Ammonium, alkyldimethylbenzyl-, chloride

RTECS #

BO3150000

CAS #

8001-54-5; 8011-91-4; 8036-90-6; 8039-63-2; 8045-21-4; 12741-06-9; 39434-18-9; 59890-14-1; 75635-12-0
See: NMAM or OSHA Methods

Updated

September 2018

Molecular Weight

N/R

Molecular Formula

N/R

Synonyms

Alkyl dimethylbenzyl ammonium chloride
Alkyldimethyl(phenylmethyl)quaternary ammonium chlorides
Ammonyx
Arquad dmmcb-75
Barquat MB-50
Bayclean
Benirol
Benzalkonium A
Benzalkonium chloride
Benzalkonium salt
Bionol
Bio-quat 50-24
Bio-quat 50-25
Bio-quat 50-30
Bio-quat 50-40
Bio-quat 50-42
Bio-quat 50-60
Bio-quat 50-65
Bio-quat 80-24
Bio-quat 80-28
Bio-quat 80-40
Bio-quat 80-42
BTC
BTC 100
BTC 2565
BTC 50
BTC 50 USP
BTC 65
BTC 65 USP
BTC 824
BTC 8248
BTC 8249
BTC E-8358
Cequartyl
Culversan LC 80
Dimanin A
Dodigen 226
Drapolene
Drapolex
Enuclen
Gardiquart SV480
Gardiquat 1450
Genamin KDS
Germicin
Germitol
Intexan LB-50
Kemamine BAC
Marinol
Mefarol
Neo Germ-I-tol
Onyx BTC (Onyx oil & chem Co)
Osvan
Paralkan
Pheneene germicidal solution and tincture
Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
Quaternium-1
Romergal CB
Triton K-60
Vikrol RQ
Zephiral
Zephiran chloride

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /human	50 µg	severe	AJOPAA 27,1118,1944
eye /monkey	2 mg/24H	severe	TXAPA9 6,701,1964
eye /rabbit	100 µg		AROPAW 34,99,1945
eye /rabbit	1 mg/24H	severe	TXAPA9 6,701,1964
eye /rabbit	10 mg	mild	TXAPA9 55,501,1980
skin /human	1%/48H	moderate	ADVEA4 95,711,1990
skin /human	3%/24H	mild	ADVEA4 68,192,1988
skin /human	6%/2W		BJDEAZ 148,171,2003
skin /human	150 µg/3D- intermittent	mild	85DKA8 -,127,1977
skin /rabbit	50 mg/24H	moderate	33NFA8 -,2,1975
skin /woman	0.1%	moderate	CODEDG 57,386,2007

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
DNA Damage	liver/rat	1 mg/L/60M	MUTAEX 22,363,2007
DNA Damage	other cell types/human	0.001 pph/15M	MUREAV 772,1,2015
DNA repair	/Bacillus subtilis	50 µg/L	MUREAV 193,21,1988
micronucleus test	lymphocyte/human	1 mg/L/60M	MUTAEX 22,363,2007
sister chromatid exchange	embryo/hamster	1 mg/L	SHIGAZ 74,1365,1987

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
intravaginal/rat	50 mg/kg (1D pregnant)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	JJATDK 5,398,1985
intravaginal/rat	100 mg/kg (1D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetal death	JJATDK 5,398,1985
intravaginal/rat	200 mg/kg (1D pregnant)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)	JJATDK 5,398,1985

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/cda	Inhibitor Concentration Low: 5 pph/4H	In Vitro Toxicity Studies: Other assays	TIVIEQ 29,1283,2015
In Vitro/cda	Inhibitor Concentration (50 percent kill): 4.3 gm/L/60M	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	RTOPDW 66,177,2013
In Vitro/cda	Inhibitor Concentration (50 percent kill): 6.1 gm/L/60M	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	RTOPDW 66,177,2013
In Vitro/Hamster, lung fibroblast	Inhibitor Concentration Low: 20 mmol/L/2H	In Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay	TIVIEQ 27,864,2013
In Vitro/Human, leukemia cells	Inhibitor Concentration (5 percent kill): 5.00 mg/L/30M	In Vitro Toxicity Studies: Cell counting	TIVIEQ 27,857,2013
In Vitro/Human, leukemia cells	Inhibitor Concentration (25 percent kill): 3.0 mg/L/24H	In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.	TIVIEQ 26,1150,2012
In Vitro/Human, liver tumor	Inhibitor Concentration (50 percent kill): 0.003 mmol/L/24H	In Vitro Toxicity Studies: Cell protein synthesis	TIVIEQ 3,189,1989
In Vitro/Human, lymphocyte	Inhibitor Concentration (30 percent kill): 1 mg/L/45H	In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.	TIVIEQ 29,901,2015
In Vitro/Human, lymphocyte	Inhibitor Concentration (50 percent kill): 0.1 mg/L/45H	In Vitro Toxicity Studies: Other assays	TIVIEQ 29,901,2015
In Vitro/Human, monocyte	Inhibitor Concentration (20 percent kill): 0.43 mg/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TOLED5 199,51,2010
In Vitro/Human, monocyte	Inhibitor Concentration (20 percent kill): 0.43 mg/L/2H	In Vitro Toxicity Studies: Other assays	TOLED5 199,51,2010
In Vitro/Human, oral mucosa	Inhibitor Concentration Low: 1 mg/L/5M	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	FCTOD7 74,139,2014
In Vitro/Human, skin	Inhibitor Concentration Low: 0.2 pph/6H	In Vitro Toxicity Studies: Other assays	TIVIEQ 27,2213,2013
In Vitro/Human, skin	Inhibitor Concentration Low: 6 mg/well/60M	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 27,1476,2013
In Vitro/jda	Inhibitor Concentration (50 percent kill): 15 mg/L/1H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TOLED5 212,198,2012
In Vitro/jda	Inhibitor Concentration (50 percent kill): 1.7 gm/L/60M	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	RTOPDW 66,177,2013
In Vitro/jda	Inhibitor Concentration (50 percent kill): 1.6 gm/L/60M	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	RTOPDW 66,177,2013
In Vitro/jda	Inhibitor Concentration Low: 0.01 pph/2M	In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.	TIVIEQ 25,1906,2011
In Vitro/jte	Inhibitor Concentration Low: 0.0008 gm/L/24H	In Vitro Toxicity Studies: Other assays Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TXCYAC 279,130,2011
In Vitro/jte	Inhibitor Concentration Low: 0.0125 gm/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Other assays Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TXCYAC 279,130,2011
In Vitro/jzx	Inhibitor Concentration (50 percent kill): 0.0031 pph/60M	In Vitro Toxicity Studies: Other assays	TIVIEQ 26,150,2012
In Vitro/Rabbit, ocular	Inhibitor Concentration (50 percent kill): 0.0015 gm/L/10M	In Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay	TIVIEQ 3,329,1989
In Vitro/Rabbit, ocular	Inhibitor Concentration (50 percent kill): 4.5 gm/L/60M	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	RTOPDW 66,177,2013
In Vitro/Rabbit, ocular	Inhibitor Concentration (50 percent kill): 4.1 gm/L/60M	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	RTOPDW 66,177,2013
In Vitro/Rabbit, ocular	Inhibitor Concentration Low: 5 pph/5M	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 29,1283,2015
intraarterial/rat	lowest published lethal dose: 15 mg/kg	Lung, Thorax, or Respiration: Respiratory depression	TOLED5 148,113,2004
intraperitoneal/rat	lethal dose (50 percent kill): 14500 µg/kg	Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Ulceration or bleeding from small intestine	KSRNAM 4,219,1970
intravaginal/pig	lowest published toxic dose: 0.012 gm/kg	Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TOPADD 33,465,2005
intravenous/rat	lethal dose (50 percent kill): 13900 µg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea	KSRNAM 4,219,1970
intravenous/rat	lowest published lethal dose: 15 mg/kg	Lung, Thorax, or Respiration: Respiratory depression	TOLED5 148,113,2004
oral/rat	lowest published lethal dose: 250 mg/kg	Lung, Thorax, or Respiration: Respiratory depression Gastrointestinal: Hypermotility, diarrhea	TOLED5 148,113,2004
oral/rat	lethal dose (50 percent kill): 240 mg/kg	Behavioral: Somnolence (general depressed activity) Gastrointestinal: Nausea or vomiting	KSRNAM 4,219,1970
oral/woman	lowest published toxic dose: 266 mg/kg	Behavioral: Hallucinations, distorted perceptions Gastrointestinal: Changes in structure or function of esophagus Gastrointestinal: Hypermotility, diarrhea	HUTODJ 7,191,1988
subcutaneous/mouse	lethal dose (50 percent kill): 64 mg/kg	Behavioral: Somnolence (general depressed activity)	KSRNAM 4,219,1970
subcutaneous/rat	lethal dose (50 percent kill): 400 mg/kg	Behavioral: Somnolence (general depressed activity)	KSRNAM 4,219,1970

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
intravaginal/pig	lowest published toxic dose: 0.048 gm/kg/4D- intermittent	Reproductive: Maternal effects: Uterus, cervix, vagina Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TOPADD 33,465,2005
oral/Dog	lowest published toxic dose: 13125 mg/kg/15W- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	JAPMA8 40,263,1951
oral/rat	lowest published toxic dose: 274 gm/kg/2Y- continuous	Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	JAPMA8 40,263,1951
skin/guinea pig	lowest published toxic dose: 300 µg/kg/3D- intermittent	Skin: After systemic exposure: Dermatitis, other	JTOTDO 2,63,1983
unreported route/rat	lowest published toxic dose: 3136 nL/kg/4W- intermittent	Olfaction: Other olfaction effects	LARYA8 110(2 Pt1),312,2000

Reviews

Organization	Standard	Reference
TOXICOLOGY REVIEW		ARTODN 32,245,1974
TOXICOLOGY REVIEW		JACTDZ 8(4),589,1989
TOXICOLOGY REVIEW		JTCTDW 38,347,2000
TOXICOLOGY REVIEW		HUTOX* -,683,1996
TOXICOLOGY REVIEW		DERCL* 27,289,2009
TOXICOLOGY REVIEW		TXAPA9 250,87,2011
TOXICOLOGY REVIEW		FCTOD7 109,1,2017

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Supported	RBREV* -,77,1998
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.1 mg(Sn)/m³, KZG-week 0.2 mg(Sn)/m³, inhal, skin, JAN2011

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code T1554; Number of Industries 125; Total Number of Facilities 18923; Number of Occupations 80; Total Number of Employees Exposed 486761; Total Number of Female Employees Exposed 309834
National Occupational Hazard Survey 1974	Hazard Code T1554; Number of Industries 23; Total Number of Facilities 1244; Number of Occupations 13; Total Number of Employees Exposed 52380

Status in Federal Agencies

Organization	Reference
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health