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Registry of Toxic Effects of Chemical Substances (RTECS)

Beryllium sulfate (1:1)

RTECS #

DS4800000

CAS #

13510-49-1

Updated

March 2016

Molecular Weight

105.07

Molecular Formula

O4S·Be

Synonyms

Beryllium sulfate (6CI,7CI)
Beryllium sulphate
Sulfuric acid, beryllium salt (1:1)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/rat910 µg/kg/26W-continuousGISAAA 54(8),73,1989
DNA repair/Bacillus subtilis10 mmol/LMUREAV 77,109,1980
morphological transformembryo/rat60 µg/LJJIND8 67,1303,1981
morphological transformembryo/hamster560 µmol/LCNREA8 39,193,1979
morphological transformfibroblast/mouse200 µg/LJJIND8 67,1303,1981
Unscheduled DNA Synthesislymphocyte/mouse5 µmol/LTOLED5 30,89,1986
Unscheduled DNA Synthesisother cell types/mouse3 µmol/LARTODN 56,207,1985

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/monkey lowest published toxic concentration: 38.8 µg/m3/3Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HBTME* -,415,2007
inhalation/rat lowest published toxic dose: 34 µg/m3/56W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HBTME* -,177,2007
inhalation/rat lowest published toxic concentration: 432 µg/m3/26WTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
PEXTAR 2,203,1961
inhalation/rat toxic concentration: 643 µg/m3/39W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
AMIHAB 19,190,1959
inhalation/rat lowest published toxic concentration: 0.035 mg/m3/180D- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HBTME* -,415,2007
intraperitoneal/mouse lowest published toxic dose: 48 mg/kg/8W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
MUREAV 240,217,1990
intratracheal/rat lowest published toxic dose: 17 mg/kg/2W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
AMIHAB 19,190,1959

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat Lowest published lethal concentration: 10 mg/m3EQSSDX 1,1,1975
inhalation/guinea pig lethal concentration (50 percent kill): 47 mg/m3EQSSDX 1,1,1975
inhalation/human lowest published toxic concentration: 0.67 mg/m3Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Body temperature increase
VCVN1* -,95,1988
inhalation/mouse lowest published toxic concentration: 4.05 µg/m3/1HLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
HBTME* -,415,2007
inhalation/mouse Lowest published lethal concentration: 47 mg/m3EQSSDX 1,1,1975
inhalation/rabbit Lowest published lethal concentration: 10 mg/m3EQSSDX 1,1,1975
inhalation/rat Lowest published lethal concentration: 10 mg/m3EQSSDX 1,1,1975
intramuscular/rat lowest published toxic dose: 4.5 mg/kgVascular: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVN1* -,93,1988
intraperitoneal/guinea pig lowest published lethal dose: 100 mg/kgNIHBAZ 181,1,1943
intraperitoneal/mouse lethal dose (50 percent kill): 1200 mg/kgJJIND8 62,911,1979
intraperitoneal/rat lowest published lethal dose: 18 mg/kgXPHPAW 2173,23,1972
intratracheal/Dog lowest published lethal dose: 1000 µg/kgXPHPAW 2173,23,1972
intratracheal/monkey lowest published lethal dose: 1000 µg/kgXPHPAW 2173,23,1972
intratracheal/rat lowest published lethal dose: 10 mg/kgXPHPAW 2173,23,1972
intravenous/Dog lowest published lethal dose: 600 µg/kgXPHPAW 2173,23,1972
intravenous/monkey lowest published lethal dose: 600 µg/kgXPHPAW 2173,23,1972
intravenous/mouse lethal dose (50 percent kill): 0.265 mg/kgVCVN1* -,93,1988
intravenous/rat lethal dose (50 percent kill): 7200 µg/kgXPHPAW 2173,23,1972
oral/mouse lethal dose (50 percent kill): 80 mg/kgVCVN1* -,93,1988
oral/rat lethal dose (50 percent kill): 82 mg/kgVCVN1* -,93,1988
subcutaneous/mouse lethal dose (50 percent kill): 1500 µg/kgXPHPAW 2173,23,1972
subcutaneous/rabbit lethal dose (50 percent kill): 1500 µg/kgXPHPAW 2173,23,1972
subcutaneous/rat lethal dose (50 percent kill): 1500 µg/kgXPHPAW 2173,23,1972

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/cat lowest published toxic concentration: 50 mg(Be)/m3/6H/95D- intermittentBlood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,95,1988
inhalation/Dog lowest published toxic concentration: 50 mg(Be)/m3/6H/95D- intermittentBlood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,95,1988
inhalation/Dog lowest published toxic concentration: 0.04 mg/m3/100D- intermittentBlood: MacrocytosisHBTME* -,415,2007
inhalation/domestic animal lowest published toxic concentration: 50 mg(Be)/m3/6H/95D- intermittentBlood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,95,1988
inhalation/guinea pig lowest published toxic concentration: 50 mg(Be)/m3/6H/95D- intermittentBlood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,95,1988
inhalation/mammal (species unspecified) lowest published toxic concentration: 1.1 mg/m3/6H/8D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVN1* -,95,1988
inhalation/monkey lowest published toxic concentration: 50 mg(Be)/m3/6H/95D- intermittentBlood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,95,1988
inhalation/mouse lowest published toxic concentration: 50 mg(Be)/m3/6H/95D- intermittentBlood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,95,1988
inhalation/pig lowest published toxic concentration: 50 mg(Be)/m3/6H/95D- intermittentBlood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,95,1988
inhalation/rabbit lowest published toxic concentration: 0.43 mg/m3/100D- intermittentBlood: MacrocytosisHBTME* -,415,2007
inhalation/rat lowest published toxic concentration: 2.59 mg/m3/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHBTME* -,415,2007
inhalation/rat lowest published toxic concentration: 0.43 mg/m3/100D- intermittentBlood: MacrocytosisHBTME* -,415,2007
inhalation/rat lowest published toxic concentration: 10 mg/m3/6H/95D- intermittentBlood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,95,1988
oral/rat lowest published toxic dose: 2682 mg/kg/52W- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
CHYCDW 22,335,1988

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.00005 mg(Be)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 23,143,1980
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 58,41,1993
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 58,41,1993
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 100C,116,2012
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 100C,116,2012
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 58,41,1993
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 100C,116,2012
TOXICOLOGY REVIEWCTOXAO 6,497,1973
TOXICOLOGY REVIEWFCTXAV 9,105,1971
TOXICOLOGY REVIEWMUREAV 567,227,2004
TOXICOLOGY REVIEWMUREAV 567,109,2004
TOXICOLOGY REVIEWMUREAV 533,99,2003
TOXICOLOGY REVIEWMUREAV 533,227,2003
TOXICOLOGY REVIEWHBTME* ,415,2007
TOXICOLOGY REVIEWHBTME* ,177,2007

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.002 mg(Be)/m3, Carcinogen, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.002 mg(Be)/m3, Carcinogen, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.001 mg(Be)/m3 (dust), carc, MAY2011
Occupational Exposure Limit-FRANCEVME 0.002 mg(Be)/m3, C2 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARYceiling concentration 0.002 mg(Be)/m3, Carcinogen, SEP2000
Occupational Exposure Limit-INDIAtime-weighted average 0.002 mg(Be)/m3, Carcinogen, JAN1993
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.002 mg(Be)/m3, 2A carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.002 mg(Be)/m3, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.002 mg(Be)/m3, carcinogen, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.001 mg(Be)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.001 mg(Be)/m3, MAC(short term exposure limit) 0.003 mg(Be)/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.001 mg(Be)/m3, short term exposure limit 0.003 mg(Be)/m3, Carcinogen, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.002 mg(Be)/m3, Carcinogen, Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.002 mg(Be)/m3, carc 1, inhal, sen, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.002 mg(Be)/m3, short term exposure limit 0.005 mg(Be)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.002 mg(Be)/m3, carc, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.002 mg(Be)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.002 mg(Be)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.002 mg(Be)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.002 mg(Be)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BERYLLIUM-airCarcinogen not to exceed 0.0005 mg(Be)/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X9972; Number of Industries 3; Total Number of Facilities 30; Number of Occupations 4; Total Number of Employees Exposed 120

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay; In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive/dose response: Cell transform.-BALB/c-3T3
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 10th Report on Carcinogens,2002:Known to be a human carcinogen
On EPA IRIS database
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