Bromic acid, potassium salt

RTECS #
EF8725000
CAS #
7758-01-2
See: NMAM or OSHA Methods
Updated
June 2018
Molecular Weight
167.01
Molecular Formula
BrO3·K
Synonyms
EEC No. E924
Potassium bromate

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisintraperitoneal/rat251 mg/kgMUREAV 240,281,1990
Cytogenetic Analysisoral/rat3 mmol/kgMUREAV 147,274,1985
Cytogenetic Analysislung/hamster85 mg/LGMCRDC 27,95,1981
Cytogenetic Analysislymphocyte/human400 mg/L/24HMUREAV 626,48,2007
DNA Damageintraperitoneal/mouse320 mg/kg/4D- intermittentFCTOD7 46,1184,2008
DNA Damageovary/hamster20 mmol/L/15MTXCYAC 221,166,2006
DNA Damageoral/rat200 mg/kgMUREAV 630,28,2007
DNA Damageoral/rat3150 mg/kg/9W-continuousTXCYAC 257,46,2009
DNA Damageother cell types/mouse0.5 mmol/L/3HTXCYAC 267,45,2010
DNA Damagekidney/pig7500 µmol/LCRNGDP 16,335,1995
DNA Damageoral/mouse300 mg/kgMUREAV 493,39,2001
DNA Damageleukocyte/mouse7500 µmol/LCRNGDP 16,335,1995
DNA Damageovary/hamster7.195 mmol/L/4HEMMUEG 40,134,2002
DNA Damageovary/hamster2.5 mmol/L/3HFCTOD7 42,209,2004
DNA Damageintraperitoneal/rat80 mg/kgJJCREP 83,45,1992
DNA Damageother cell types/human1.5 mmol/L/1HMUREAV 726,151,2011
DNA Damageintraperitoneal/mouse100 mg/kgTXAPA9 250,147,2011
DNA Damageother cell types/human5 mmol/L/2HMUTAEX 31,567,2016
DNA Damageleukocyte/human5 mmol/L/2HMUTAEX 31,567,2016
DNA Damageother cell types/human800 µmol/L/90MFCTOD7 95,96,2016
DNA Damageother cell types/human20 mmol/L/30MTIVIEQ 29,1503,2015
DNA repairovary/hamster5 mmol/L/3HFCTOD7 42,209,2004
micronucleus testintraperitoneal/mouse320 mg/kg/4D- intermittentFCTOD7 46,1184,2008
micronucleus testother cell types/mouse0.6 mmol/LMUREAV 655,4,2008
micronucleus testother cell types/mouse0.5 mmol/L/3HMUREAV 726,36,2011
micronucleus testother cell types/human0.1 mmol/L/24HMUREAV 678,30,2009
micronucleus testother cell types/human0.187 mmol/L/3HMUREAV 678,30,2009
micronucleus testother cell types/human0.7 mmol/L/2HMUREAV 678,30,2009
micronucleus testother cell types/human1.25 mmol/L/1HMUREAV 678,30,2009
micronucleus testintraperitoneal/rat60 mg/kgMUREAV 269,113,1992
micronucleus testintraperitoneal/mouse25 mg/kgFCTOD7 26,487,1988
micronucleus testoral/mouse200 mg/kg/24H-continuousFCTOD7 26,487,1988
micronucleus testovary/hamster5 mmol/L/3HFCTOD7 42,209,2004
micronucleus testlung/hamster125 mg/LMUREAV 272,223,1992
micronucleus testoral/mouse87.4 gm/kg/78W-continuousEMMUEG 36,283,2000
micronucleus testoral/mouse4.48 gm/kg/8W-continuousEMMUEG 36,283,2000
micronucleus testlymphocyte/human500 mg/L/24HMUREAV 626,48,2007
micronucleus testoral/rat480 mg/kg/4DMUREAV 2013,87,2013
micronucleus testlung/hamster5000 µmol/L/6H (-enzymatic activation step)MUTAEX 26,709,2011
micronucleus testlung/hamster10000 µmol/L/6H (+enzymatic activation step)MUTAEX 26,709,2011
micronucleus testlung/hamster1250 µmol/L/24H (-enzymatic activation step)MUTAEX 26,709,2011
micronucleus testlung/hamster1250 µmol/L/48H (-enzymatic activation step)MUTAEX 26,709,2011
mutation in microorganisms/Salmonella typhimurium5000 µg/plate/3DMUREAV 816,18,2017
mutation in microorganisms/Salmonella typhimurium3333 µg/plate (+enzymatic activation step)EMMUEG 19(Suppl 21),2,1992
mutation in microorganisms/Salmonella typhimurium1 mg/plate (-enzymatic activation step)AMONDS 3,253,1980
other mutation test systemsother cell types/human20 mmol/LMUREAV 614,37,2006
other mutation test systemsfibroblast/human20 mmol/LMUREAV 614,37,2006
sister chromatid exchangelymphocyte/human400 mg/L/48HMUREAV 626,48,2007
sister chromatid exchangeleukocyte/rat20 µmol/LMUREAV 300,241,1993
specific locus testother cell types/mouse100 mg/L/4HMUREAV 537,21,2003
specific locus testother cell types/mouse0.6 mmol/L/4HMUREAV 537,21,2003
specific locus testother cell types/human2.25 mmol/L/1HMUREAV 726,151,2011
specific locus testother cell types/human2000 units/LMUREAV 726,151,2011

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 4200 mg/kg/13W- continuousTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
JJCREP 78,358,1987
oral/rat lowest published toxic dose: 38500 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
GANNA2 73,335,1982
oral/rat toxic dose: 19635 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Endocrine: Thyroid tumors
ESKHA5 (100),93,1982
oral/rat toxic dose: 19250 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
GANNA2 73,335,1982
oral/rat toxic dose: 10500 mg/kg/39W- continuousTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
JJCREP 78,358,1987
oral/rat toxic dose: 9625 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Endocrine: Thyroid tumors
ESKHA5 (100),93,1982
oral/rat toxic dose: 9625 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
EVHPAZ 69,221,1986
oral/rat toxic dose: 5460 mg/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
JJIND8 77,977,1986
oral/rat lowest published toxic dose: 2400 mg/kg/16W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TXCYAC 187,1,2003
oral/rat lowest published toxic dose: 57.6 gm/kg/16W- intermittentTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TXCYAC 187,1,2003

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, fibroblast Inhibitor Concentration Low: 10 mmol/L/2HIn Vitro Toxicity Studies: Other assaysTIVIEQ 29,1319,2015
In Vitro/Human, kidney Inhibitor Concentration Low: 2 mmol/L/1HIn Vitro Toxicity Studies: Other assaysTXCYAC 290,271,2011
In Vitro/Human, liver tumor Inhibitor Concentration Low: 0.75 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1410,2013
In Vitro/Rat, kidney Inhibitor Concentration Low: 200 ppm/48HIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Other assays
TXCYAC 289,151,2011
In Vitro/Rat, kidney Inhibitor Concentration Low: 200 ppm/24HIn Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.

In Vitro Toxicity Studies: Other assays
TXCYAC 289,151,2011
In Vitro/Rat, kidney Inhibitor Concentration Low: 200 ppm/30MIn Vitro Toxicity Studies: Other assaysTXCYAC 289,151,2011
intraperitoneal/mouse lethal dose (50 percent kill): 177 mg/kgMUREAV 223,399,1989
intraperitoneal/rat lowest published toxic dose: 125 mg/kgKidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 201,173,2004
intraperitoneal/rat lethal dose (50 percent kill): 50 mg/kgJACTDZ 13,400,1994
oral/child lowest published toxic dose: 7125 µL/kgBehavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Nausea or vomiting
BMJOAE 1,1363,1951
oral/hamster lethal dose (50 percent kill): 388 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Hypermotility, diarrhea
EVHPAZ 87,309,1990
oral/human lowest published toxic dose: 714 mg/kgEar: Change in acuity

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
NPRNAY 37,278,1984
oral/mouse lethal dose (50 percent kill): 289 mg/kgMUREAV 223,399,1989
oral/rat lethal dose (50 percent kill): 157 mg/kgOlfaction: Other olfaction effects

Gastrointestinal: Hypermotility, diarrhea
ESKGA2 37,258,1991
subcutaneous/mouse lowest published toxic dose: 80 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 204,9,2005
unreported route/human lowest published lethal dose: 154 mg/kgGastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Renal function tests depressed
FCTOD7 47,2067,2009

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 320 mg/kg/4D- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 46,1184,2008
oral/mouse lowest published toxic dose: 336 mg/kg/14D- continuousBlood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ESKGA2 37,266,1991
oral/mouse lowest published toxic dose: 728 mg/kg/0.5Y- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes
TOXID9 60,152,2001
oral/rat lowest published toxic dose: 28000 mg/kg/100W- continuousKidney, Ureter, and Bladder: Kidney tumorsTXCYAC 221,158,2006
oral/rat lowest published toxic dose: 14000 mg/kg/100W- continuousEndocrine: Thyroid tumorsTXCYAC 221,158,2006
oral/rat lowest published toxic dose: 7000 mg/kg/100W- continuousGastrointestinal: TumorsTXCYAC 221,158,2006
oral/rat lowest published toxic dose: 1400 mg/kg/100W- continuousGastrointestinal: Other changes

Endocrine: Other changes
TXCYAC 221,158,2006
oral/rat lowest published toxic dose: 1.4 mg/kg/2W- continuousKidney, Ureter, and Bladder: Other changesTXCYAC 221,158,2006
oral/rat lowest published toxic dose: 1.4 mg/kg/2W- continuousKidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins
FCTOD7 47,1154,2009
oral/rat lowest published toxic dose: 28 mg/kg/2W- continuousKidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Glycolytic

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
FCTOD7 47,1154,2009
oral/rat lowest published toxic dose: 480 mg/kg/4D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainMUREAV 758,87,2013
oral/rat lowest published toxic dose: 700 mg/kg/7D- intermittentLiver: Other changesTXCYAC 303,133,2013
oral/rat lowest published toxic dose: 700 mg/kg/7D- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in other cell count (unspecified)
TXCYAC 303,133,2013
oral/rat lowest published toxic dose: 32.2 mg/kg/28D- continuousTXAPA9 272,391,2013
oral/rat lowest published toxic dose: 1260 mg/kg/13W- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
EVHPAZ 87,309,1990
subcutaneous/guinea pig lowest published toxic dose: 280 mg/kg/14D- intermittentEar: Changes in vestibular functions

Behavioral: Change in motor activity (specific assay)
TXAPA9 177,103,2001
subcutaneous/guinea pig lowest published toxic dose: 280 mg/kg/14D- intermittentBehavioral: Change in psychophysiological testsTXAPA9 177,103,2001
subcutaneous/guinea pig lowest published toxic dose: 700 mg/kg/14D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)
TXAPA9 177,103,2001

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 40,207,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 73,481,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 40,207,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 73,481,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 73,481,1999
TOXICOLOGY REVIEWMUTAEX 15,431,2000
TOXICOLOGY REVIEWMUREAV 627,10,2007
TOXICOLOGY REVIEWTXCYAC 221,190,2006
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWBCLPT* 96,131,2005
TOXICOLOGY REVIEWMUREAV 636,242,2007
TOXICOLOGY REVIEWMUREAV 659,202,2008
TOXICOLOGY REVIEWMUTAEX 23,271,2008
TOXICOLOGY REVIEWMUREAV 705,165,2010
TOXICOLOGY REVIEWMUTAEX 26,199,2011
TOXICOLOGY REVIEWMUREAV 751,49,2012
TOXICOLOGY REVIEWTXAPA9 254,86,2011
TOXICOLOGY REVIEWMUREAV 769,34,2014
TOXICOLOGY REVIEWMUTAEX 30,5,2015
TOXICOLOGY REVIEWMUREAV 763,181,2015
TOXICOLOGY REVIEWMUREAV 783,19,2015
TOXICOLOGY REVIEWMUREAV 802,1,2016
TOXICOLOGY REVIEWMUTAEX 32,203,2017
TOXICOLOGY REVIEWEMMUEG 55,689,2014

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 3 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81949; Number of Industries 10; Total Number of Facilities 1458; Number of Occupations 24; Total Number of Employees Exposed 26562; Total Number of Female Employees Exposed 11090
National Occupational Hazard Survey 1974Hazard Code 81949; Number of Industries 6; Total Number of Facilities 132; Number of Occupations 9; Total Number of Employees Exposed 3252

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
Page last reviewed: November 16, 2018