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Registry of Toxic Effects of Chemical Substances (RTECS)

Ammonium, alkyldimethylbenzyl-, chloride

RTECS #

BO3150000

CAS #

8001-54-5; 8011-91-4; 8036-90-6; 8039-63-2; 8045-21-4; 12741-06-9; 39434-18-9; 59890-14-1; 75635-12-0

Updated

October 2017

Molecular Weight

N/R

Molecular Formula

N/R

Synonyms

Alkyl dimethylbenzyl ammonium chloride
Alkyldimethyl(phenylmethyl)quaternary ammonium chlorides
Ammonyx
Arquad dmmcb-75
Barquat MB-50
Bayclean
Benirol
Benzalkonium A
Benzalkonium chloride
Benzalkonium salt
Bionol
Bio-quat 50-24
Bio-quat 50-25
Bio-quat 50-30
Bio-quat 50-40
Bio-quat 50-42
Bio-quat 50-60
Bio-quat 50-65
Bio-quat 80-24
Bio-quat 80-28
Bio-quat 80-40
Bio-quat 80-42
BTC
BTC 100
BTC 2565
BTC 50
BTC 50 USP
BTC 65
BTC 65 USP
BTC 824
BTC 8248
BTC 8249
BTC E-8358
Cequartyl
Culversan LC 80
Dimanin A
Dodigen 226
Drapolene
Drapolex
Enuclen
Gardiquart SV480
Gardiquat 1450
Genamin KDS
Germicin
Germitol
Intexan LB-50
Kemamine BAC
Marinol
Mefarol
Neo Germ-I-tol
Onyx BTC (Onyx oil & chem Co)
Osvan
Paralkan
Pheneene germicidal solution and tincture
Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
Quaternium-1
Romergal CB
Triton K-60
Vikrol RQ
Zephiral
Zephiran chloride

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /human 50 µg severeAJOPAA 27,1118,1944
eye /monkey 2 mg/24H severeTXAPA9 6,701,1964
eye /rabbit 100 µgAROPAW 34,99,1945
eye /rabbit 1 mg/24H severeTXAPA9 6,701,1964
eye /rabbit 10 mg mildTXAPA9 55,501,1980
skin /human 1%/48H moderateADVEA4 95,711,1990
skin /human 3%/24H mildADVEA4 68,192,1988
skin /human 6%/2WBJDEAZ 148,171,2003
skin /human 150 µg/3D- intermittent mild85DKA8 -,127,1977
skin /rabbit 50 mg/24H moderate33NFA8 -,2,1975
skin /woman 0.1% moderateCODEDG 57,386,2007

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageliver/rat1 mg/L/60MMUTAEX 22,363,2007
DNA Damageother cell types/human0.001 pph/15MMUREAV 772,1,2015
DNA repair/Bacillus subtilis50 µg/LMUREAV 193,21,1988
micronucleus testlymphocyte/human1 mg/L/60MMUTAEX 22,363,2007
sister chromatid exchangeembryo/hamster1 mg/LSHIGAZ 74,1365,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intravaginal/rat 50 mg/kg (1D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
JJATDK 5,398,1985
intravaginal/rat 100 mg/kg (1D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
JJATDK 5,398,1985
intravaginal/rat 200 mg/kg (1D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)JJATDK 5,398,1985

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Hamster, lung fibroblast Inhibitor Concentration Low: 20 mmol/L/2HIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assayTIVIEQ 27,864,2013
In Vitro/Human, leukemia cells Inhibitor Concentration (5 percent kill): 5.00 mg/L/30MIn Vitro Toxicity Studies: Cell countingTIVIEQ 27,857,2013
In Vitro/Human, leukemia cells Inhibitor Concentration (25 percent kill): 3.0 mg/L/24HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TIVIEQ 26,1150,2012
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 0.003 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Human, monocyte Inhibitor Concentration (20 percent kill): 0.43 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 199,51,2010
In Vitro/Human, monocyte Inhibitor Concentration (20 percent kill): 0.43 mg/L/2HIn Vitro Toxicity Studies: Other assaysTOLED5 199,51,2010
In Vitro/Human, oral mucosa Inhibitor Concentration Low: 1 mg/L/5MIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
FCTOD7 74,139,2014
In Vitro/Human, skin Inhibitor Concentration Low: 0.2 pph/6HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,2213,2013
In Vitro/Human, skin Inhibitor Concentration Low: 6 mg/well/60MIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1476,2013
In Vitro/jdaInhibitor Concentration (50 percent kill): 15 mg/L/1HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 212,198,2012
In Vitro/jdaInhibitor Concentration Low: 0.01 pph/2MIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TIVIEQ 25,1906,2011
In Vitro/jteInhibitor Concentration Low: 0.0008 gm/L/24HIn Vitro Toxicity Studies: Other assays

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 279,130,2011
In Vitro/jteInhibitor Concentration Low: 0.0125 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Other assays

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 279,130,2011
In Vitro/jzxInhibitor Concentration (50 percent kill): 0.0031 pph/60MIn Vitro Toxicity Studies: Other assaysTIVIEQ 26,150,2012
In Vitro/Rabbit, ocular Inhibitor Concentration (50 percent kill): 0.0015 gm/L/10MIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assayTIVIEQ 3,329,1989
intraarterial/rat lowest published lethal dose: 15 mg/kgLung, Thorax, or Respiration: Respiratory depressionTOLED5 148,113,2004
intraperitoneal/rat lethal dose (50 percent kill): 14500 µg/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Ulceration or bleeding from small intestine
KSRNAM 4,219,1970
intravaginal/pig lowest published toxic dose: 0.012 gm/kgBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTOPADD 33,465,2005
intravenous/rat lethal dose (50 percent kill): 13900 µg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
KSRNAM 4,219,1970
intravenous/rat lowest published lethal dose: 15 mg/kgLung, Thorax, or Respiration: Respiratory depressionTOLED5 148,113,2004
oral/rat lowest published lethal dose: 250 mg/kgLung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Hypermotility, diarrhea
TOLED5 148,113,2004
oral/rat lethal dose (50 percent kill): 240 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Nausea or vomiting
KSRNAM 4,219,1970
oral/woman lowest published toxic dose: 266 mg/kgBehavioral: Hallucinations, distorted perceptions

Gastrointestinal: Changes in structure or function of esophagus

Gastrointestinal: Hypermotility, diarrhea
HUTODJ 7,191,1988
subcutaneous/mouse lethal dose (50 percent kill): 64 mg/kgBehavioral: Somnolence (general depressed activity)KSRNAM 4,219,1970
subcutaneous/rat lethal dose (50 percent kill): 400 mg/kgBehavioral: Somnolence (general depressed activity)KSRNAM 4,219,1970

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intravaginal/pig lowest published toxic dose: 0.048 gm/kg/4D- intermittentReproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOPADD 33,465,2005
oral/Dog lowest published toxic dose: 13125 mg/kg/15W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JAPMA8 40,263,1951
oral/rat lowest published toxic dose: 274 gm/kg/2Y- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JAPMA8 40,263,1951
skin/guinea pig lowest published toxic dose: 300 µg/kg/3D- intermittentSkin: After systemic exposure: Dermatitis, otherJTOTDO 2,63,1983
unreported route/rat lowest published toxic dose: 3136 nL/kg/4W- intermittentOlfaction: Other olfaction effectsLARYA8 110(2 Pt1),312,2000

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWARTODN 32,245,1974
TOXICOLOGY REVIEWJACTDZ 8(4),589,1989
TOXICOLOGY REVIEWJTCTDW 38,347,2000
TOXICOLOGY REVIEWHUTOX* -,683,1996
TOXICOLOGY REVIEWDERCL* 27,289,2009
TOXICOLOGY REVIEWTXAPA9 250,87,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,77,1998
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(Sn)/m3, KZG-week 0.2 mg(Sn)/m3, inhal, skin, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code T1554; Number of Industries 125; Total Number of Facilities 18923; Number of Occupations 80; Total Number of Employees Exposed 486761; Total Number of Female Employees Exposed 309834
National Occupational Hazard Survey 1974Hazard Code T1554; Number of Industries 23; Total Number of Facilities 1244; Number of Occupations 13; Total Number of Employees Exposed 52380

Status in Federal Agencies

OrganizationReference
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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