Benzeneacetic acid, 4-chloro-alpha-(1-methylethyl)-, cyano(3-phenoxyphenyl)methyl ester
RTECS #
CY1576350
CAS #
Updated
March 2019
Molecular Weight
419.93
Molecular Formula
C25H22ClNO3
Synonyms
(RS)-alpha-Cyano-3-phenoxybenzyl (RS)-2-(4-chlorophenyl)-3-methylbutyrate
Agrofen
alpha-Cyano-3-phenoxybenzyl 2-(4-chlorophenyl)isovalerate
alpha-Cyano-3-phenoxybenzyl-2-(4-chlorophenyl)-3-methylbutyrate
Aqmatrine
Belmark
Cyano(3-phenoxyphenyl)methyl 4-chloro-alpha-(1-methylethyl)benzeneacetate
Ectrin
Evercide 2362
Fenkem
Fenkill
Fenval
Fenvalerate
Furitrothion
Gold crest tribute
Insectral
OMS-2000
Phenvalerate
Pydrin
S 5602
Sanmarton
SD 43775
Sumibac
Sumicidin
Sumicidin 20E
Sumifleece
Sumifly
Sumipower
Sumitick
Tribute
WL 43775
Agrofen
alpha-Cyano-3-phenoxybenzyl 2-(4-chlorophenyl)isovalerate
alpha-Cyano-3-phenoxybenzyl-2-(4-chlorophenyl)-3-methylbutyrate
Aqmatrine
Belmark
Cyano(3-phenoxyphenyl)methyl 4-chloro-alpha-(1-methylethyl)benzeneacetate
Ectrin
Evercide 2362
Fenkem
Fenkill
Fenval
Fenvalerate
Furitrothion
Gold crest tribute
Insectral
OMS-2000
Phenvalerate
Pydrin
S 5602
Sanmarton
SD 43775
Sumibac
Sumicidin
Sumicidin 20E
Sumifleece
Sumifly
Sumipower
Sumitick
Tribute
WL 43775
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | lymphocyte/human | 2 mg/L | MUTAEX 4,72,1989 |
| Cytogenetic Analysis | oral/rat | 1050 mg/kg/3W-continuous | MUREAV 105,101,1982 |
| Cytogenetic Analysis | intraperitoneal/mouse | 200 mg/kg | MUREAV 222,149,1989 |
| Cytogenetic Analysis | oral/mouse | 200 mg/kg | MUREAV 222,149,1989 |
| Cytogenetic Analysis | subcutaneous/mouse | 200 mg/kg | MUREAV 222,149,1989 |
| Cytogenetic Analysis | intraperitoneal/mouse | 20 mg/kg/5D | MUREAV 520,125,2002 |
| Cytogenetic Analysis | inhalation/hamster | 23.8 µmol/L | MUREAV 608,28,2006 |
| Cytogenetic Analysis | /hamster | 23.8 µmol/L | MUREAV 608,28,2006 |
| micronucleus test | unreported route/mouse | 10 mg/kg | CHYCDW 20,238,1986 |
| micronucleus test | intraperitoneal/mouse | 300 mg/kg/24H- intermittent | MUREAV 222,149,1989 |
| morphological transform | oral/rat | 3750 mg/kg/10W- intermittent | ARTODN 61,218,1988 |
| other mutation test systems | liver/rabbit | 2 mg/L | JPFCD2 23,439,1988 |
| other mutation test systems | other cell types/rabbit | 200 µg/L | JPFCD2 23,439,1988 |
| sister chromatid exchange | intraperitoneal/mouse | 5 mg/kg | MUREAV 520,125,2002 |
| sister chromatid exchange | lymphocyte/human | 10 mg/L | MUTAEX 4,72,1989 |
| sperm morphology | unreported route/mouse | 20 mg/kg | CHYCDW 20,238,1986 |
| sperm morphology | parenteral/mouse | 100 mg/kg | MUREAV 222,149,1989 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/rat | 60 mg/kg (18D preg/1-5D after birth) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Physical | NETEEC 21,611,1999 |
| intraperitoneal/rat | 60 mg/kg (18D preg/5D after birth) | Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Delayed effects | NETEEC 27,609,2005 |
| oral/mouse | 1320 mg/kg (22D after birth) | Reproductive: Effects on newborn: Delayed effects Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Germ cell effects (in offspring) | TOLED5 191,47,2009 |
| oral/mouse | 180 mg/kg (13-18D pregnant) | Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Physical | FCTOD7 48,1160,2010 |
| parenteral/mouse | 100 mg/kg (5D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | MUREAV 222,149,1989 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, kidney | Inhibitor Concentration (20 percent kill): >100 µmol/L/2H | In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc. | TIVIEQ 40,66,2017 |
| In Vitro/Human, kidney | Inhibitor Concentration (20 percent kill): >100 µmol/L/2H | Endocrine: Other changes | TIVIEQ 40,66,2017 |
| In Vitro/jpc | Inhibitor Concentration Low: 100 mg/L/24H | In Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc. | TXCYAC 285,126,2011 |
| In Vitro/jpc | Inhibitor Concentration Low: 1000 mg/L/24H | In Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc. In Vitro Toxicity Studies: Apoptosis in vitro | TXCYAC 285,126,2011 |
| In Vitro/jrd | Inhibitor Concentration Low: >25 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOLED5 226,132,2014 |
| In Vitro/mti | Inhibitor Concentration Low: 1 µmol/L/24H | In Vitro Toxicity Studies: Other assays | TXCYAC 292,151,2012 |
| In Vitro/Rat, neurons | Inhibitor Concentration Low: 40 µmol/L/1H | In Vitro Toxicity Studies: Other assays | NRTXDN 44,204,2014 |
| inhalation/rat | lethal concentration (50 percent kill): >2.9 gm/m3 | ENTOX* -,328,2005 | |
| intracerebral/mouse | lowest published lethal dose: 200 µg/kg | TXAPA9 66,290,1982 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): >500 mg/kg | JAFCAU 26,954,1978 | |
| intraspinal/mouse | lowest published toxic dose: 4 µg/kg | Peripheral Nerve and Sensation: Sensory change involving peripheral nerve | EJPHAZ 534,123,2006 |
| intravenous/rat | lowest published lethal dose: 50 mg/kg | Behavioral: Tremor Behavioral: Change in motor activity (specific assay) Behavioral: Muscle contraction or spasticity | ARTODN 45,325,1980 |
| oral/chicken | lowest published lethal dose: 2400 mg/kg | Behavioral: Somnolence (general depressed activity) Gastrointestinal: Hypermotility, diarrhea Gastrointestinal: Other changes | IVEJAC 58,941,1981 |
| oral/chicken | lethal dose (50 percent kill): >1 gm/kg | ENTOX* -,328,2005 | |
| oral/Dog | lethal dose (50 percent kill): >1 gm/kg | SPEADM 78-1,6,1978 | |
| oral/domestic animal | lethal dose (50 percent kill): >1600 mg/kg | 85JFAN A207,1984 | |
| oral/mouse | lethal dose (50 percent kill): 185 mg/kg | Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia | FAATDF 5,278,1985 |
| oral/quail | lethal dose (50 percent kill): >4 gm/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Muscle weakness Behavioral: Muscle contraction or spasticity | JTEHD6 10,307,1982 |
| oral/rat | lethal dose (50 percent kill): >400 mg/kg | ENTOX* -,328,2005 | |
| oral/rat | lowest published toxic dose: 389 mg/kg | Blood: Changes in erythrocyte (RBC) count Blood: Changes in leukocyte (WBC) count | BECTA6 70,839,2003 |
| oral/rat | lowest published lethal dose: 1949 mg/kg | BECTA6 70,839,2003 | |
| oral/rat | lethal dose (50 percent kill): 70200 µg/kg | Eye: Lacrimation Behavioral: Excitement Behavioral: Ataxia | CHYCDW 21,215,1987 |
| oral/wild bird | lethal dose (50 percent kill): >1 gm/kg | ENTOX* -,328,2005 | |
| skin/rabbit | lethal dose (50 percent kill): >2 gm/kg | ENTOX* -,328,2005 | |
| skin/rat | lethal dose (50 percent kill): >5 gm/kg | PEMNDP 9,388,1991 | |
| unreported route/mammal (species unspecified) | lethal dose (50 percent kill): 451 mg/kg | Brain and Coverings: Recordings from specific areas of CNS | GISAAA 53(4),70,1988 |
| unreported route/rat | lethal dose (50 percent kill): 202 mg/kg | IJEBA6 29,176,1991 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 290 µg/m3/24H/13W- continuous | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases | GISAAA 53(4),70,1988 |
| intraperitoneal/rat | lowest published toxic dose: 700 mg/kg/7D- intermittent | Behavioral: Tremor | TOLED5 89,29,1996 |
| intraperitoneal/rat | lowest published toxic dose: 2400 mg/kg/12D- intermittent | Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia | TOLED5 89,29,1996 |
| intraperitoneal/rat | lowest published toxic dose: 1700 mg/kg/17D- intermittent | Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia | TOLED5 89,29,1996 |
| intraperitoneal/rat | lowest published toxic dose: 1500 mg/kg/15D- intermittent | Endocrine: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | TOLED5 89,29,1996 |
| intraperitoneal/rat | lowest published toxic dose: 4500 mg/kg/45D- intermittent | Brain and Coverings: Other degenerative changes | TOLED5 89,29,1996 |
| oral/chicken | lowest published toxic dose: 196 mg/kg/8W- continuous | Musculoskeletal: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation | TOPADD 32,364,2004 |
| oral/chicken | lowest published toxic dose: 14717 mg/kg/28D- intermittent | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | IJEBA6 32,752,1994 |
| oral/Dog | lowest published toxic dose: 4550 mg/kg/26W- intermittent | Blood: Changes in cell count (unspecified) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | FAATDF 4,577,1981 |
| oral/mouse | lowest published toxic dose: 870 mg/kg/29D- intermittent | Brain and Coverings: Other degenerative changes Endocrine: Other changes | TOLED5 201,181,2011 |
| oral/mouse | lowest published toxic dose: 217.5 mg/kg/29D- intermittent | Brain and Coverings: Other degenerative changes Endocrine: Androgenic | TOLED5 201,181,2011 |
| oral/mouse | lowest published toxic dose: 870 mg/kg/29D- intermittent | Brain and Coverings: Other degenerative changes Endocrine: Estrogenic | TOLED5 201,181,2011 |
| oral/mouse | lowest published toxic dose: 810 mg/kg/27D- intermittent | Behavioral: Change in motor activity (specific assay) Behavioral: Antianxiety Behavioral: Change in psychophysiological tests | TOLED5 203,245,2011 |
| oral/mouse | lowest published toxic dose: 202.5 mg/kg/27D- intermittent | Behavioral: Alteration of operant conditioning | TOLED5 203,245,2011 |
| oral/mouse | lowest published toxic dose: 810 mg/kg/27D- intermittent | Behavioral: Change in motor activity (specific assay) Behavioral: Alteration of operant conditioning Behavioral: Change in psychophysiological tests | TOLED5 203,245,2011 |
| oral/mouse | lowest published toxic dose: 109 gm/kg/2Y- continuous | Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | FAATDF 3,114,1983 |
| oral/quail | lowest published toxic dose: 180 gm/kg/5D- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JTEHD6 10,307,1982 |
| oral/quail | lowest published toxic dose: 1152 mg/kg/7D- continuous | Gastrointestinal: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | BECTA6 31,479,1983 |
| oral/rat | lowest published toxic dose: 36400 mg/kg/2Y- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTEHD6 13,83,1984 |
| oral/rat | lowest published toxic dose: 2002 mg/kg/13W- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TOXID9 8,175,1988 |
| oral/rat | lowest published toxic dose: 129.5 mg/kg/7D- intermittent | Blood: Changes in erythrocyte (RBC) count Blood: Changes in leukocyte (WBC) count | BECTA6 70,839,2003 |
| oral/rat | lowest published toxic dose: 388.5 mg/kg/21D- intermittent | Blood: Macrocytosis Blood: Changes in leukocyte (WBC) count | BECTA6 70,839,2003 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMEMDT 53,309,1991 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human No Available Data | IMEMDT 53,309,1991 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMEMDT 53,309,1991 |
| TOXICOLOGY REVIEW | JTCTDW 38,103,2000 | |
| TOXICOLOGY REVIEW | MUTAEX 21,93,2006 | |
| TOXICOLOGY REVIEW | ENTOX* -,328,2005 | |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
| TOXICOLOGY REVIEW | JTPAE7 19,1,2006 | |
| TOXICOLOGY REVIEW | HUTOX* -,541,1996 | |
| TOXICOLOGY REVIEW | MUREAV 681,3,2009 | |
| TOXICOLOGY REVIEW | MUREAV 681,93,2009 | |
| TOXICOLOGY REVIEW | FEREAC 73,80317,2008 | |
| TOXICOLOGY REVIEW | FEREAC 74,46689,2009 | |
| TOXICOLOGY REVIEW | TXCYAC 267,1,2010 | |
| TOXICOLOGY REVIEW | MUREAV 721,27,2011 | |
| TOXICOLOGY REVIEW | TXAPA9 258,309,2012 | |
| TOXICOLOGY REVIEW | NRTXDN 33,1473,2012 | |
| TOXICOLOGY REVIEW | TXCYAC 307,66,2013 | |
| TOXICOLOGY REVIEW | TOLED5 230,85,2014 | |
| TOXICOLOGY REVIEW | TXAPA9 268,157,2013 | |
| TOXICOLOGY REVIEW | MUREAV 802,1,2016 | |
| TOXICOLOGY REVIEW | MUTAEX 32,491,2017 | |
| TOXICOLOGY REVIEW | TIVIEQ 34,321,2016 | |
| TOXICOLOGY REVIEW | FCTOD7 108,365,2017 | |
| TOXICOLOGY REVIEW | VETODR ,197,2018 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Supported | RBREV* -,182,1998 |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 0.3 mg/m3, Skin, JUN2003 |
NIOSH Documentation and Surveillance
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| On EPA IRIS database |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health