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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetyl chloride, chloro-

RTECS #

AO6475000

CAS #

79-04-9

Updated

September 2013

Molecular Weight

112.94

Molecular Formula

C2H2Cl2O

Synonyms

Chloracetyl chloride
Chlorid kyseliny chloroctove (Czech)
Chloroacetic acid chloride
Chloroacetic chloride
Chloroacetyl chloride
Chloroacetyl chloride (ACGIH)
Chlorure de chloracetyle (French)
Monochloroacetyl chloride

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 0.1 mL severeHPV172 -,-,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 1300 ppm/2H85INA8 5,123(89),1986
inhalation/rat lethal concentration (50 percent kill): 660 ppm/1HHPV172 -,-,2001
intravenous/mouse lethal dose (50 percent kill): 32 mg/kgCSLNX* NX#04538
oral/mouse lethal dose (50 percent kill): 220 mg/kgGISAAA 54(2),90,1989
oral/rat lethal dose (50 percent kill): 208 mg/kg85INA8 5,123(89),1986
oral/rat lowest published lethal dose: 1260 mg/kgHPV172 -,-,2001
oral/rat lethal dose (50 percent kill): 207 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Blood: Hemorrhage
HPV172 -,-,2001
skin/rabbit lowest published lethal dose: 316 mg/kgLung, Thorax, or Respiration: Other changes

Blood: Hemorrhage

Skin: After topical application: Primary irritation
HPV172 -,-,2001
skin/rabbit lowest published lethal dose: 316 mg/kg85INA8 5,123(89),1986
skin/rat lethal dose (50 percent kill): 662 mg/kgSkin: After topical application: CorrosiveGISAAA 54(2),90,1989

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/hamster lowest published toxic concentration: 5 ppm/6H/4W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** OTS0536493
inhalation/mouse lowest published toxic concentration: 5 ppm/6H/4W- intermittentOlfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0536493
inhalation/rat lowest published toxic concentration: 1 ppm/6H/4W- intermittentOlfaction: Other olfaction effects

Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0536493
inhalation/rat lowest published toxic concentration: 0.5 ppm/4W- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes
HPV172 -,-,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.05 ppm;short term exposure limit 0.15 ppm (skin)DTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.05 ppm (0.23 mg/m3), short term exposure limit 0.15 ppm (0.69 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.05 ppm (0.2 mg/m3);KZW 0.1 ppm (0.4 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.05 ppm (0.23 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 0.15 ppm (0.7 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.05 ppm (0.2 mg/m3), MAY2011
Occupational Exposure Limit-FRANCEVME 0.05 ppm (0.2 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.05 ppm (0.2 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.05 ppm (0.2 mg/m3), 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.05 ppm (0.23 mg/m3); short term exposure limit 0.15 ppm (0.69 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.05 ppm (0.2 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.05 ppm (0.23 mg/m3); short term exposure limit 0.15 ppm (0.7 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.3 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 ppm (0.24 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.2 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLOROACETYL CHLORIDE-air10H time-weighted average 0.05 ppmNIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983Hazard Code A1131; Number of Industries 1; Total Number of Facilities 21; Number of Occupations 5; Total Number of Employees Exposed 4354; Total Number of Female Employees Exposed 729
National Occupational Hazard Survey 1974Hazard Code A1131; Number of Industries 1; Total Number of Facilities 33; Number of Occupations 1; Total Number of Employees Exposed 66

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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