o-Acetotoluidide, 2-chloro-6'-ethyl-N-(2-methoxy-1-methylethyl)-

RTECS #

AN3430000

CAS #

51218-45-2; 63150-68-5; 94449-58-8
See: NMAM or OSHA Methods

Updated

March 2018

Molecular Weight

283.83

Molecular Formula

C₁₅H₂₂ClNO₂

Synonyms

2-Aethyl-6-methyl-N-(1-methyl-2-methoxyaethyl)-chloracetanilid (German)
2-Chloro-6'-ethyl-N-(2-methoxy-1-methylethyl)acet-o-toluidide
2-Chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl)acetamide
2-Ethyl-6-methyl-1-N-(2-methoxy-1-methylethyl)chloroacetanilide
2-Etylo-6-metylo-N-(1'-metylo-2'-metoksyetylo)chloroacetanilid (Polish)
Acetamide, 2-chloro-N-(6-ethyl-o-tolyl)-N-(2-methoxy-1-methylethyl)-
alpha-Chlor-6'-aethyl-N-(2-methoxy-1-methylaethyl)-acet-o-toluidin (German)
alpha-Chloro-2'-ethyl-6'-methyl-N-(1-methyl-2-methoxyethyl)-acetanilide
CGA-24705
Codal
Cotoran multi
Dual
Dual 720EC
Dual Triple
Metachlore
Metelilachlor
Metolachlor
Ontrack 8E

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	100 mg	mild	NNGADV 14,103,1989
skin /rabbit	334 mg open irritation test	mild	CIGET* -,-,1977

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	lymphocyte/human	100 µg/L	MUREAV 281,295,1992
gene conversion and mitotic recombination	/Saccharomyes cerevisiae	1 µg/plate	MUREAV 136,233,1984
mutation in microorganisms	/Salmonella typhimurium	10 µg/plate (-enzymatic activation step)	MUREAV 136,233,1984

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	10 gm/kg (6-15D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system	NNGADV 14,103,1989
unreported route/mammal (species unspecified)	76 mg/kg (multigenerations)	Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)	FEREAC 64,11787,1999

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lethal concentration (50 percent kill): >1750 mg/m³/4H		LITRC* TR-78-0310
intraperitoneal/mouse	lethal dose (50 percent kill): 410 mg/kg		NNGADV 14,103,1989
intraperitoneal/rat	lethal dose (50 percent kill): 620 mg/kg		NNGADV 14,103,1989
intraperitoneal/rat	lowest published toxic dose: 738 mg/kg	Biochemical: Metabolism (intermediary): Other	TOXID9 1,54,2001
oral/duck	lethal dose (50 percent kill): >2510 mg/kg		FMCHA2 -,C203,1991
oral/mouse	lethal dose (50 percent kill): 1150 mg/kg		NNGADV 14,103,1989
oral/rat	lethal dose (50 percent kill): 2200 mg/kg		NNGADV 14,103,1989
skin/rabbit	lethal dose (50 percent kill): >10 gm/kg		LITRC* TR-78-0310
skin/rat	lethal dose (50 percent kill): 3170 mg/kg		MSNRD5 18,341,1979
subcutaneous/mouse	lethal dose (50 percent kill): 2400 mg/kg		NNGADV 14,103,1989
subcutaneous/rat	lethal dose (50 percent kill): >9 gm/kg		NNGADV 14,103,1989
unreported route/rat	lethal dose (50 percent kill): 3170 mg/kg		AGKYAU (5),138,1980

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/Dog	lowest published toxic dose: 4550 mg/kg/26W- continuous	Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	NNGADV 14,103,1989
oral/mouse	lowest published toxic dose: 263 gm/kg/2Y- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NNGADV 14,103,1989
oral/rat	lowest published toxic dose: 5460 mg/kg/13W- continuous	Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NNGADV 14,103,1989
oral/rat	lowest published toxic dose: 131 gm/kg/2Y- continuous	Liver: Other changes Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NNGADV 14,103,1989
oral/rat	lowest published toxic dose: 109200 mg/kg/104W- continuous	Liver: Tumors	HBPTO* 1,814,2001
oral/rat	lowest published toxic dose: 23310 mg/kg/90D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FEREAC 68,15945,2003
unreported route/rat	lowest published toxic dose: 567.7 mg/kg/4D- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	TOXID9 66,321,2002

Reviews

Organization	Standard	Reference
TOXICOLOGY REVIEW		FEREAC 72,44439,2007
TOXICOLOGY REVIEW		FEREAC 73,29456,2008
TOXICOLOGY REVIEW		JTPAE7 19,1,2006
TOXICOLOGY REVIEW		HUTOX* -,551,1996
TOXICOLOGY REVIEW		FEREAC 73,52607,2008
TOXICOLOGY REVIEW		FEREAC 73,53732,2008
TOXICOLOGY REVIEW		FEREAC 74,30487,2009
TOXICOLOGY REVIEW		FEREAC 74,48408,2009
TOXICOLOGY REVIEW		TXCYAC 307,3,2013
TOXICOLOGY REVIEW		TXAPA9 268,157,2013
TOXICOLOGY REVIEW		MUREAV 791-792,19,2017

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989

Status in Federal Agencies

Organization	Reference
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health