Benzoic acid
RTECS #
DG0875000
CAS #
Updated
March 2019
Molecular Weight
122.13
Molecular Formula
C7H6O2
Synonyms
Acide benzoique (French)
Acido benzoico (Italian)
Benzenecarboxylic acid
Benzeneformic acid
Benzenemethanoic acid
Benzoate
Benzoesaeure (German)
Carboxybenzene
Dracylic acid
E 210
HA 1 (acid)
Kyselina benzoova (Czech)
Phenylcarboxylic acid
Phenylformic acid
Retarder BA
Retardex
Salvo liquid
Salvo powder
Tenn-Plas
Acido benzoico (Italian)
Benzenecarboxylic acid
Benzeneformic acid
Benzenemethanoic acid
Benzoate
Benzoesaeure (German)
Carboxybenzene
Dracylic acid
E 210
HA 1 (acid)
Kyselina benzoova (Czech)
Phenylcarboxylic acid
Phenylformic acid
Retarder BA
Retardex
Salvo liquid
Salvo powder
Tenn-Plas
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
skin /human | 22 mg/3D- intermittent | moderate | 85DKA8 -,127,1977 |
skin /human | 0.25%/1H open irritation test | ADVEA4 26,734,1984 | |
skin /human | 0.76%/40M | mild | CODEDG 33,177,1995 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
DNA Damage | lymphocyte/human | 5 mmol/L | FCTOD7 48,1239,2010 |
DNA inhibition | lymphocyte/human | 5 mmol/L | PNASA6 79,1171,1982 |
mutation in microorganisms | /Escherichia coli | 10 mmol/L (-enzymatic activation step) | ZBPIA9 112,226,1959 |
other mutation test systems | oral/Drosophila melanogaster | 50 mmol/L | FCTOD7 46,1034,2008 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/hpc | Inhibitor Concentration Low: 0.25 gm/L/30M | In Vitro Toxicity Studies: Other assays | JOETD7 137,914,2011 |
In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 21 mmol/L/24H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 3,189,1989 |
In Vitro/Human, lymphocyte | Inhibitor Concentration (30 percent kill): >200 mg/L/45H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | TIVIEQ 29,901,2015 |
In Vitro/Human, lymphocyte | Inhibitor Concentration (50 percent kill): >200 mg/L/45H | In Vitro Toxicity Studies: Other assays | TIVIEQ 29,901,2015 |
In Vitro/Human, skin | Inhibitor Concentration (50 percent kill): >2000 µmol/L/48H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TXAPA9 245,281,2010 |
intraperitoneal/guinea pig | lowest published lethal dose: 1400 mg/kg | HBTXAC 5,23,1959 | |
intraperitoneal/mouse | lethal dose (50 percent kill): 1460 mg/kg | CRSBAW 160,1097,1966 | |
intraperitoneal/rat | lethal dose (50 percent kill): 1600 mg/kg | BCFAAI 112,53,1973 | |
intravenous/rat | lethal dose (50 percent kill): 1700 mg/kg | APYPAY 12,173,1961 | |
oral/guinea pig | lowest published lethal dose: 2 gm/kg | MMWOAU 77,13,1930 | |
oral/man | lowest published lethal dose: 500 mg/kg | FCTXAV 17,715,1979 | |
oral/mouse | lethal dose (50 percent kill): 1940 mg/kg | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression Gastrointestinal: Other changes | IYKEDH 15,359,1984 |
oral/rabbit | lowest published lethal dose: 2 gm/kg | HBTXAC 5,23,1959 | |
oral/rat | lethal dose (50 percent kill): 1700 mg/kg | IPSTB3 3,93,1976 | |
skin/human | lowest published toxic dose: 6 mg/kg | Lung, Thorax, or Respiration: Dyspnea Skin: After systemic exposure: Dermatitis, allergic | JOALAS 16,195,1945 |
subcutaneous/frog | lowest published lethal dose: 100 mg/kg | HBTXAC 5,23,1959 | |
subcutaneous/rabbit | lowest published lethal dose: 2 gm/kg | HBTXAC 5,23,1959 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | lowest published toxic concentration: 1200 mg/m3/4W- intermittent | Lung, Thorax, or Respiration: Fibrosis (interstitial) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTIS** OTS0539172 |
Reviews
Organization | Standard | Reference |
---|---|---|
TOXICOLOGY REVIEW | HUTOX* -,259,1996 | |
TOXICOLOGY REVIEW | FCTOD7 47,1287,2009 | |
TOXICOLOGY REVIEW | TXAPA9 243,225,2010 | |
TOXICOLOGY REVIEW | FCTOD7 84,S1,2015 | |
TOXICOLOGY REVIEW | FCTOD7 97,S180,2016 | |
TOXICOLOGY REVIEW | RTOPDW 60,120,2011 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Cancelled | RBREV* -,297,1998 |
Occupational Exposure Limit-RUSSIA | short term exposure limit 5 mg/m3, JUN2003 |
NIOSH Documentation and Surveillance
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health