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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzoic acid, sodium salt

RTECS #

DH6650000

CAS #

532-32-1

Updated

October 2017

Molecular Weight

144.11

Molecular Formula

C7H5O2·Na

Synonyms

Antimol
Benzoan sodny (Czech)
Benzoate of soda
Benzoate sodium
Benzoesaeure (na-salz) (German)
E 211
Sobenate
Sodium benzoate
Sodium benzoic acid

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 10%/1H open irritation testDERAAC 26,734,1984
skin /human 0.5%/20MJAADDB 26,734,1984

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster1 gm/LATSUDG 4,41,1980
Cytogenetic Analysisfibroblast/hamster2 gm/L/48HMUREAV 48,337,1977
Cytogenetic Analysislymphocyte/human6.25 mg/L/24HFCTOD7 49,763,2011
DNA Damagelymphocyte/human6.25 mg/L/1HFCTOD7 49,763,2011
micronucleus testlymphocyte/human25 mg/L/48HFCTOD7 49,763,2011
sister chromatid exchangelymphocyte/human10 mmol/LMUREAV 241,109,1990
sister chromatid exchangelymphocyte/human6.25 mg/L/24HFCTOD7 49,763,2011
sister chromatid exchangelymphocyte/human8 mmol/L/72HFCTOD7 46,2390,2008

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 3 gm/kg (12-14D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TXAPA9 19,373,1971
intraperitoneal/rat 300 mg/kg (12-14D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathTXAPA9 19,373,1971
oral/rat 44 gm/kg (1-22D pregnant)Reproductive: Specific developmental abnormalities: Homeostasis

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Musculoskeletal system
ESKHA5 (96),47,1978
oral/rat 44 gm/kg (1-22D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)ESKHA5 (96),47,1978

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/mzxInhibitor Concentration Low: 2500 mg/L/72HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FCTOD7 88,40,2016
In Vitro/mzxInhibitor Concentration Low: 1000 mg/L/72HIn Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.FCTOD7 88,40,2016
In Vitro/mzxInhibitor Concentration Low: 1000 mg/L/48HBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationFCTOD7 88,40,2016
In Vitro/Rabbit, ocular Inhibitor Concentration (50 percent kill): 0.03 gm/L/10MIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assayTIVIEQ 3,329,1989
intramuscular/mouse lethal dose (50 percent kill): 2306 mg/kgJPETAB 117,307,1956
intraperitoneal/guinea pig lowest published lethal dose: 1400 mg/kgHBAMAK 4,1313,1935
intravenous/mouse lethal dose (50 percent kill): 1440 mg/kgMECHAN 6,290,1963
intravenous/rat lethal dose (50 percent kill): 1714 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
JAPMA8 31,253,1942
oral/Dog lethal dose (50 percent kill): 2 gm/kgFAONAU 53A,34,1974
oral/mouse lethal dose (50 percent kill): 1600 mg/kgBehavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Dyspnea
GISAAA 51(1),75,1986
oral/rabbit lethal dose (50 percent kill): 2 gm/kgFAONAU 53A,34,1974
oral/rat lethal dose (50 percent kill): 4070 mg/kgJIHTAB 30,63,1948
subcutaneous/frog lowest published lethal dose: 100 mg/kgHBAMAK 4,1313,1935
subcutaneous/guinea pig lowest published lethal dose: 1 gm/kgGISAAA 28(1),45,1963
subcutaneous/rabbit lethal dose (50 percent kill): 2 gm/kgFAONAU 53A,34,1974
subcutaneous/rat lethal dose (50 percent kill): 2 gm/kgGISAAA 28(1),45,1963

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 45 gm/kg/10D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOLED5 69,171,1993
oral/rat lowest published toxic dose: 35200 mg/kg/22D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV141 -,-,2001
oral/rat lowest published toxic dose: 27370 mg/kg/10D- continuousLiver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins
TOLED5 69,171,1993
oral/rat lowest published toxic dose: 84 gm/kg/28D- continuousBehavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIPTAK 144,120,1963
oral/rat lowest published toxic dose: 137 gm/kg/13W- continuousBehavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TRENAF 42,285,1991

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWHUTOX* -,259,1996
TOXICOLOGY REVIEWTXAPA9 243,225,2010
TOXICOLOGY REVIEWFCTOD7 84,133,2015
TOXICOLOGY REVIEWMUREAV 802,1,2016
TOXICOLOGY REVIEWFCTOD7 97,S180,I2

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,297,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X1192; Number of Industries 2; Total Number of Facilities 31; Number of Occupations 2; Total Number of Employees Exposed 430; Total Number of Female Employees Exposed 288
National Occupational Exposure Survey 1983Hazard Code 80214; Number of Industries 143; Total Number of Facilities 20457; Number of Occupations 125; Total Number of Employees Exposed 533161; Total Number of Female Employees Exposed 199915
National Occupational Hazard Survey 1974Hazard Code 80214; Number of Industries 84; Total Number of Facilities 13289; Number of Occupations 69; Total Number of Employees Exposed 92390

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: TRP reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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