Benzoic acid, sodium salt

RTECS #

DH6650000

CAS #

532-32-1
See: NMAM or OSHA Methods

Updated

March 2019

Molecular Weight

144.11

Molecular Formula

C₇H₅O₂·Na

Synonyms

Antimol
Benzoan sodny (Czech)
Benzoate of soda
Benzoate sodium
Benzoesaeure (na-salz) (German)
E 211
Sobenate
Sodium benzoate
Sodium benzoic acid

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /human	10%/1H open irritation test		DERAAC 26,734,1984
skin /human	0.5%/20M		JAADDB 26,734,1984

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	lung/hamster	1 gm/L	ATSUDG 4,41,1980
Cytogenetic Analysis	fibroblast/hamster	2 gm/L/48H	MUREAV 48,337,1977
Cytogenetic Analysis	lymphocyte/human	6.25 mg/L/24H	FCTOD7 49,763,2011
DNA Damage	lymphocyte/human	6.25 mg/L/1H	FCTOD7 49,763,2011
micronucleus test	lymphocyte/human	25 mg/L/48H	FCTOD7 49,763,2011
sister chromatid exchange	lymphocyte/human	10 mmol/L	MUREAV 241,109,1990
sister chromatid exchange	lymphocyte/human	6.25 mg/L/24H	FCTOD7 49,763,2011
sister chromatid exchange	lymphocyte/human	8 mmol/L/72H	FCTOD7 46,2390,2008

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/rat	3 gm/kg (12-14D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TXAPA9 19,373,1971
intraperitoneal/rat	300 mg/kg (12-14D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death	TXAPA9 19,373,1971
oral/rat	44 gm/kg (1-22D pregnant)	Reproductive: Specific developmental abnormalities: Homeostasis Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Musculoskeletal system	ESKHA5 (96),47,1978
oral/rat	44 gm/kg (1-22D pregnant)	Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)	ESKHA5 (96),47,1978

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/mzx	Inhibitor Concentration Low: 2500 mg/L/72H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	FCTOD7 88,40,2016
In Vitro/mzx	Inhibitor Concentration Low: 1000 mg/L/72H	In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.	FCTOD7 88,40,2016
In Vitro/mzx	Inhibitor Concentration Low: 1000 mg/L/48H	Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	FCTOD7 88,40,2016
In Vitro/Rabbit, ocular	Inhibitor Concentration (50 percent kill): 0.03 gm/L/10M	In Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay	TIVIEQ 3,329,1989
intramuscular/mouse	lethal dose (50 percent kill): 2306 mg/kg		JPETAB 117,307,1956
intraperitoneal/guinea pig	lowest published lethal dose: 1400 mg/kg		HBAMAK 4,1313,1935
intravenous/mouse	lethal dose (50 percent kill): 1440 mg/kg		MECHAN 6,290,1963
intravenous/rat	lethal dose (50 percent kill): 1714 mg/kg	Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold	JAPMA8 31,253,1942
oral/Dog	lethal dose (50 percent kill): 2 gm/kg		FAONAU 53A,34,1974
oral/mouse	lethal dose (50 percent kill): 1600 mg/kg	Behavioral: Change in motor activity (specific assay) Lung, Thorax, or Respiration: Dyspnea	GISAAA 51(1),75,1986
oral/rabbit	lethal dose (50 percent kill): 2 gm/kg		FAONAU 53A,34,1974
oral/rat	lethal dose (50 percent kill): 4070 mg/kg		JIHTAB 30,63,1948
subcutaneous/frog	lowest published lethal dose: 100 mg/kg		HBAMAK 4,1313,1935
subcutaneous/guinea pig	lowest published lethal dose: 1 gm/kg		GISAAA 28(1),45,1963
subcutaneous/rabbit	lethal dose (50 percent kill): 2 gm/kg		FAONAU 53A,34,1974
subcutaneous/rat	lethal dose (50 percent kill): 2 gm/kg		GISAAA 28(1),45,1963

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	lowest published toxic dose: 45 gm/kg/10D- continuous	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	TOLED5 69,171,1993
oral/rat	lowest published toxic dose: 35200 mg/kg/22D- intermittent	Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV141 -,-,2001
oral/rat	lowest published toxic dose: 27370 mg/kg/10D- continuous	Liver: Changes in liver weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Other proteins	TOLED5 69,171,1993
oral/rat	lowest published toxic dose: 84 gm/kg/28D- continuous	Behavioral: Convulsions or effect on seizure threshold Kidney, Ureter, and Bladder: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	AIPTAK 144,120,1963
oral/rat	lowest published toxic dose: 137 gm/kg/13W- continuous	Behavioral: Convulsions or effect on seizure threshold Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TRENAF 42,285,1991

Reviews

Organization	Standard	Reference
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		HUTOX* -,259,1996
TOXICOLOGY REVIEW		TXAPA9 243,225,2010
TOXICOLOGY REVIEW		FCTOD7 84,133,2015
TOXICOLOGY REVIEW		MUREAV 802,1,2016
TOXICOLOGY REVIEW		FCTOD7 97,S180,2016
TOXICOLOGY REVIEW		SFDRA* 38,523,2016

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Cancelled	RBREV* -,297,1998
Occupational Exposure Limit-RUSSIA	short term exposure limit 5 mg/m³, JUN2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code X1192; Number of Industries 2; Total Number of Facilities 31; Number of Occupations 2; Total Number of Employees Exposed 430; Total Number of Female Employees Exposed 288
National Occupational Exposure Survey 1983	Hazard Code 80214; Number of Industries 143; Total Number of Facilities 20457; Number of Occupations 125; Total Number of Employees Exposed 533161; Total Number of Female Employees Exposed 199915
National Occupational Hazard Survey 1974	Hazard Code 80214; Number of Industries 84; Total Number of Facilities 13289; Number of Occupations 69; Total Number of Employees Exposed 92390

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Negative: TRP reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health