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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetanilide, 2-chloro-2',6'-diethyl-N-(methoxymethyl)-

RTECS #

AE1225000

CAS #

15972-60-8

Updated

December 2016

Molecular Weight

269.80

Molecular Formula

C14H20ClNO2

Synonyms

2-Chloro-2',6'-diethyl-N-(methoxymethyl)acetanilide
2-Chloro-N-(2,6-diethyl)phenyl-N-methoxymethylacetamide
Acetamide, 2-chloro-N-(2,6-diethylphenyl)-N-(methoxymethyl)- (9CI)
Alachlor
Alachlore
Alanex
Alanox
Alatox 480
Alochlor
Chloressigsaeure-N-(methoxymethyl)-2,6-diaethylanilid (German)
CP 50144
Lasagrin
Lasso
Lasso micro-tech
LAZO
Metachlor
Methachlor
Pillarzo

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human1 mg/LEMMUEG 19,77,1992
Cytogenetic Analysisintraperitoneal/rat1250 µg/kgMUREAV 116,341,1983
Cytogenetic Analysisoral/mouse72 mg/kg/30D-continuousEMMUEG 19,77,1992
Cytogenetic Analysisovary/hamster10 mg/LMUREAV 188,241,1987
Cytogenetic Analysisoral/rat11.34 gm/kg/90D-continuousTOXID9 72(Supp 1),228,2003
DNA Damageother cell types/chicken11.64 µmol/L/40HMUTAEX 31,69,2016
DNA Damagelymphocyte/human5 mg/LMUREAV 344,41,1995
gene conversion and mitotic recombination/Saccharomyes cerevisiae33 µg/plateMUREAV 136,233,1984
micronucleus testlymphocyte/human40 mg/LMUREAV 441,95,1999
mutation in mammalian somatic cellslymphocyte/mouse5620 µg/LTOSCF2 49,202,1999
mutation in microorganisms/Salmonella typhimurium8 µg/plate (+enzymatic activation step)KHZDAN 29(1),26,1986
mutation in microorganisms/Other microorganisms90 mg/L (-enzymatic activation step)JASIAB 104,571,1985
other mutation test systemsoral/mouse216 mg/kg/90D-continuousEMMUEG 19,77,1992
sister chromatid exchangelymphocyte/human10 µmol/LMUREAV 395,159,1997
sister chromatid exchangelymphocyte/human5 mg/LMUREAV 441,95,1999
sister chromatid exchangeovary/hamster10 µmol/LMUREAV 395,159,1997
specific locus testoral/Drosophila melanogaster1 mmol/LMUREAV 280,291,1992

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 142 gm/kg/78W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
TIHEEC 3,383,1987
oral/rat lowest published toxic dose: 45990 mg/kg/1Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors
TOPADD 33,593,2005
oral/rat lowest published toxic dose: 102 gm/kg/2.2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors

Endocrine: Thyroid tumors
NNGADV 24,75,1999

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rabbit lethal concentration (50 percent kill): >5100 mg/m3TIHEEC 3,383,1987
inhalation/rat lethal concentration (50 percent kill): >23.4 gm/m3/6HENTOX* -,58,2005
intraperitoneal/rat lowest published toxic dose: 499 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TOXID9 1,54,2001
intraperitoneal/rat lowest published lethal dose: 600 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 48,392,1999
oral/mammal (species unspecified) lethal dose (50 percent kill): 3 gm/kgGUCHAZ 6,3,1973
oral/mouse lethal dose (50 percent kill): 462 mg/kgGTPZAB 21(12),30,1977
oral/rabbit lethal dose (50 percent kill): 1740 mg/kgNNGADV 24,75,1999
oral/rat lethal dose (50 percent kill): 930 mg/kgTIHEEC 3,383,1987
oral/rat lowest published toxic dose: 63 mg/kgOlfaction: Other olfaction effects

Biochemical: Metabolism (intermediary): Other
TOXID9 60,42,2001
skin/rabbit lethal dose (50 percent kill): 3500 mg/kgGUCHAZ 6,3,1973
skin/rat lethal dose (50 percent kill): 1200 mg/kgYKYUA6 38,89,1987
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 1200 mg/kg30ZDA9 -,126,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 300 mg/kg/3D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXAPA9 193,66,2003
oral/Dog lowest published toxic dose: 4725 mg/kg/27W- intermittentLiver: Other changes

Blood: Normocytic anemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NNGADV 24,75,1999
oral/Dog lowest published toxic dose: 1092 mg/kg/1Y- intermittentGastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Normocytic anemia
NNGADV 24,75,1999
oral/Dog lowest published toxic dose: 910 mg/kg/26W- intermittentLiver: Changes in liver weightRCTOE4 104,9,1988
oral/mouse lowest published toxic dose: 2100 mg/kg/21D- intermittentLiver: Liver function tests impaired

Liver: Changes in liver weight
AECTCV 24,449,1993
oral/mouse lowest published toxic dose: 16380 mg/kg/13W- continuousLiver: Changes in liver weightNNGADV 24,75,1999
oral/mouse lowest published toxic dose: 43134 mg/kg/79W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
NNGADV 24,75,1999
oral/rat lowest published toxic dose: 15120 mg/kg/17W- continuousLiver: Changes in liver weight

Endocrine: Changes in thyroid weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
FAATDF 33,16,1996
oral/rat lowest published toxic dose: 10192 mg/kg/2Y- intermittentEye: Corneal damage

Liver: Other changes
RCTOE4 104,9,1988
oral/rat lowest published toxic dose: 15120 mg/kg/120D- continuousLiver: Changes in liver weight

Endocrine: Changes in thyroid weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
FAATDF 33,16,1996
oral/rat lowest published toxic dose: 11550 mg/kg/110W- continuousOlfaction: TumorsHBPTO* 1,814,2001
oral/rat lowest published toxic dose: 1260 mg/kg/10D- continuousOlfaction: Other olfaction effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases
TOPADD 33,593,2005
oral/rat lowest published toxic dose: 1260 mg/kg/10D- continuousOlfaction: Other olfaction effects

Liver: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 -,272,2008
oral/rat lowest published toxic dose: 11466 mg/kg/91D- continuousOlfaction: Other olfaction effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other
TOXID9 -,272,2008
oral/rat lowest published toxic dose: 1260 mg/kg/10D- continuousOlfaction: Other olfaction effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Proteases
FCTOD7 47,1051,2009
oral/rat lowest published toxic dose: 7560 mg/kg/60D- continuousOlfaction: Other olfaction effects

Biochemical: Metabolism (intermediary): Other proteins
FCTOD7 47,1051,2009
unreported route/rat lowest published toxic dose: 539.6 mg/kg/4D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)TOXID9 66,321,2002

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 mg/m3 (inhal, vapor, sen)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,58,2005
TOXICOLOGY REVIEWMUREAV 627,106,2007
TOXICOLOGY REVIEWMUTAEX 20,245,2005
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWFEREAC 71,43906,2006
TOXICOLOGY REVIEWFEREAC 72,39318,2007
TOXICOLOGY REVIEWFEREAC 72,54579,2007
TOXICOLOGY REVIEWREPTED 26,1,2008
TOXICOLOGY REVIEWHUTOX* -,551,1996
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWMUTAEX 26,19,2011
TOXICOLOGY REVIEWMUTAEX 23,207,2008
TOXICOLOGY REVIEWTOLED5 201,152,2011
TOXICOLOGY REVIEWTXCYAC 307,3,2013
TOXICOLOGY REVIEWTXCYAC 307,123,2013
TOXICOLOGY REVIEWTXAPA9 268,157,2013

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,82,1998

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
On EPA IRIS database
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