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Registry of Toxic Effects of Chemical Substances (RTECS)

Beryllium oxide

RTECS #

DS4025000

CAS #

1304-56-9

Updated

March 2016

Molecular Weight

25.01

Molecular Formula

BeO

Synonyms

Beryllia
Beryllium monoxide
Thermalox

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intratracheal/rat 139 mg/kg (3D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities
GISAAA 51(8),44,1986

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/rabbit lowest published toxic dose: 10 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Musculoskeletal: Tumors
ARPAAQ 88,89,1969
inhalation/rabbit lowest published toxic concentration: 17 mg/m3/5H/48W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Musculoskeletal: Tumors
AMPLAO 51,473,1951
inhalation/rat lowest published toxic concentration: 28 mg/m3/17W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
IMSUAI 40,23,1971
intratracheal/rat lowest published toxic dose: 75 mg/kg/15W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
FKIZA4 71,19,1980
intratracheal/rat toxic dose: 169 mg/kg/2W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
AMIHAB 19,190,1959
intratracheal/rat toxic dose: 79 mg/kg/15W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
SAIGBL 20,230,1978
intravenous/rabbit toxic dose: 625 mg/kg/25W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Musculoskeletal: Tumors
AMSHAR 25,99,1977
intravenous/rabbit toxic dose: 500 mg/kg/48W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Musculoskeletal: Tumors
PEXTAR 2,203,1961
intravenous/rabbit lowest published toxic dose: 500 mg/kg/6W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Musculoskeletal: Tumors
FEPRA7 5,221,1946

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 0.67 mg/m3Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Body temperature increase
VCVN1* -,95,1988
inhalation/mammal (species unspecified) lowest published toxic concentration: 0.2 mg/m3/1HLung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Autoimmune (multiple organ involvement)
VCVN1* -,94,1988
intratracheal/rat lowest published toxic dose: 55.6 mg/kgLung, Thorax, or Respiration: Changes in lung weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TPKVAL 9,187,1967
intratracheal/rat lowest published toxic dose: 55.6 mg/kgCardiac: Cardiomyopathy including infarction

Cardiac: Changes in coronary arteries

Vascular: Other changes
TPKVAL 8,27,1966
intratracheal/rat lowest published toxic dose: 5 mg/kgLung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Bronchogenic carcinoma

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVN1* -,94,1988
oral/mouse lethal dose (50 percent kill): 2062 mg/kgVCVN1* -,93,1988

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 3.6 mg/m3/40D- intermittentBlood: MacrocytosisHBTME* -,415,2007
inhalation/rat lowest published toxic concentration: 2 mg/m3/110D- intermittentLung, Thorax, or Respiration: Fibrosis (interstitial)

Liver: Hepatitis (hepatocellular necrosis), zonal

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,95,1988

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.00005 mg(Be)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 1,17,1972
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 23,143,1980
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 58,41,1993
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 58,41,1993
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 100C,116,2012
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 100C,116,2012
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 58,41,1993
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 100C,116,2012
TOXICOLOGY REVIEWCTOXAO 6,497,1973
TOXICOLOGY REVIEWFCTXAV 9,105,1971
TOXICOLOGY REVIEWMUREAV 533,99,2003
TOXICOLOGY REVIEWHBTME* ,415,2007
TOXICOLOGY REVIEWHTOPA* 1,701,2002

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit-BELGIUMtime-weighted average 0.002 mg(Be)/m3, Carcinogen, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.001 mg(Be)/m3 (dust), carc, MAY2011
Occupational Exposure Limit-FRANCEVME 0.002 mg(Be)/m3, C2 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARYceiling concentration 0.002 mg(Be)/m3, Carcinogen, SEP2000
Occupational Exposure Limit-INDIAtime-weighted average 0.002 mg(Be)/m3, Carcinogen, JAN1993
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.002 mg(Be)/m3, 2A carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.002 mg(Be)/m3, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.002 mg(Be)/m3, carcinogen, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.001 mg(Be)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.001 mg(Be)/m3, MAC(short term exposure limit) 0.003 mg(Be)/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.001 mg(Be)/m3, short term exposure limit 0.003 mg(Be)/m3, Carcinogen, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.002 mg(Be)/m3, Carcinogen, Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.002 mg(Be)/m3, carc 1, inhal, sen, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.002 mg(Be)/m3, short term exposure limit 0.005 mg(Be)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.002 mg(Be)/m3, carc, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.002 mg(Be)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.002 mg(Be)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.002 mg(Be)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.002 mg(Be)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BERYLLIUM-airCarcinogen not to exceed 0.0005 mg(Be)/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X3577; Number of Industries 6; Total Number of Facilities 66; Number of Occupations 9; Total Number of Employees Exposed 4305; Total Number of Female Employees Exposed 849

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
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