L/48HIn Vitro Toxicity Studies: Other assaysFCTOD7 58,332,2013
In Vitro/Human, colon tumor Inhibitor Concentration Low: 4 µmol/L/48HIn Vitro Toxicity Studies: Apoptosis in vitroFCTOD7 58,332,2013
In Vitro/Human, HeLa cell Inhibitor Concentration (50 percent kill): 441.35 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FTRPAE 86,193,2013
In Vitro/Human, HeLa cell Inhibitor Concentration (50 percent kill): 62.04 µmol/L/72HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FTRPAE 86,193,2013
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 59.55 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FTRPAE 86,193,2013
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 23.91 µmol/L/72HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FTRPAE 86,193,2013
In Vitro/Human, liver tumor Inhibitor Concentration Low: 20 µmol/L/48HIn Vitro Toxicity Studies: Other assaysTOLED5 222,91,2013
In Vitro/Human, lung tumor Inhibitor Concentration (50 percent kill): 64.1 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FCTOD7 58,332,2013
In Vitro/Human, lung tumor Inhibitor Concentration (50 percent kill): 83.36 µmol/L/72HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FTRPAE 86,193,2013
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 59.6 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): 114.08 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FTRPAE 86,193,2013
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): 45.63 µmol/L/72HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FTRPAE 86,193,2013
In Vitro/jkhInhibitor Concentration (50 percent kill): 14.75 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FTRPAE 86,193,2013
In Vitro/jkhInhibitor Concentration (50 percent kill): 3.12 µmol/L/72HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FTRPAE 86,193,2013
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 163 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 27,1357,2013
In Vitro/paaInhibitor Concentration Low: 189 µmol/L/44HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,1416,2013
intraperitoneal/mouse lowest published toxic dose: 10.3 mg/kgBehavioral: AnalgesiaJOETD7 88,205,2003
intraperitoneal/mouse lethal dose (50 percent kill): 62 mg/kgBehavioral: Convulsions or effect on seizure thresholdJOETD7 35,295,1992
intraperitoneal/rat lethal dose (50 percent kill): 91 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Rigidity (includes catalepsy)

Behavioral: Muscle contraction or spasticity
JPETAB 131,185,1961
intraperitoneal/rat lowest published toxic dose: 15 mg/kgBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationJOETD7 88,205,2003
intraperitoneal/rat lowest published toxic dose: 7 mg/kgBehavioral: AnalgesiaJOETD7 88,205,2003
intravenous/Dog lowest published lethal dose: 8 mg/kgHBAMAK 4,1289,1935
intravenous/guinea pig lowest published lethal dose: 120 mg/kgNTIS** PB214-270
intravenous/mouse lethal dose (50 percent kill): 12 mg/kgBehavioral: Convulsions or effect on seizure thresholdJOETD7 35,295,1992
intravenous/rabbit lowest published lethal dose: 30 mg/kgNTIS** PB214-270
oral/mouse lethal dose (50 percent kill): 150 mg/kgBehavioral: Convulsions or effect on seizure thresholdJOETD7 35,295,1992
skin/mouse lowest published toxic dose: 24 mg/kgBehavioral: AnalgesiaJOETD7 139,181,2012
skin/mouse lowest published toxic dose: 6 mg/kgBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationJOETD7 139,181,2012
skin/mouse lowest published toxic dose: 40 mg/kgBehavioral: Analgesia

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
FTRPAE 86,193,2013
subcutaneous/mouse lethal dose (50 percent kill): 60 mg/kgBehavioral: Convulsions or effect on seizure thresholdAPSXAS 7,329,1970
subcutaneous/pigeon lowest published lethal dose: 58 mg/kgHBAMAK 4,1289,1935

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 300 mg/kg/20D- intermittentBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationJOETD7 88,205,2003

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFTRPAE 115,155,I2

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84459; Number of Industries 2; Total Number of Facilities 18; Number of Occupations 2; Total Number of Employees Exposed 334; Total Number of Female Employees Exposed 119
National Occupational Hazard Survey 1974Hazard Code 84459; Number of Industries 2; Total Number of Facilities 109; Number of Occupations 3; Total Number of Employees Exposed 150

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
TOP