Benzoic acid, benzyl ester

RTECS #
DG4200000
CAS #
120-51-4
See: NMAM or OSHA Methods
Updated
December 2017
Molecular Weight
212.26
Molecular Formula
C14H12O2
Synonyms
Ascabin
Ascabiol
Benylate
Benzoic acid, phenylmethyl ester
Benzyl alcohol benzoic ester
Benzyl benzenecarboxylate
Benzyl benzoate
Benzyl phenylformate
Benzylester kyseliny benzoove (Czech)
Benzylets
Colebenz
Novoscabin
Peruscabin
Scabanca
Vanzoate
Venzonate

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, lymphocyte Inhibitor Concentration (30 percent kill): >200 mg/L/45HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TIVIEQ 29,901,2015
In Vitro/Human, lymphocyte Inhibitor Concentration (50 percent kill): >200 mg/L/45HIn Vitro Toxicity Studies: Other assaysTIVIEQ 29,901,2015
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): >11.8 mmol/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 27,1357,2013
In Vitro/paaInhibitor Concentration Low: 124 µmol/L/44HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,1416,2013
intraperitoneal/mouse lethal dose (50 percent kill): >500 mg/kg14CYAT 2,1897,1963
oral/cat lethal dose (50 percent kill): 2240 mg/kgBehavioral: Tremor

Behavioral: Muscle weakness

Gastrointestinal: Changes in structure or function of salivary glands
JPETAB 84,358,1945
oral/cat lethal dose (50 percent kill): 2240 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
HPV141 -,-,2001
oral/Dog lethal dose (50 percent kill): >22440 mg/kgHPV141 -,-,2001
oral/guinea pig lethal dose (50 percent kill): 1 mL/kgHPV141 -,-,2001
oral/mouse lethal dose (50 percent kill): 1.4 mL/kgHPV141 -,-,2001
oral/rabbit lethal dose (50 percent kill): 1.8 mL/kgHPV141 -,-,2001
oral/rabbit lethal dose (50 percent kill): 1680 mg/kgFCTXAV 11,1015,1973
oral/rabbit lethal dose (50 percent kill): 1680 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
HPV141 -,-,2001
oral/rat lethal dose (50 percent kill): 2800 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
HPV141 -,-,2001
oral/rat lethal dose (50 percent kill): >1 gm/kgENTOX* -,264,2005
oral/rat lethal dose (50 percent kill): 1.7 mL/kgHPV141 -,-,2001
skin/rabbit lethal dose (50 percent kill): 4 gm/kgFCTXAV 11,1015,1973
skin/rat lethal dose (50 percent kill): 4 mL/kgHPV141 -,-,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
skin/rabbit lowest published toxic dose: 180 mL/kg/13W- intermittentBehavioral: Muscle weakness

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JPETAB 93,26,1948
skin/rabbit lowest published toxic dose: 180 mL/kg/90D- intermittentBrain and Coverings: Encephalitis

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Related to Chronic Data: Changes in testicular weight
HPV141 -,-,2001
skin/rat lowest published toxic dose: 60000 mg/kg/30D- intermittentBehavioral: Tremor

Skin: After systemic exposure: Dermatitis, other
HPV141 -,-,2001

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWENTOX* -,264,2005

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,297,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 11590; Number of Industries 28; Total Number of Facilities 5972; Number of Occupations 50; Total Number of Employees Exposed 83538; Total Number of Female Employees Exposed 44948
National Occupational Hazard Survey 1974Hazard Code 11590; Number of Industries 7; Total Number of Facilities 264; Number of Occupations 38; Total Number of Employees Exposed 11292

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Page last reviewed: November 16, 2018