Cyclopropanecarboxylic acid, 3-(2,2-dibromoethenyl)-2,2-dimethyl-, cyano(3-phenoxyphenyl)methyl ester, (1R-(1-alpha(S*),3-alpha))-
RTECS #
GZ1233000
CAS #
Updated
March 2019
Molecular Weight
505.24
Molecular Formula
C22H19Br2NO3
Synonyms
Butox
Cislin
Crackdown
Decamethrin
Decamethrine
Decis
Dekametrin (Hungarian)
Deltagran
Deltamethrin
Deltamethrine
Deltametryna (Polish)
FMC 45498
K-Othrin
K-Othrine
NRDC 161
OMS 1988
RU 22974
RUP 987
Cislin
Crackdown
Decamethrin
Decamethrine
Decis
Dekametrin (Hungarian)
Deltagran
Deltamethrin
Deltamethrine
Deltametryna (Polish)
FMC 45498
K-Othrin
K-Othrine
NRDC 161
OMS 1988
RU 22974
RUP 987
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 100 µL/24H | NTIS** OTS0545196 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | multiple/other fish | 100 nL/L | JFIBA9 26,13,1985 |
| Cytogenetic Analysis | intraperitoneal/rat | 11200 µg/kg | MUREAV 311,133,1994 |
| Cytogenetic Analysis | subcutaneous/rat | 11200 µg/kg | MUREAV 311,133,1994 |
| Cytogenetic Analysis | oral/rat | 11200 µg/kg | MUREAV 311,133,1994 |
| Cytogenetic Analysis | lymphocyte/human | 10 µmol/L/48H | EMMUEG 48,636,2007 |
| Cytogenetic Analysis | oral/mouse | 6.6 mg/kg | EMMUEG 48,636,2007 |
| Cytogenetic Analysis | oral/rat | 140 mg/kg/4W- intermittent | FCTOD7 50,3421,2012 |
| DNA Damage | oral/rat | 18 mg/kg/30D- intermittent | NETEEC 50,23,2015 |
| DNA Damage | oral/rat | 140 mg/kg/4W- intermittent | FCTOD7 50,3421,2012 |
| DNA inhibition | leukocyte/mouse | 500 µmol/L | DCTODJ 10,291,1987 |
| DNA inhibition | lymphocyte/human | 110 µmol/L | DCTODJ 10,291,1987 |
| Dominant Lethal Test | oral/mouse | 10080 µg/kg/2W-continuous | MUREAV 467,119,2000 |
| micronucleus test | lymphocyte/human | 5 µmol/L/48H | EMMUEG 48,636,2007 |
| micronucleus test | intraperitoneal/mouse | 325 mg/kg/24H-continuous | MUREAV 346,203,1995 |
| micronucleus test | lymphocyte/human | 100 mg/L | MUREAV 341,169,1995 |
| micronucleus test | intraperitoneal/rat | 5600 µg/kg | MUREAV 311,133,1994 |
| other mutation test systems | intraperitoneal/rat | 5600 µg/kg | MUREAV 311,133,1994 |
| other mutation test systems | subcutaneous/rat | 5600 µg/kg | MUREAV 311,133,1994 |
| other mutation test systems | oral/rat | 5600 µg/kg | MUREAV 311,133,1994 |
| sister chromatid exchange | lymphocyte/human | 60 mg/L | MUREAV 283,113,1992 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/rat | 21 mg/kg (21D male) | Reproductive: Other effects on male | TXCYAC 132,1,1999 |
| oral/mouse | 30 mg/kg (7-16D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | JEPTDQ 2(3),751,1979 |
| oral/mouse | 50 mg/kg (8-12D pregnant) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) | TCMUD8 7,7,1987 |
| oral/rat | 0.8 mg/kg (6-15D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral | NETEEC 23,665,2001 |
| oral/rat | 168 mg/kg (1-21D preg/21D after birth) | Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Delayed effects | RTOPDW 36,310,2002 |
| oral/mouse | 57 mg/kg (2W pre-21D after birth) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Biochemical and metabolic | TOXID9 78,379,2004 |
| oral/rat | 450 mg/kg (30D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | INJPD2 37,160,2005 |
| oral/rat | 8.5 mg/kg (5-21D pregnant) | Reproductive: Specific developmental abnormalities: Hepatobiliary system Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral | EJPHAZ 544,58,2006 |
| oral/rat | 4.25 mg/kg (5-21D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic | TXAPA9 214,279,2006 |
| oral/rat | 70 mg/kg (7-20D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | JEPTDQ 2(3),751,1979 |
| oral/rat | 10 mg/kg (6-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | DTTIAF 100,142,1992 |
| oral/rat | 21 mg/kg (1-21D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic | TOXID9 -,351,2009 |
| oral/rat | 28 mg/kg (1-7D pregnant) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on embryo or fetus: Maternal- fetal exchange | FCTOD7 49,2541,2011 |
| subcutaneous/mouse | 10 mg/kg (13D pregnant) | Reproductive: Other developmental abnormalities Reproductive: Effects on newborn: Behavioral | TOXID9 78,378,2004 |
| unreported route/mouse | 63 mg/kg (1-21D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Delayed effects | NETEEC 31,242,2009 |
| unreported route/mouse | 126 mg/kg (21D preg/21D after birth) | Reproductive: Effects on newborn: Behavioral | TOXID9 12,467,2008 |
| unreported route/mouse | 42 mg/kg (1D preg-21D after birth) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Delayed effects | TOXID9 -,37,2009 |
| unreported route/mouse | 4.2 mg/kg (1D preg-21D after birth) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral | TOXID9 44,199,2005 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| skin/mouse | lowest published toxic dose: 384 mg/kg/32W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors Tumorigenic: Tumors at site of application | TXCYAC 163,1,2001 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, colon tumor | Inhibitor Concentration (50 percent kill): 111.9 µmol/L/10D | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOXRE* 1,474,2014 |
| In Vitro/Human, kidney | Inhibitor Concentration Low: 0.1 µmol/L/22M | In Vitro Toxicity Studies: Membrane currents | TXAPA9 291,58,2016 |
| In Vitro/Human, kidney | Inhibitor Concentration (20 percent kill): >100 µmol/L/2H | In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc. | TIVIEQ 40,66,2017 |
| In Vitro/Human, kidney | Inhibitor Concentration (20 percent kill): 45.71 µmol/L/2H | Endocrine: Other changes | TIVIEQ 40,66,2017 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration Low: 50 µmol/L/48H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Other assays | TOLED5 260,8,2016 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration (50 percent kill): 250 µmol/L/48H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOLED5 260,8,2016 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration Low: 100 µmol/L/48H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Apoptosis in vitro | TOLED5 260,8,2016 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration Low: 250 µmol/L | Biochemical: Metabolism (intermediary): Effect on mitochondrial function | TOLED5 260,8,2016 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration Low: 10 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 26,823,2012 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration Low: 10 µmol/L/8H | In Vitro Toxicity Studies: Other assays | TIVIEQ 26,823,2012 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration (50 percent kill): 760 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 26,823,2012 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration Low: 0.1 µmol/L/8D | In Vitro Toxicity Studies: Other assays | FCTOD7 101,149,2017 |
| In Vitro/Mouse, macrophage | Inhibitor Concentration Low: 5 µmol/L/72H | In Vitro Toxicity Studies: Cell differentiation In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 26,817,2012 |
| In Vitro/Mouse, macrophage | Inhibitor Concentration Low: 10 µmol/L/5D | In Vitro Toxicity Studies: Other assays | TIVIEQ 26,817,2012 |
| In Vitro/Mouse, macrophage | Inhibitor Concentration Low: 1.0 µmol/L/72H | In Vitro Toxicity Studies: Cell differentiation | TIVIEQ 26,817,2012 |
| In Vitro/mpe | Inhibitor Concentration Low: 25 µmol/L/72H | In Vitro Toxicity Studies: Cell differentiation In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 26,817,2012 |
| In Vitro/mpe | Inhibitor Concentration Low: 25 µmol/L/60H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | TIVIEQ 26,817,2012 |
| In Vitro/mpe | Inhibitor Concentration Low: 0.1 µmol/L/72H | In Vitro Toxicity Studies: Cell differentiation | TIVIEQ 26,817,2012 |
| In Vitro/nga | Inhibitor Concentration Low: 10 µmol/L/10M | Cardiac: Change in force of contraction | PCBPBS 129,36,2016 |
| In Vitro/nga | Inhibitor Concentration Low: 10 µmol/L | Cardiac: EKG changes not diagnostic of above Cardiac: Change in rate | PCBPBS 129,36,2016 |
| In Vitro/nga | Inhibitor Concentration Low: 10 µmol/L | Nutritional and Gross Metabolic: Changes in: Na In Vitro Toxicity Studies: Membrane currents | PCBPBS 129,36,2016 |
| In Vitro/nga | Inhibitor Concentration (50 percent kill): 1.3 µmol/L | Nutritional and Gross Metabolic: Changes in: Na In Vitro Toxicity Studies: Membrane currents | PCBPBS 129,36,2016 |
| In Vitro/ngb | Inhibitor Concentration Low: 10 µmol/L/10M | Cardiac: Change in force of contraction Cardiac: Change in rate | PCBPBS 129,36,2016 |
| In Vitro/Rat, neurons | Inhibitor Concentration (50 percent kill): 0.9 µmol/L/20M | In Vitro Toxicity Studies: Other assays | NETOX* 48,152,2015 |
| In Vitro/Rat, neurons | Inhibitor Concentration (50 percent kill): 0.19 µmol/L/10M | In Vitro Toxicity Studies: Other assays | NRTXDN 40,75,2014 |
| inhalation/mammal (species unspecified) | lethal concentration (50 percent kill): 2.2 gm/m3/4H | FEREAC 63,45408,1998 | |
| inhalation/rat | lethal concentration (50 percent kill): 785 mg/m3/2H | Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands | JEPTDQ 2(3),751,1979 |
| intracerebral/mouse | lethal dose (50 percent kill): 26100 µg/kg | PCBPBS 24,200,1985 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 10 mg/kg | EVHPAZ 21,285,1977 | |
| intraperitoneal/rat | lowest published toxic dose: 10 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Other | TOXID9 44,402,2005 |
| intraperitoneal/rat | lowest published toxic dose: 60 mg/kg | Eye: Lacrimation Behavioral: Excitement Gastrointestinal: Changes in structure or function of salivary glands | TXCYAC 243,155,2008 |
| intraperitoneal/rat | lowest published toxic dose: 20 mg/kg | Brain and Coverings: Other degenerative changes | TXCYAC 243,155,2008 |
| intravenous/Dog | lethal dose (50 percent kill): 3440 µg/kg | Behavioral: Tremor Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands | IJTEDP 6,127,1984 |
| intravenous/rabbit | lethal dose (50 percent kill): 1350 mg/kg | NAYXEW 10,115,1990 | |
| intravenous/rat | lowest published toxic dose: 0.05 mg/kg | Endocrine: Adrenal cortex hyperplasia | TXCYAC 49,263,1988 |
| intravenous/rat | lowest published toxic dose: 0.15 mg/kg | Behavioral: Alteration of classical conditioning Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS | TXCYAC 49,263,1988 |
| intravenous/rat | lethal dose (50 percent kill): 2526 µg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Gastrointestinal: Changes in structure or function of salivary glands | PCBPBS 30,79,1988 |
| intravenous/rat | lowest published toxic dose: 1 mg/kg | Gastrointestinal: Changes in structure or function of salivary glands | TOXID9 44,255,2005 |
| intravenous/rat | lethal dose (50 percent kill): 2.6 mg/kg | TXAPA9 216,354,2006 | |
| intravenous/rat | lowest published toxic dose: 2 mg/kg | Behavioral: Tremor Gastrointestinal: Changes in structure or function of salivary glands | TXCYAC 234,194,2007 |
| oral/Dog | lethal dose (50 percent kill): >300 gm/kg | PEMNDP 9,232,1991 | |
| oral/duck | lethal dose (50 percent kill): >4640 mg/kg | PEMNDP 9,232,1991 | |
| oral/mammal (species unspecified) | lethal dose (50 percent kill): 5000 mg/kg | FEREAC 63,45408,1998 | |
| oral/mouse | lethal dose (50 percent kill): 20 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold Kidney, Ureter, and Bladder: Urine volume increased | JEBIDP 12,45,1991 |
| oral/mouse | lowest published toxic dose: 0.7 mg/kg | Brain and Coverings: Other degenerative changes Behavioral: Change in motor activity (specific assay) | FEREAC 69,62602,2004 |
| oral/mouse | lethal dose (50 percent kill): 33 mg/kg | EMMUEG 48,636,2007 | |
| oral/rat | lowest published toxic dose: 10 mg/kg | Behavioral: Tremor Gastrointestinal: Changes in structure or function of salivary glands | TXCYAC 234,194,2007 |
| oral/rat | lowest published toxic dose: 3 mg/kg | Brain and Coverings: Other degenerative changes | TOXID9 12,468,2008 |
| oral/rat | lowest published toxic dose: 2.5 mg/kg | Cardiac: EKG changes not diagnostic of above | TXAPA9 282,184,2015 |
| oral/rat | lowest published toxic dose: 5.5 mg/kg | Cardiac: EKG changes not diagnostic of above Nutritional and Gross Metabolic: Body temperature decrease | TXAPA9 282,184,2015 |
| oral/rat | lowest published toxic dose: 5.5 mg/kg | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TXAPA9 282,161,2015 |
| oral/rat | lowest published toxic dose: 10 mg/kg | Behavioral: Change in psychophysiological tests | NETEEC 46,57,2014 |
| oral/rat | lowest published toxic dose: 2 mg/kg | Nutritional and Gross Metabolic: Body temperature decrease | TOXID9 90,117,2006 |
| oral/rat | lowest published lethal dose: 10 mg/kg | Gastrointestinal: Changes in structure or function of salivary glands | TOXID9 90,117,2006 |
| oral/rat | lowest published toxic dose: 2 mg/kg | Behavioral: Food intake (animal) | TOXID9 90,117,2006 |
| oral/rat | lowest published lethal dose: 10 mg/kg | Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOXID9 90,117,2006 |
| oral/rat | lowest published toxic dose: 10 mg/kg | Gastrointestinal: Changes in structure or function of salivary glands | TOXID9 44,255,2005 |
| oral/rat | lowest published lethal dose: 10 mg/kg | Behavioral: Tremor | TOXID9 44,255,2005 |
| oral/rat | lowest published toxic dose: 3 mg/kg | Cardiac: Arrythmias (indlucing changes in conduction) | TOXID9 90,303,2006 |
| oral/rat | lowest published toxic dose: 7.2 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOVEFN (3),15,1993 |
| oral/rat | lethal dose (50 percent kill): 150 mg/kg | Behavioral: Tremor Lung, Thorax, or Respiration: Respiratory depression Gastrointestinal: Changes in structure or function of salivary glands | INJPD2 37,160,2005 |
| oral/rat | lethal dose (50 percent kill): 5.1 mg/kg | HBPTO* 1,881,2001 | |
| oral/rat | lowest published toxic dose: 10 mg/kg | Behavioral: Tremor | FCTOD7 41,431,2003 |
| oral/rat | lowest published toxic dose: 1 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Other | TOXID9 44,443,2005 |
| oral/rat | lowest published toxic dose: 30 mg/kg | Brain and Coverings: Other degenerative changes Gastrointestinal: Changes in structure or function of salivary glands | TOXID9 78,228,2004 |
| oral/rat | lowest published toxic dose: 1 mg/kg | Eye: Lacrimation Behavioral: Change in motor activity (specific assay) Gastrointestinal: Changes in structure or function of salivary glands | TOXID9 1,112,2001 |
| oral/rat | lowest published toxic dose: 2 mg/kg | Behavioral: Change in motor activity (specific assay) | FEREAC 69,62602,2004 |
| oral/rat | lethal dose (50 percent kill): 9360 µg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold Kidney, Ureter, and Bladder: Urine volume increased | JEBIDP 12,45,1991 |
| skin/mammal (species unspecified) | lethal dose (50 percent kill): 2000 mg/kg | FEREAC 63,45408,1998 | |
| skin/mouse | lowest published toxic dose: 4 mg/kg | Skin and Appendages: Tumors Tumorigenic: Facilitates action of known carcinogens | TXCYAC 163,1,2001 |
| skin/rabbit | lethal dose (50 percent kill): 2 gm/kg | DEVEAA 33,76,1979 | |
| skin/rat | lethal dose (50 percent kill): >800 mg/kg | JEPTDQ 2(3),751,1979 | |
| Tank with water/Carp | lowest published toxic concentration: 2 µg/L/3D | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | TIVIEQ 33,279,1995 |
| Tank with water/Zooplankton | lethal concentration (50 percent kill): 0.0472 µg/L/24H | CMSHAF 144,599,2016 | |
| unreported route/rat | lethal dose (50 percent kill): 150 mg/kg | TOXID9 44,174,2005 | |
| unreported route/rat | lowest published lethal dose: 10 mg/kg | Behavioral: Change in motor activity (specific assay) | TOXID9 90,292,2006 |
| unreported route/rat | lowest published toxic dose: 10 mg/kg | Behavioral: Change in motor activity (specific assay) | TOXID9 90,292,2006 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 201.6 mg/kg/21D- intermittent | Behavioral: Excitement Skin: After systemic exposure: Dermatitis, irritative Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FEREAC 69,62602,2004 |
| inhalation/rat | lowest published toxic concentration: 6 mg/m3/45D- intermittent | Lung, Thorax, or Respiration: Emphysema Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | EESADV 63,318,2006 |
| intraperitoneal/mouse | lowest published toxic dose: 9 mg/kg/15D- intermittent | Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum | TXAPA9 211,188,2006 |
| intraperitoneal/mouse | lowest published toxic dose: 18 mg/kg/15D- intermittent | Behavioral: Change in motor activity (specific assay) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum | TOXID9 78,279,2004 |
| intraperitoneal/rat | lowest published toxic dose: 3.5 mg/kg/5D- intermittent | Behavioral: Change in motor activity (specific assay) Behavioral: Change in psychophysiological tests | NETEEC 31,169,2009 |
| intraperitoneal/rat | lowest published toxic dose: 20 mg/kg/30D- intermittent | Behavioral: Somnolence (general depressed activity) Behavioral: Food intake (animal) Reproductive: Paternal effects: Testes, epididymis, sperm duct | TOXRE* 1,401,2014 |
| intraperitoneal/rat | lowest published toxic dose: 20 mg/kg/30D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOXRE* 1,401,2014 |
| intraperitoneal/rat | lowest published toxic dose: 3.5 mg/kg/5D- intermittent | Vascular: Other changes Reproductive: Specific developmental abnormalities: Central nervous system | HBPTO* 2,1298,2001 |
| intraperitoneal/rat | lowest published toxic dose: 240 mg/kg/6D- intermittent | Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS | TOXID9 72,306,2003 |
| intraperitoneal/rat | lowest published toxic dose: 35 mg/kg/7D- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | JEPOEC 14,45,1995 |
| oral/mammal (species unspecified) | lowest published toxic dose: 504 mg/kg/84D- intermittent | Immunological Including Allergic: Decrease in cellular immune response Immunological Including Allergic: Decrease in humoral immune response | HBPTO* 1,777,2001 |
| oral/mammal (species unspecified) | lowest published toxic dose: 210 mg/kg/14D- intermittent | Immunological Including Allergic: Decrease in cellular immune response Immunological Including Allergic: Decrease in humoral immune response | HBPTO* 1,777,2001 |
| oral/mouse | lowest published toxic dose: 39 mg/kg/13W- intermittent | Cardiac: Changes in heart weight Liver: Changes in liver weight Endocrine: Changes in spleen weight | JEBIDP 12,45,1991 |
| oral/mouse | lowest published toxic dose: 210 mg/kg/2W- intermittent | Blood: Other changes Immunological Including Allergic: Decrease in cellular immune response Immunological Including Allergic: Decrease in humoral immune response | ENVRAL 59,467,1992 |
| oral/mouse | lowest published toxic dose: 9 mg/kg/15D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Other proteins | TOXID9 12,467,2008 |
| oral/mouse | lowest published toxic dose: 175 mg/kg/5W- intermittent | Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | TOXRE* 3,584,2016 |
| oral/mouse | lowest published toxic dose: 135 mg/kg/45D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | APJRE* 5,24,2016 |
| oral/mouse | lowest published toxic dose: 135 mg/kg/45D- intermittent | Biochemical: Metabolism (intermediary): Other carbohydrates Biochemical: Metabolism (intermediary): Other | APJRE* 5,24,2016 |
| oral/quail | lowest published toxic dose: 1228 mg/kg/7D- continuous | Gastrointestinal: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | BECTA6 31,479,1983 |
| oral/rat | lowest published toxic dose: 12500 µg/kg/10D- intermittent | Behavioral: Food intake (animal) Liver: Other changes | WDZAEK 8,189,1994 |
| oral/rat | lowest published toxic dose: 105 mg/kg/15D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTEHD6 48,515,1996 |
| oral/rat | lowest published toxic dose: 450 mg/kg/30D- intermittent | Kidney, Ureter, and Bladder: Urine volume increased Kidney, Ureter, and Bladder: Proteinuria | BCTKAG 21,146,1988 |
| oral/rat | lowest published toxic dose: 140 mg/kg/7D- intermittent | Peripheral Nerve and Sensation: Recording from peripheral motor nerve Behavioral: Muscle weakness Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | ARTODN 53,297,1983 |
| oral/rat | lowest published toxic dose: 450 mg/kg/30D- intermittent | Endocrine: Hyperglycemia Blood: Hemorrhage Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | INJPD2 37,160,2005 |
| oral/rat | lowest published toxic dose: 38.4 mg/kg/30D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Biochemical: Metabolism (intermediary): Lipids including transport | TOXID9 227,240,2006 |
| oral/rat | lowest published toxic dose: 18.0 mg/kg/18D- intermittent | Behavioral: Alteration of classical conditioning Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NETEEC 61,138,2017 |
| oral/rat | lowest published toxic dose: 9.0 mg/kg/18D- intermittent | Behavioral: Alteration of classical conditioning Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NETEEC 61,138,2017 |
| oral/rat | lowest published toxic dose: 140 mg/kg/4W- intermittent | Endocrine: Change in LH Endocrine: Other changes Reproductive: Paternal effects: Testes, epididymis, sperm duct | FCTOD7 50,3421,2012 |
| oral/rat | lowest published toxic dose: 18 mg/kg/30D- intermittent | Brain and Coverings: Other degenerative changes | NETEEC 50,23,2015 |
| skin/rat | lowest published toxic dose: 0.78 mg/kg/60D- intermittent | Endocrine: Other changes Related to Chronic Data: Changes in ovarian weight | FCLPH* 23(Suppl 1),68,2009 |
| unreported route/non-mammalian species | lowest published toxic dose: 5052.4 mg/m3/7D- continuous | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Other effects to embryo or fetus Biochemical: Metabolism (intermediary): Lipids including transport | FCTOD7 101,149,2017 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMEMDT 53,251,1991 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human No Available Data | IMEMDT 53,251,1991 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMEMDT 53,251,1991 |
| TOXICOLOGY REVIEW | MUREAV 557,109,2004 | |
| TOXICOLOGY REVIEW | TOLED5 127,29,2002 | |
| TOXICOLOGY REVIEW | TOLED5 134,3,2002 | |
| TOXICOLOGY REVIEW | TOLED5 142,207,2003 | |
| TOXICOLOGY REVIEW | MUTAEX 21,93,2006 | |
| TOXICOLOGY REVIEW | ENTOX* -,736,2005 | |
| TOXICOLOGY REVIEW | TOXIA6 49,452,2007 | |
| TOXICOLOGY REVIEW | HUTOX* -,541,1996 | |
| TOXICOLOGY REVIEW | NETEEC 30,55,2008 | |
| TOXICOLOGY REVIEW | MUREAV 681,93,2009 | |
| TOXICOLOGY REVIEW | TPHSDY 29,322,2008 | |
| TOXICOLOGY REVIEW | REPTED 26,13,2008 | |
| TOXICOLOGY REVIEW | MUTAEX 26,19,2011 | |
| TOXICOLOGY REVIEW | MUTAEX 21,343,2006 | |
| TOXICOLOGY REVIEW | MUREAV 721,27,2011 | |
| TOXICOLOGY REVIEW | NRTXDN 32,383,2011 | |
| TOXICOLOGY REVIEW | TXCYAC 307,3,2013 | |
| TOXICOLOGY REVIEW | TXCYAC 307,24,2013 | |
| TOXICOLOGY REVIEW | TOLED5 230,85,2014 | |
| TOXICOLOGY REVIEW | NETEEC 36,17,2013 | |
| TOXICOLOGY REVIEW | TXAPA9 268,157,2013 | |
| TOXICOLOGY REVIEW | NETEEC 52,25,2015 | |
| TOXICOLOGY REVIEW | NETEEC 52,68,2015 | |
| TOXICOLOGY REVIEW | TIVIEQ 34,321,2016 | |
| TOXICOLOGY REVIEW | FCTOD7 105,456,2017 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Active registration | RBREV* -,363,1998 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| On EPA IRIS database |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health