Benzene, 1,2-(methylenedioxy)-4-propenyl-

RTECS #
DA5950000
CAS #
120-58-1
See: NMAM or OSHA Methods
Updated
June 2017
Molecular Weight
162.20
Molecular Formula
C10H10O2
Synonyms
1,2-Methylenedioxy-4-propenylbenzene
1,3-Benzodioxole, 5-(1-propenyl)-
3,4-Methylenedioxy-1-propenyl benzene
4-Propenyl-1,2-methylenedioxybenzene
4-Propenylcatechol methylene ether
5-(1-Propenyl)-1,3-benzodioxole
Isosafrole
RCRA waste number U141

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg/24H moderateFCTXAV 14,329,1976

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 61 gm/kg/81W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
JNCIAM 42,1101,1969
oral/mouse toxic dose: 101 gm/kg/81W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
FCTXAV 19,130,1981

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 324 mg/kgYKKZAJ 104,793,1984
intraperitoneal/rat lowest published toxic dose: 162 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOXID9 60,236,2001
intravenous/rabbit lowest published lethal dose: 300 mg/kgAEXPBL 35,342,1895
multiple/man lowest published toxic dose: 47 mg/kg/1W- intermittentBehavioral: Hallucinations, distorted perceptions

Behavioral: Toxic psychosis
AJPSAO 141,997,1984
oral/mouse lethal dose (50 percent kill): 2470 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
FCTXAV 2,327,1964
oral/rat lethal dose (50 percent kill): 1340 mg/kgTXAPA9 7,18,1965
subcutaneous/mouse lethal dose (50 percent kill): 1030 mg/kgBehavioral: Convulsions or effect on seizure thresholdSIZSAR 3,73,1952

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/chicken lowest published toxic dose: 450 mg/kg/3D- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
CBCPAI 130,67,2001
intraperitoneal/rat lowest published toxic dose: 450 mg/kg/3D- intermittentLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other proteins
HETOEA 11,580,1992
intraperitoneal/rat lowest published toxic dose: 600 mg/kg/4D- intermittentEndocrine: Evidence of thyroid hypofunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
TXAPA9 111,99,1991
intraperitoneal/rat lowest published toxic dose: 600 mg/kg/4D- intermittentEndocrine: Evidence of thyroid hypofunctionTXAPA9 111,99,1991
intraperitoneal/wild bird lowest published toxic dose: 450 mg/kg/3D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Metabolism (intermediary): Other proteins
CBCPAI 130,67,2001
oral/rat lowest published toxic dose: 453.6 mg/kg/14D- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 243,300,2010
oral/rat lowest published toxic dose: 2916 mg/kg/90D- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 243,300,2010
oral/rat lowest published toxic dose: 26250 mg/kg/15W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTXAPA9 7,18,1965
unreported route/rat lowest published toxic dose: 29196 mg/kg/90D- intermittentLiver: Other changesTOXID9 -,228,2009

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 10,231,1976
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 10,231,1976
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWMUTAEX 22,161,2007
TOXICOLOGY REVIEWFCTOD7 92,150,2016

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Page last reviewed: November 16, 2018