Anisole

RTECS #
BZ8050000
CAS #
100-66-3
See: NMAM or OSHA Methods
Updated
February 2006
Molecular Weight
108.15
Molecular Formula
C7H8O
Synonyms
Benzene, methoxy
Ether, methyl phenyl
Methoxybenzene
Methyl phenyl ether
Phenyl methyl ether

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg/24H moderateFCTXAV 17,243,1979

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionlymphocyte/human25 µmol/LRCOCB8 54,133,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 200 mg/m3Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVGK* -,289,1994
inhalation/mouse lowest published toxic concentration: 1880 mg/m3Behavioral: General anestheticVCVGK* -,289,1994
inhalation/mouse lethal concentration (50 percent kill): 3021 mg/m3/2HGTPZAB 28(6),43,1984
inhalation/mouse lethal concentration (50 percent kill): 3020 mg/m3/2HBehavioral: Ataxia

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Liver: Other changes
VCVGK* -,289,1994
inhalation/rat lethal concentration (50 percent kill): 8949 mg/m3/2HBehavioral: Ataxia

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Liver: Other changes
VCVGK* -,289,1994
inhalation/rat lethal concentration (50 percent kill): >5000 mg/m3GTPZAB 28(6),43,1984
intraperitoneal/rat lowest published lethal dose: 500 mg/kgJAFCAU 17,497,1969
oral/guinea pig lethal dose (50 percent kill): 2500 mg/kgVCVGK* -,289,1994
oral/mouse lethal dose (50 percent kill): 2800 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
JPETAB 88,400,1946
oral/mouse lethal dose (50 percent kill): 2900 mg/kgVCVGK* -,289,1994
oral/rat lethal dose (50 percent kill): 3700 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Changes in structure or function of salivary glands

Kidney, Ureter, and Bladder: Hematuria
TXAPA9 6,378,1964
oral/rat lethal dose (50 percent kill): 5290 mg/kgVCVGK* -,289,1994

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 200 mg/m3/122D- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,289,1994
oral/rabbit lowest published toxic dose: 118.3 mg/kg/26W- intermittentEndocrine: Other changesVCVGK* -,290,1994
oral/rabbit lowest published toxic dose: 1500 mg/kg/15D- intermittentLiver: Liver function tests impaired

Blood: Changes in other cell count (unspecified)
VCVGK* -,289,1994
oral/rat lowest published toxic dose: 31740 mg/kg/30D- intermittentLiver: Changes in liver weightVCVGK* -,289,1994

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X1533; Number of Industries 1; Total Number of Facilities 4; Number of Occupations 2; Total Number of Employees Exposed 469

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
Page last reviewed: November 16, 2018