Benzoic acid, benzyl ester

RTECS #

DG4200000

CAS #

120-51-4
See: NMAM or OSHA Methods

Updated

September 2018

Molecular Weight

212.26

Molecular Formula

C₁₄H₁₂O₂

Synonyms

Ascabin
Ascabiol
Benylate
Benzoic acid, phenylmethyl ester
Benzyl alcohol benzoic ester
Benzyl benzenecarboxylate
Benzyl benzoate
Benzyl phenylformate
Benzylester kyseliny benzoove (Czech)
Benzylets
Colebenz
Novoscabin
Peruscabin
Scabanca
Vanzoate
Venzonate

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, lymphocyte	Inhibitor Concentration (30 percent kill): >200 mg/L/45H	In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.	TIVIEQ 29,901,2015
In Vitro/Human, lymphocyte	Inhibitor Concentration (50 percent kill): >200 mg/L/45H	In Vitro Toxicity Studies: Other assays	TIVIEQ 29,901,2015
In Vitro/Mouse, fibroblast	Inhibitor Concentration (50 percent kill): >11.8 mmol/L/48H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 27,1357,2013
In Vitro/paa	Inhibitor Concentration Low: 124 µmol/L/44H	In Vitro Toxicity Studies: Other assays	TIVIEQ 27,1416,2013
inhalation/mouse	lowest published toxic concentration: 2 pph/10M	Brain and Coverings: Other degenerative changes Behavioral: Antianxiety Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum	PYTOEY 23,1734,2016
intraperitoneal/mouse	lethal dose (50 percent kill): >500 mg/kg		14CYAT 2,1897,1963
oral/cat	lethal dose (50 percent kill): 2240 mg/kg	Behavioral: Tremor Behavioral: Muscle weakness Gastrointestinal: Changes in structure or function of salivary glands	JPETAB 84,358,1945
oral/cat	lethal dose (50 percent kill): 2240 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea	HPV141 -,-,2001
oral/Dog	lethal dose (50 percent kill): >22440 mg/kg		HPV141 -,-,2001
oral/guinea pig	lethal dose (50 percent kill): 1 mL/kg		HPV141 -,-,2001
oral/mouse	lethal dose (50 percent kill): 1.4 mL/kg		HPV141 -,-,2001
oral/rabbit	lethal dose (50 percent kill): 1.8 mL/kg		HPV141 -,-,2001
oral/rabbit	lethal dose (50 percent kill): 1680 mg/kg		FCTXAV 11,1015,1973
oral/rabbit	lethal dose (50 percent kill): 1680 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea	HPV141 -,-,2001
oral/rat	lethal dose (50 percent kill): 2800 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea	HPV141 -,-,2001
oral/rat	lethal dose (50 percent kill): >1 gm/kg		ENTOX* -,264,2005
oral/rat	lethal dose (50 percent kill): 1.7 mL/kg		HPV141 -,-,2001
skin/rabbit	lethal dose (50 percent kill): 4 gm/kg		FCTXAV 11,1015,1973
skin/rat	lethal dose (50 percent kill): 4 mL/kg		HPV141 -,-,2001

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
skin/rabbit	lowest published toxic dose: 180 mL/kg/13W- intermittent	Behavioral: Muscle weakness Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	JPETAB 93,26,1948
skin/rabbit	lowest published toxic dose: 180 mL/kg/90D- intermittent	Brain and Coverings: Encephalitis Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field Related to Chronic Data: Changes in testicular weight	HPV141 -,-,2001
skin/rat	lowest published toxic dose: 60000 mg/kg/30D- intermittent	Behavioral: Tremor Skin: After systemic exposure: Dermatitis, other	HPV141 -,-,2001

Reviews

Organization	Standard	Reference
TOXICOLOGY REVIEW		ENTOX* -,264,2005

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Supported	RBREV* -,297,1998
Occupational Exposure Limit-RUSSIA	short term exposure limit 5 mg/m³, JUN2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code 11590; Number of Industries 28; Total Number of Facilities 5972; Number of Occupations 50; Total Number of Employees Exposed 83538; Total Number of Female Employees Exposed 44948
National Occupational Hazard Survey 1974	Hazard Code 11590; Number of Industries 7; Total Number of Facilities 264; Number of Occupations 38; Total Number of Employees Exposed 11292

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health