Benzoic acid

RTECS #
DG0875000
CAS #
65-85-0
See: NMAM or OSHA Methods
Updated
December 2017
Molecular Weight
122.13
Molecular Formula
C7H6O2
Synonyms
Acide benzoique (French)
Acido benzoico (Italian)
Benzenecarboxylic acid
Benzeneformic acid
Benzenemethanoic acid
Benzoate
Benzoesaeure (German)
Carboxybenzene
Dracylic acid
E 210
HA 1 (acid)
Kyselina benzoova (Czech)
Phenylcarboxylic acid
Phenylformic acid
Retarder BA
Retardex
Salvo liquid
Salvo powder
Tenn-Plas

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 22 mg/3D- intermittent moderate85DKA8 -,127,1977
skin /human 0.25%/1H open irritation testADVEA4 26,734,1984
skin /human 0.76%/40M mildCODEDG 33,177,1995

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagelymphocyte/human5 mmol/LFCTOD7 48,1239,2010
DNA inhibitionlymphocyte/human5 mmol/LPNASA6 79,1171,1982
mutation in microorganisms/Escherichia coli10 mmol/L (-enzymatic activation step)ZBPIA9 112,226,1959
other mutation test systemsoral/Drosophila melanogaster50 mmol/LFCTOD7 46,1034,2008

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/hpcInhibitor Concentration Low: 0.25 gm/L/30MIn Vitro Toxicity Studies: Other assaysJOETD7 137,914,2011
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 21 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Human, lymphocyte Inhibitor Concentration (30 percent kill): >200 mg/L/45HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TIVIEQ 29,901,2015
In Vitro/Human, lymphocyte Inhibitor Concentration (50 percent kill): >200 mg/L/45HIn Vitro Toxicity Studies: Other assaysTIVIEQ 29,901,2015
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): >2000 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXAPA9 245,281,2010
intraperitoneal/guinea pig lowest published lethal dose: 1400 mg/kgHBTXAC 5,23,1959
intraperitoneal/mouse lethal dose (50 percent kill): 1460 mg/kgCRSBAW 160,1097,1966
intraperitoneal/rat lethal dose (50 percent kill): 1600 mg/kgBCFAAI 112,53,1973
intravenous/rat lethal dose (50 percent kill): 1700 mg/kgAPYPAY 12,173,1961
oral/guinea pig lowest published lethal dose: 2 gm/kgMMWOAU 77,13,1930
oral/man lowest published lethal dose: 500 mg/kgFCTXAV 17,715,1979
oral/mouse lethal dose (50 percent kill): 1940 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Other changes
IYKEDH 15,359,1984
oral/rabbit lowest published lethal dose: 2 gm/kgHBTXAC 5,23,1959
oral/rat lethal dose (50 percent kill): 1700 mg/kgIPSTB3 3,93,1976
skin/human lowest published toxic dose: 6 mg/kgLung, Thorax, or Respiration: Dyspnea

Skin: After systemic exposure: Dermatitis, allergic
JOALAS 16,195,1945
subcutaneous/frog lowest published lethal dose: 100 mg/kgHBTXAC 5,23,1959
subcutaneous/rabbit lowest published lethal dose: 2 gm/kgHBTXAC 5,23,1959

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1200 mg/m3/4W- intermittentLung, Thorax, or Respiration: Fibrosis (interstitial)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0539172

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWHUTOX* -,259,1996
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWTXAPA9 243,225,2010
TOXICOLOGY REVIEWFCTOD7 84,S1,2015
TOXICOLOGY REVIEWFCTOD7 97,S180,2016

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,297,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 10210; Number of Industries 85; Total Number of Facilities 9179; Number of Occupations 81; Total Number of Employees Exposed 155176; Total Number of Female Employees Exposed 55139
National Occupational Hazard Survey 1974Hazard Code 10210; Number of Industries 35; Total Number of Facilities 2798; Number of Occupations 52; Total Number of Employees Exposed 77830

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
Page last reviewed: November 16, 2018