Benzoic acid, sodium salt
RTECS #
DH6650000
CAS #
Updated
March 2019
Molecular Weight
144.11
Molecular Formula
C7H5O2·Na
Synonyms
Antimol
Benzoan sodny (Czech)
Benzoate of soda
Benzoate sodium
Benzoesaeure (na-salz) (German)
E 211
Sobenate
Sodium benzoate
Sodium benzoic acid
Benzoan sodny (Czech)
Benzoate of soda
Benzoate sodium
Benzoesaeure (na-salz) (German)
E 211
Sobenate
Sodium benzoate
Sodium benzoic acid
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
skin /human | 10%/1H open irritation test | DERAAC 26,734,1984 | |
skin /human | 0.5%/20M | JAADDB 26,734,1984 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | lung/hamster | 1 gm/L | ATSUDG 4,41,1980 |
Cytogenetic Analysis | fibroblast/hamster | 2 gm/L/48H | MUREAV 48,337,1977 |
Cytogenetic Analysis | lymphocyte/human | 6.25 mg/L/24H | FCTOD7 49,763,2011 |
DNA Damage | lymphocyte/human | 6.25 mg/L/1H | FCTOD7 49,763,2011 |
micronucleus test | lymphocyte/human | 25 mg/L/48H | FCTOD7 49,763,2011 |
sister chromatid exchange | lymphocyte/human | 10 mmol/L | MUREAV 241,109,1990 |
sister chromatid exchange | lymphocyte/human | 6.25 mg/L/24H | FCTOD7 49,763,2011 |
sister chromatid exchange | lymphocyte/human | 8 mmol/L/72H | FCTOD7 46,2390,2008 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/rat | 3 gm/kg (12-14D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TXAPA9 19,373,1971 |
intraperitoneal/rat | 300 mg/kg (12-14D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death | TXAPA9 19,373,1971 |
oral/rat | 44 gm/kg (1-22D pregnant) | Reproductive: Specific developmental abnormalities: Homeostasis Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Musculoskeletal system | ESKHA5 (96),47,1978 |
oral/rat | 44 gm/kg (1-22D pregnant) | Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) | ESKHA5 (96),47,1978 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/mzx | Inhibitor Concentration Low: 2500 mg/L/72H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | FCTOD7 88,40,2016 |
In Vitro/mzx | Inhibitor Concentration Low: 1000 mg/L/72H | In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. | FCTOD7 88,40,2016 |
In Vitro/mzx | Inhibitor Concentration Low: 1000 mg/L/48H | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | FCTOD7 88,40,2016 |
In Vitro/Rabbit, ocular | Inhibitor Concentration (50 percent kill): 0.03 gm/L/10M | In Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay | TIVIEQ 3,329,1989 |
intramuscular/mouse | lethal dose (50 percent kill): 2306 mg/kg | JPETAB 117,307,1956 | |
intraperitoneal/guinea pig | lowest published lethal dose: 1400 mg/kg | HBAMAK 4,1313,1935 | |
intravenous/mouse | lethal dose (50 percent kill): 1440 mg/kg | MECHAN 6,290,1963 | |
intravenous/rat | lethal dose (50 percent kill): 1714 mg/kg | Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold | JAPMA8 31,253,1942 |
oral/Dog | lethal dose (50 percent kill): 2 gm/kg | FAONAU 53A,34,1974 | |
oral/mouse | lethal dose (50 percent kill): 1600 mg/kg | Behavioral: Change in motor activity (specific assay) Lung, Thorax, or Respiration: Dyspnea | GISAAA 51(1),75,1986 |
oral/rabbit | lethal dose (50 percent kill): 2 gm/kg | FAONAU 53A,34,1974 | |
oral/rat | lethal dose (50 percent kill): 4070 mg/kg | JIHTAB 30,63,1948 | |
subcutaneous/frog | lowest published lethal dose: 100 mg/kg | HBAMAK 4,1313,1935 | |
subcutaneous/guinea pig | lowest published lethal dose: 1 gm/kg | GISAAA 28(1),45,1963 | |
subcutaneous/rabbit | lethal dose (50 percent kill): 2 gm/kg | FAONAU 53A,34,1974 | |
subcutaneous/rat | lethal dose (50 percent kill): 2 gm/kg | GISAAA 28(1),45,1963 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/mouse | lowest published toxic dose: 45 gm/kg/10D- continuous | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | TOLED5 69,171,1993 |
oral/rat | lowest published toxic dose: 35200 mg/kg/22D- intermittent | Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV141 -,-,2001 |
oral/rat | lowest published toxic dose: 27370 mg/kg/10D- continuous | Liver: Changes in liver weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Other proteins | TOLED5 69,171,1993 |
oral/rat | lowest published toxic dose: 84 gm/kg/28D- continuous | Behavioral: Convulsions or effect on seizure threshold Kidney, Ureter, and Bladder: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AIPTAK 144,120,1963 |
oral/rat | lowest published toxic dose: 137 gm/kg/13W- continuous | Behavioral: Convulsions or effect on seizure threshold Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TRENAF 42,285,1991 |
Reviews
Organization | Standard | Reference |
---|---|---|
TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
TOXICOLOGY REVIEW | HUTOX* -,259,1996 | |
TOXICOLOGY REVIEW | TXAPA9 243,225,2010 | |
TOXICOLOGY REVIEW | FCTOD7 84,133,2015 | |
TOXICOLOGY REVIEW | MUREAV 802,1,2016 | |
TOXICOLOGY REVIEW | FCTOD7 97,S180,2016 | |
TOXICOLOGY REVIEW | SFDRA* 38,523,2016 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Cancelled | RBREV* -,297,1998 |
Occupational Exposure Limit-RUSSIA | short term exposure limit 5 mg/m3, JUN2003 |
NIOSH Documentation and Surveillance
Status in Federal Agencies
Organization | Reference |
---|---|
EPA GENETOX PROGRAM 1988, Negative: TRP reversion | |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health