Benzophenone
RTECS #
DI9950000
CAS #
Updated
June 2018
Molecular Weight
182.23
Molecular Formula
C13H10O
Synonyms
alpha-Oxodiphenylmethane
alpha-Oxoditane
Benzene, benzoyl-
Benzoylbenzene
Diphenyl ketone
Diphenylmethanone
Ketone, diphenyl
Phenyl ketone
alpha-Oxoditane
Benzene, benzoyl-
Benzoylbenzene
Diphenyl ketone
Diphenylmethanone
Ketone, diphenyl
Phenyl ketone
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| DNA Damage | Ascites tumor/human | 10 mg/L/2H | FCTOD7 42,1323,2004 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rabbit | 600 mg/kg (6-29D pregnant) | Reproductive: Maternal effects: Parturition Reproductive: Effects on fertility: Abortion | NTPTR* TER-99001 |
| oral/rabbit | 1080 mg/kg (6-29D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | NTPTR* TER-99001 |
| oral/rat | 4200 mg/kg (6-19D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | NTPTR* TER-98005 |
| oral/rat | 1400 mg/kg (6-19D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | NTPTR* TER-98005 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, leukemia cells | Inhibitor Concentration (25 percent kill): 514.8 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 27,1920,2013 |
| In Vitro/Human, leukemia cells | Inhibitor Concentration (25 percent kill): 48.6 µmol/L/24H | In Vitro Toxicity Studies: Phototoxicity in vitro | TIVIEQ 27,1920,2013 |
| In Vitro/Human, leukemia cells | Inhibitor Concentration Low: 50 µmol/L/24H | In Vitro Toxicity Studies: Phototoxicity in vitro | TIVIEQ 27,1920,2013 |
| In Vitro/Human, skin | Inhibitor Concentration (20 percent kill): >1000 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 28,13,2014 |
| In Vitro/Human, skin | Inhibitor Concentration (20 percent kill): 31.2 µmol/L/24H | In Vitro Toxicity Studies: Phototoxicity in vitro | TIVIEQ 28,13,2014 |
| In Vitro/Human, skin | Inhibitor Concentration Low: 5 mg/L | In Vitro Toxicity Studies: Phototoxicity in vitro | TOLED5 235,84,2015 |
| In Vitro/Human, skin | Inhibitor Concentration Low: 7.81 µmol/L/24H | In Vitro Toxicity Studies: Phototoxicity in vitro | TIVIEQ 27,103,2013 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 727 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Lung, Thorax, or Respiration: Other changes | EJTXAZ 9,99,1976 |
| oral/mouse | lethal dose (50 percent kill): 2895 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Lung, Thorax, or Respiration: Other changes | EJTXAZ 9,99,1976 |
| oral/rat | lethal dose (50 percent kill): >10 gm/kg | FCTXAV 11,873,1973 | |
| skin/rabbit | lethal dose (50 percent kill): 3535 mg/kg | FCTXAV 11,873,1973 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/guinea pig | lowest published toxic dose: 75 mg/kg/15D- intermittent | Liver: Other changes Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) | BECTA6 50,282,1993 |
| intraperitoneal/rat | lowest published toxic dose: 150 mg/kg/3D- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | TXAPA9 193,66,2003 |
| intraperitoneal/rat | lowest published toxic dose: 900 mg/kg/3D- intermittent | Endocrine: Estrogenic Related to Chronic Data: Changes in uterine weight | TXAPA9 203,9,2005 |
| oral/mouse | lowest published toxic dose: 109 gm/kg/13W- continuous | Liver: Changes in liver weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOXID9 14,221,1994 |
| oral/mouse | lowest published toxic dose: 19600 mg/kg/14W- continuous | Liver: Other changes Liver: Changes in liver weight | NTPTR* NIH-00-3943 |
| oral/mouse | lowest published toxic dose: 38850 mg/kg/37W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* NTP-TR-533 |
| oral/mouse | lowest published toxic dose: 21070 mg/kg/86W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* NTP-TR-533 |
| oral/mouse | lowest published toxic dose: 58800 mg/kg/105W- intermittent | Liver: Tumors | NTPTR* NTP-TR-533 |
| oral/mouse | lowest published toxic dose: 51450 mg/kg/105W- intermittent | Liver: Tumors Blood: Tumors | NTPTR* NTP-TR-533 |
| oral/mouse | lowest published toxic dose: 25725 mg/kg/105W- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Changes in spleen | NTPTR* NTP-TR-533 |
| oral/mouse | lowest published toxic dose: 29400 mg/kg/105W- intermittent | Liver: Other changes Blood: Changes in spleen | NTPTR* NTP-TR-533 |
| oral/mouse | lowest published toxic dose: 110250 mg/kg/105W- intermittent | Eye: Other eye effects | NTPTR* NTP-TR-533 |
| oral/mouse | lowest published toxic dose: 29400 mg/kg/105W- continuous | Liver: Tumors Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Changes in spleen | FCTOD7 45,843,2007 |
| oral/mouse | lowest published toxic dose: 58800 mg/kg/105W- continuous | Liver: Hepatitis (hepatocellular necrosis), zonal | FCTOD7 45,843,2007 |
| oral/mouse | lowest published toxic dose: 117600 mg/kg/105W- continuous | Olfaction: Other olfaction effects Reproductive: Paternal effects: Testes, epididymis, sperm duct | FCTOD7 45,843,2007 |
| oral/mouse | lowest published toxic dose: 25725 mg/kg/105W- continuous | Liver: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Changes in spleen | FCTOD7 45,843,2007 |
| oral/mouse | lowest published toxic dose: 110250 mg/kg/105W- continuous | Olfaction: Other olfaction effects | FCTOD7 45,843,2007 |
| oral/rabbit | lowest published toxic dose: 600 mg/kg/24D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* TER-99001 |
| oral/rabbit | lowest published toxic dose: 400 mg/kg/16D- intermittent | Behavioral: Food intake (animal) | NTPTR* TER-99001 |
| oral/rabbit | lowest published toxic dose: 450 mg/kg/10D- intermittent | Behavioral: Food intake (animal) | NTPTR* TER-99001 |
| oral/rabbit | lowest published toxic dose: 720 mg/kg/16D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* TER-99001 |
| oral/rat | lowest published toxic dose: 1400 mg/kg/14D- intermittent | Behavioral: Sleep Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight | NTPTR* TER-98005 |
| oral/rat | lowest published toxic dose: 1400 mg/kg/14D- intermittent | Skin and Appendages: Other: Hair | NTPTR* TER-98005 |
| oral/rat | lowest published toxic dose: 400 mg/kg/4D- intermittent | Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* TER-98005 |
| oral/rat | lowest published toxic dose: 1000 mg/kg/10D- intermittent | Behavioral: Fluid intake | NTPTR* TER-98005 |
| oral/rat | lowest published toxic dose: 44100 mg/kg/105W- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-533 |
| oral/rat | lowest published toxic dose: 26040 mg/kg/62W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* NTP-TR-533 |
| oral/rat | lowest published toxic dose: 36120 mg/kg/86W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* NTP-TR-533 |
| oral/rat | lowest published toxic dose: 2100 mg/kg/10W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* NTP-TR-533 |
| oral/rat | lowest published toxic dose: 29400 mg/kg/70W- intermittent | Behavioral: Food intake (animal) | NTPTR* NTP-TR-533 |
| oral/rat | lowest published toxic dose: 11025 mg/kg/105W- intermittent | Kidney, Ureter, and Bladder: Bladder tumors Kidney, Ureter, and Bladder: Kidney tumors Blood: Leukemia | NTPTR* NTP-TR-533 |
| oral/rat | lowest published toxic dose: 11025 mg/kg/105W- intermittent | Liver: Other changes | NTPTR* NTP-TR-533 |
| oral/rat | lowest published toxic dose: 11025 mg/kg/105W- intermittent | Kidney, Ureter, and Bladder: Other changes Liver: Change in gall bladder structure or function Liver: Other changes | NTPTR* NTP-TR-533 |
| oral/rat | lowest published toxic dose: 22050 mg/kg/105W- intermittent | Blood: Leukemia | NTPTR* NTP-TR-533 |
| oral/rat | lowest published toxic dose: 47775 mg/kg/105W- intermittent | Blood: Tumors | NTPTR* NTP-TR-533 |
| oral/rat | lowest published toxic dose: 22050 mg/kg/105W- continuous | Kidney, Ureter, and Bladder: Kidney tumors | FCTOD7 45,843,2007 |
| oral/rat | lowest published toxic dose: 11035 mg/kg/105W- continuous | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Leukemia | FCTOD7 45,843,2007 |
| oral/rat | lowest published toxic dose: 44100 mg/kg/105W- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | FCTOD7 45,843,2007 |
| oral/rat | lowest published toxic dose: 22050 mg/kg/105W- continuous | Kidney, Ureter, and Bladder: Kidney tumors Blood: Leukemia | FCTOD7 45,843,2007 |
| oral/rat | lowest published toxic dose: 11035 mg/kg/105W- continuous | Liver: Other changes Kidney, Ureter, and Bladder: Other changes | FCTOD7 45,843,2007 |
| oral/rat | lowest published toxic dose: 14 gm/kg/28D- continuous | Blood: Pigmented or nucleated red blood cells Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood: Changes in erythrocyte (RBC) count | FCTOD7 29,741,1971 |
| oral/rat | lowest published toxic dose: 91 gm/kg/13W- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOXID9 14,221,1994 |
| oral/rat | lowest published toxic dose: 7350 mg/kg/14W- continuous | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | NTPTR* NIH-00-3943 |
| oral/rat | lowest published toxic dose: 1200 mg/kg/3D- intermittent | Endocrine: Estrogenic Reproductive: Maternal effects: Uterus, cervix, vagina Related to Chronic Data: Changes in uterine weight | ARTODN 76,727,2002 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 101,301,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 2B | IMEMDT 101,301,2013 |
| TOXICOLOGY REVIEW | REPTED 25,192,2008 | |
| TOXICOLOGY REVIEW | MUREAV 659,248,2008 | |
| TOXICOLOGY REVIEW | MUREAV 764-765,46,2014 | |
| TOXICOLOGY REVIEW | TOLED5 202,36,2011 |
NIOSH Documentation and Surveillance
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health