Benzofuran

RTECS #
DF6423800
CAS #
271-89-6
See: NMAM or OSHA Methods
Updated
December 2018
Molecular Weight
118.14
Molecular Formula
C8H6O
Synonyms
1-Oxindene
2,3-Benzofuran
Benzo(b)furan
Benzofuran (IUPAC)
Benzofurfuran
Coumarone
Cumarone
NCI-C56166

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagekidney/rat0.125 mmol/L/20HTXCYAC 204,187,2004
DNA Damagekidney/human0.125 mmol/L/20HTXCYAC 204,187,2004
DNA Damageoral/rat500 mg/kgTXCYAC 204,187,2004
micronucleus testkidney/rat0.125 mmol/L/48HTXCYAC 204,187,2004
micronucleus testkidney/human0.125 mmol/L/48HTXCYAC 204,187,2004
micronucleus testoral/rat500 mg/kgTXCYAC 204,187,2004
mutation in mammalian somatic cellslymphocyte/mouse100 mg/LEMMUEG 11,91,1988
other mutation test systemsoral/mouse100 mg/kgMUREAV 343,157,1995
sister chromatid exchangeovary/hamster199 mg/LNTPTR* NTP-TR-370,1989
specific locus testother cell types/mouse1270 µmol/LMUREAV 608,29,2006
specific locus testother cell types/mouse236.3 mg/L/3H (-enzymatic activation step)MUTAEX 25,539,2010

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 30900 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors
NTPTR* NTP-TR-370,1989
oral/mouse lowest published toxic dose: 30900 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors
NTIS** PB90-231127/AS
oral/mouse lowest published toxic dose: 61800 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors
NTIS** PB90-231127/AS
oral/rat lowest published toxic dose: 30900 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** PB90-231127/AS
oral/rat lowest published toxic dose: 61800 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTPTR* NTP-TR-370,1989

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 500 mg/kgEJMCA5 12,383,1977

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 32500 mg/kg/13W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-370,1989
oral/mouse lowest published toxic dose: 437 mg/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-370,1989
oral/rat lowest published toxic dose: 7 gm/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-370,1989
oral/rat lowest published toxic dose: 16250 mg/kg/13W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
NTPTR* NTP-TR-370,1989

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 63,431,1995
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 63,431,1995
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 63,431,1995
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 672,10,2009
TOXICOLOGY REVIEWMUREAV 672,17,2009
TOXICOLOGY REVIEWMUREAV 705,184,2010
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWMUREAV 802,1,2016
TOXICOLOGY REVIEWRTOPDW 55,205,2009

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Hazard Survey 1974Hazard Code M3271; Number of Industries 2; Total Number of Facilities 40; Number of Occupations 2; Total Number of Employees Exposed 111

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110666/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse
NCI Carcinogenesis Studies (gavage);equivocal evidence:rat
NTP Carcinogenesis Studies (gavage);some evidence:rat NTPTR* NTP-TR-370,1989
Page last reviewed: November 16, 2018