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Registry of Toxic Effects of Chemical Substances (RTECS)

Adipic acid, bis(2-ethylhexyl) ester

RTECS #

AU9700000

CAS #

103-23-1; 39393-67-4; 63637-48-9; 70147-21-6

Updated

April 2017

Molecular Weight

370.64

Molecular Formula

C22H42O4

Synonyms

Adipol 2EH
ADO (lubricating oil)
BEHA
Bis(2-ethylhexyl) adipate
Bis-(2-ethylhexyl)ester kyseliny adipove (Czech)
Bisoflex DOA
Crodamol DOA
Di(2-ethylhexyl) adipate
Di(2-ethylhexyl)adipate
Di-2-ethylhexyl adipate
Dioctyl adipate
DOA
Effomoll DOA
Ergoplast ADDO
Flexol A 26
Hatcol 2908
Hexanedioic acid, bis(2-ethylhexyl) ester (9CI)
Hexanedioic acid, dioctyl ester
Kemester 5652
Kodaflex DOA
Lankroflex DOA
Mollan S
Monoplex DOA
Morflex 310
NCI-C54386
Octyl adipate
Plastomoll DOA
PX-238
Reomol DOA
Rucoflex Plasticizer DOA
Sansocizer DOA
Sicol 250
Staflex DOA
Truflex DOA
Uniflex DOA
Vestinol OA
Wickenol 158
Witamol 320

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster400 mg/LEMMUEG 10(Suppl 10),1,1987
Dominant Lethal Testintraperitoneal/mouse1000 mg/kgTXAPA9 32,566,1975
other mutation test systemsoral/mouse2 gm/kgMUREAV 343,157,1995
phage inhibition capacity/Escherichia coli25 µg/wellMUREAV 260,349,1991
Unscheduled DNA Synthesisoral/rat378 µmol/kgCRNGDP 8,1433,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 15 gm/kg (5-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)JPMSAE 62,1596,1973
intraperitoneal/rat 30 gm/kg (5-15D pregnant)Reproductive: Other developmental abnormalitiesJPMSAE 62,1596,1973
oral/rat 18 gm/kg (7-21D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)REPTED 17,163,2003
oral/rat 14.4 gm/kg (7-21D preg/3D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)REPTED 17,163,2003
oral/rat 13.6 gm/kg (7-23D pregnant)Reproductive: Maternal effects: Parturition

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
REPTED 17,163,2003
oral/rat 30.4 gm/kg (7-23D preg/21D after birth)Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 17,163,2003
oral/rat 11.2 gm/kg (7-21D preg/13D after birth)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)REPTED 17,163,2003
oral/rat 26000 mg/kg (18D prior to copulation/0-7D pregnant)Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
JTSCDR 34,SP101,2009
oral/rat 50000 mg/kg (17D prior to copulation/0-7D pregnant)Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
JTSCDR 34,SP101,2009
oral/rat 50000 mg/kg (17D prior to copulation/0-7D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)JTSCDR 34,SP101,2009

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 1038 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTPTR* NTP-TR-212,1981
oral/mouse toxic dose: 2163 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTPTR* NTP-TR-212,1981
oral/mouse toxic dose: 1048 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
EVHPAZ 65,271,1986
oral/mouse lowest published toxic dose: 2163000 mg/kg/103W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB82-185927
oral/mouse lowest published toxic dose: 1038240 mg/kg/103W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB82-185927

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 5000 mg/kgBFUUA* -,153,1997
intraperitoneal/rabbit lethal dose (50 percent kill): 38000 mg/kgEye: Lacrimation

Eye: Conjunctiva irritation
BFUUA* -,153,1997
intraperitoneal/rat lethal dose (50 percent kill): 46000 mg/kgBFUUA* -,153,1997
intraperitoneal/rat lethal dose (50 percent kill): >50 mL/kgJPMSAE 62,1596,1973
intravenous/rabbit lethal dose (50 percent kill): 540 mg/kgBFUUA* -,153,1997
intravenous/rat lethal dose (50 percent kill): 900 mg/kgBFUUA* -,153,1997
oral/guinea pig lethal dose (50 percent kill): 12900 mg/kgBFUUA* -,153,1997
oral/mammal (species unspecified) lethal dose (50 percent kill): 15 gm/kgIPSTB3 3,93,1976
oral/mouse lethal dose (50 percent kill): 15000 mg/kgBFUUA* -,153,1997
oral/rat lethal dose (50 percent kill): 7392 mg/kgBFUUA* -,153,1997
skin/rabbit lethal dose (50 percent kill): 16 mL/kgAMIHBC 4,119,1951
skin/rabbit lethal dose (50 percent kill): 8410 mg/kg/24HBFUUA* -,153,1997

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 168 gm/kg/14D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-212,1981
oral/mouse lowest published toxic dose: 280 gm/kg/13W- continuousLiver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXCYAC 123,217,1997
oral/mouse lowest published toxic dose: 500 mg/kg/5D- continuousLiver: Changes in liver weight

Liver: Liver function tests impaired

Biochemical: Metabolism (intermediary): Lipids including transport
BFUUA* -,153,1997
oral/rat lowest published toxic dose: 500 mg/kg/5D- continuousLiver: Changes in liver weight

Liver: Liver function tests impaired

Biochemical: Metabolism (intermediary): Lipids including transport
BFUUA* -,153,1997
oral/rat lowest published toxic dose: 8.45 gm/kg/14D- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
ATSUDG 12,274,1988
oral/rat lowest published toxic dose: 18000 mg/kg/15D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainREPTED 17,163,2003
oral/rat lowest published toxic dose: 52500 mg/kg/5W- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 21,253,2006
oral/rat lowest published toxic dose: 5600 mg/kg/28D- intermittentKidney, Ureter, and Bladder: Changes in kidney weightARTODN 80,181,2006
oral/rat lowest published toxic dose: 28000 mg/kg/28D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes
ARTODN 80,181,2006
oral/rat lowest published toxic dose: 28000 mg/kg/28D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in adrenal weight
ARTODN 80,181,2006
oral/rat lowest published toxic dose: 8913.52 mg/kg/4W- intermittentKidney, Ureter, and Bladder: Changes in kidney weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
REPTED 22,411,2006
oral/rat lowest published toxic dose: 43963.36 mg/kg/4W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
REPTED 22,411,2006
oral/rat lowest published toxic dose: 56000 mg/kg/4W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTSCDR 34,SP101,2009
oral/rat lowest published toxic dose: 14000 mg/kg/2W- intermittentLiver: Changes in liver weightJTSCDR 34,SP101,2009
oral/rat lowest published toxic dose: 28000 mg/kg/2W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Changes in ovarian weight
JTSCDR 34,SP101,2009
oral/rat lowest published toxic dose: 5600 mg/kg/4W- intermittentKidney, Ureter, and Bladder: Changes in kidney weightJTSCDR 34,SP101,2009
oral/rat lowest published toxic dose: 28000 mg/kg/4W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes

Reproductive: Maternal effects: Ovaries, fallopian tubes
JTSCDR 34,SP101,2009
oral/rat lowest published toxic dose: 25200 mg/kg/3W- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)TOLED5 10,379,1982
oral/rat lowest published toxic dose: 191 gm/kg/13W- continuousLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXCYAC 123,217,1997

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 77,564,2000
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWJTSCDR 34,SP1,2009
TOXICOLOGY REVIEWMUTAEX 23,271,2008
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWTOLED5 202,36,2011
TOXICOLOGY REVIEWMUREAV 802,1,2016

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80276; Number of Industries 15; Total Number of Facilities 524; Number of Occupations 21; Total Number of Employees Exposed 15636; Total Number of Female Employees Exposed 3628
National Occupational Hazard Survey 1974Hazard Code 80276; Number of Industries 19; Total Number of Facilities 534; Number of Occupations 31; Total Number of Employees Exposed 11847

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive/dose response: Rodent dominant lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8917
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);clear evidence:mouse
NCI Carcinogenesis Studies (feed);no evidence:rat
On EPA IRIS database
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