Benzoic acid, sodium salt

RTECS #

DH6650000

CAS #

532-32-1
See: NMAM or OSHA Methods

Updated

October 2017

Molecular Weight

144.11

Molecular Formula

C₇H₅O₂·Na

Synonyms

Antimol
Benzoan sodny (Czech)
Benzoate of soda
Benzoate sodium
Benzoesaeure (na-salz) (German)
E 211
Sobenate
Sodium benzoate
Sodium benzoic acid

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /human	10%/1H open irritation test		DERAAC 26,734,1984
skin /human	0.5%/20M		JAADDB 26,734,1984

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	lung/hamster	1 gm/L	ATSUDG 4,41,1980
Cytogenetic Analysis	fibroblast/hamster	2 gm/L/48H	MUREAV 48,337,1977
Cytogenetic Analysis	lymphocyte/human	6.25 mg/L/24H	FCTOD7 49,763,2011
DNA Damage	lymphocyte/human	6.25 mg/L/1H	FCTOD7 49,763,2011
micronucleus test	lymphocyte/human	25 mg/L/48H	FCTOD7 49,763,2011
sister chromatid exchange	lymphocyte/human	10 mmol/L	MUREAV 241,109,1990
sister chromatid exchange	lymphocyte/human	6.25 mg/L/24H	FCTOD7 49,763,2011
sister chromatid exchange	lymphocyte/human	8 mmol/L/72H	FCTOD7 46,2390,2008

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/rat	3 gm/kg (12-14D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TXAPA9 19,373,1971
intraperitoneal/rat	300 mg/kg (12-14D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death	TXAPA9 19,373,1971
oral/rat	44 gm/kg (1-22D pregnant)	Reproductive: Specific developmental abnormalities: Homeostasis Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Musculoskeletal system	ESKHA5 (96),47,1978
oral/rat	44 gm/kg (1-22D pregnant)	Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)	ESKHA5 (96),47,1978

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/mzx	Inhibitor Concentration Low: 2500 mg/L/72H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	FCTOD7 88,40,2016
In Vitro/mzx	Inhibitor Concentration Low: 1000 mg/L/72H	In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.	FCTOD7 88,40,2016
In Vitro/mzx	Inhibitor Concentration Low: 1000 mg/L/48H	Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	FCTOD7 88,40,2016
In Vitro/Rabbit, ocular	Inhibitor Concentration (50 percent kill): 0.03 gm/L/10M	In Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay	TIVIEQ 3,329,1989
intramuscular/mouse	lethal dose (50 percent kill): 2306 mg/kg		JPETAB 117,307,1956
intraperitoneal/guinea pig	lowest published lethal dose: 1400 mg/kg		HBAMAK 4,1313,1935
intravenous/mouse	lethal dose (50 percent kill): 1440 mg/kg		MECHAN 6,290,1963
intravenous/rat	lethal dose (50 percent kill): 1714 mg/kg	Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold	JAPMA8 31,253,1942
oral/Dog	lethal dose (50 percent kill): 2 gm/kg		FAONAU 53A,34,1974
oral/mouse	lethal dose (50 percent kill): 1600 mg/kg	Behavioral: Change in motor activity (specific assay) Lung, Thorax, or Respiration: Dyspnea	GISAAA 51(1),75,1986
oral/rabbit	lethal dose (50 percent kill): 2 gm/kg		FAONAU 53A,34,1974
oral/rat	lethal dose (50 percent kill): 4070 mg/kg		JIHTAB 30,63,1948
subcutaneous/frog	lowest published lethal dose: 100 mg/kg		HBAMAK 4,1313,1935
subcutaneous/guinea pig	lowest published lethal dose: 1 gm/kg		GISAAA 28(1),45,1963
subcutaneous/rabbit	lethal dose (50 percent kill): 2 gm/kg		FAONAU 53A,34,1974
subcutaneous/rat	lethal dose (50 percent kill): 2 gm/kg		GISAAA 28(1),45,1963

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	lowest published toxic dose: 45 gm/kg/10D- continuous	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	TOLED5 69,171,1993
oral/rat	lowest published toxic dose: 35200 mg/kg/22D- intermittent	Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV141 -,-,2001
oral/rat	lowest published toxic dose: 27370 mg/kg/10D- continuous	Liver: Changes in liver weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Other proteins	TOLED5 69,171,1993
oral/rat	lowest published toxic dose: 84 gm/kg/28D- continuous	Behavioral: Convulsions or effect on seizure threshold Kidney, Ureter, and Bladder: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	AIPTAK 144,120,1963
oral/rat	lowest published toxic dose: 137 gm/kg/13W- continuous	Behavioral: Convulsions or effect on seizure threshold Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TRENAF 42,285,1991

Reviews

Organization	Standard	Reference
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		HUTOX* -,259,1996
TOXICOLOGY REVIEW		TXAPA9 243,225,2010
TOXICOLOGY REVIEW		FCTOD7 84,133,2015
TOXICOLOGY REVIEW		MUREAV 802,1,2016
TOXICOLOGY REVIEW		FCTOD7 97,S180,2016

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Cancelled	RBREV* -,297,1998
Occupational Exposure Limit-RUSSIA	short term exposure limit 5 mg/m³, JUN2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code X1192; Number of Industries 2; Total Number of Facilities 31; Number of Occupations 2; Total Number of Employees Exposed 430; Total Number of Female Employees Exposed 288
National Occupational Exposure Survey 1983	Hazard Code 80214; Number of Industries 143; Total Number of Facilities 20457; Number of Occupations 125; Total Number of Employees Exposed 533161; Total Number of Female Employees Exposed 199915
National Occupational Hazard Survey 1974	Hazard Code 80214; Number of Industries 84; Total Number of Facilities 13289; Number of Occupations 69; Total Number of Employees Exposed 92390

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Negative: TRP reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health