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Registry of Toxic Effects of Chemical Substances (RTECS)

1H-Indole-3-acetic acid

RTECS #

NL3150000

CAS #

87-51-4

Updated

June 2017

Molecular Weight

175.20

Molecular Formula

C10H9NO2

Synonyms

3-Iaa
3-Indoleacetic acid
3-Indolylacetic acid
Acetic acid, indolyl-
alpha-Indol-3-yl-acetic acid
beta-Indole-3-acetic acid
beta-Indoleacetic acid
beta-Indolylacetic acid
Heteroauxin
Hexteroauxin
IAA
Indol-3-ylacetic acid
Indole-3-acetic acid
Indolyl-3-acetic acid
Kyselina 3-indolyloctova (Czech)
omega-Skatole carboxylic acid
Rhizopin
Rhizopon A

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagesperm/salmon250 µmol/LPYTCAS 11,3135,1972
DNA Damagelymphocyte/mammal (species unspecified)250 µmol/LPYTCAS 11,3135,1972
gene conversion and mitotic recombination/Aspergillus nidulans1150 µmol/LCRNGDP 4,1409,1983
mutation in microorganisms/Escherichia coli120 µg/plate/2HBECTA6 65,691,2000
other mutation test systemsleukocyte/human100 nmol/LEXPEAM 32,29,1976
sex chromosome loss and nondisjunction/Aspergillus nidulans1150 µmol/LCRNGDP 4,1409,1983
sister chromatid exchangelymphocyte/human10 mg/LMUREAV 241,109,1990

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 4500 mg/kg (7-15D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)TJADAB 19,321,1979
oral/rat 450 mg/kg (7-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTJADAB 19,321,1979
oral/mouse 4500 mg/kg (7-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Central nervous system
TJADAB 19,321,1979
oral/mouse 4500 mg/kg (7-15D pregnant)Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 19,321,1979
oral/rat 3000 mg/kg (12-14D pregnant)Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system
TOPADD 32,659,2004
oral/rat 3000 mg/kg (12-14D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)TOPADD 32,659,2004
oral/rat 1500 mg/kg (12-14D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemTOPADD 32,659,2004
oral/mouse 1000 mg/kg (10D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system
ETPAEK 59,43,2007

Tumorigenic Data and References

Route/OrganismDoseEffectReference
subcutaneous/mouse lowest published toxic dose: 2000 mg/kg/20W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumor types after systemic administration not seen spontaneously
AICCA6 19,660,1963

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, colon tumor Inhibitor Concentration (50 percent kill): >30 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FTRPAE 110,103,2016
In Vitro/Human, HeLa cell Inhibitor Concentration (50 percent kill): >30 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FTRPAE 110,103,2016
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): >30 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FTRPAE 110,103,2016
In Vitro/Human, lung tumor Inhibitor Concentration (50 percent kill): >30 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FTRPAE 110,103,2016
In Vitro/jafInhibitor Concentration (50 percent kill): 24.55 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FTRPAE 110,103,2016
In Vitro/jkhInhibitor Concentration (50 percent kill): >30 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FTRPAE 110,103,2016
intraperitoneal/mouse lethal dose (50 percent kill): 150 mg/kgNTIS** AD691-490
oral/rat lowest published toxic dose: 1000 mg/kgNutritional and Gross Metabolic: Weight loss or decreased weight gainTOPADD 32,659,2004
oral/rat Lethal dose: >500 mg/kgNCNSA6 5,7,1953

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 1500 mg/kg/3D- intermittentReproductive: Specific developmental abnormalities: Central nervous system

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOPADD 32,659,2004

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWNRTXDN 44,184,2014

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Hazard Survey 1974Hazard Code 83421; Number of Industries 1; Total Number of Facilities 5; Number of Occupations 1; Total Number of Employees Exposed 27

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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