Phenol, 4,4'-(2-pyridylmethylene)di-, diacetate (ester)

RTECS #
SM8750000
CAS #
603-50-9
See: NMAM or OSHA Methods
Updated
April 2013
Molecular Weight
361.42
Molecular Formula
C22H19NO4
Synonyms
(4,4'-Diacetoxydiphenyl)(2-pyridyl)methane
2-(4,4'-Diacetoxydiphenylmethyl)pyridine
4,4'-(2-Pyridylmethylene)diphenol diacetate
4,4'-Diacetoxydiphenylpyrid-2-ylmethane
Bicol
Bis(p-acetoxyphenyl)-2-pyridylmethane
Bisacodyl
Broxalax
Deficol
Di-(4-acetoxyphenyl)-2-pyridylmethane
Di-(p-acetoxyphenyl)-2-pyridylmethane
Dulcolan
Dulcolax
Durolax
Endokolat
Eulaxan
Godalax
Hillcolax
Ivilax
LA96a
LACO
Laxadin
Laxanin N
Laxans
Laxorex
Neolax
Nigalax
Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate (ester)
Pyrilax
Sanvacual
SK-Bisacodyl
Stadalax
Telemin
Theralax
Ulcolax
Zetrax

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 71400 mg/kg/33W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
JTEHD6 39,59,1993

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intravenous/cat lowest published lethal dose: 40 mg/kgARZNAD 3,19,1953
intravenous/Dog lowest published lethal dose: 40 mg/kgARZNAD 3,19,1953
intravenous/mouse lowest published lethal dose: 80 mg/kgTXAPA9 2,243,1960
intravenous/rabbit lowest published lethal dose: 40 mg/kgARZNAD 3,19,1953
oral/Dog lethal dose (50 percent kill): >15 gm/kgNIIRDN -,854,1990
oral/monkey lowest published toxic dose: 10 mg/kgGastrointestinal: Hypermotility, diarrheaBPBLEO 23,657,2000
oral/mouse lethal dose (50 percent kill): 17500 mg/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation

Blood: Hemorrhage
TXAPA9 2,243,1960
oral/rat lethal dose (50 percent kill): 4320 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Gastrointestinal: Other changes

Blood: Changes in spleen
TXAPA9 2,243,1960

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWDAPOAG 27,151,1975
TOXICOLOGY REVIEWMUREAV 539,77,2003
TOXICOLOGY REVIEWMUREAV 488,151,2001
TOXICOLOGY REVIEWMUREAV 750,1,2012

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code A1651; Number of Industries 2; Total Number of Facilities 132; Number of Occupations 8; Total Number of Employees Exposed 2964; Total Number of Female Employees Exposed 1874
National Occupational Hazard Survey 1974Hazard Code A1651; Number of Industries 1; Total Number of Facilities 86; Number of Occupations 1; Total Number of Employees Exposed 431

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Page last reviewed: November 16, 2018