CDC Articles and Key Findings from SET-NET Data

Below are key findings from reports that use SET-NET data.

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Key Findings

Pregnancy and Infant Outcomes by Trimester of SARS-CoV-2 Infection in Pregnancy – SET-NET, 22 Jurisdictions, January 25, 2020 - December 31, 2020 (Preprint)

An analysis of more than 35,000 people with COVID-19 during pregnancy in 2020 showed a higher rate of preterm delivery (14% of deliveries were preterm) among people with COVID-19 during pregnancy than the baseline rate of preterm delivery in the United States (10.2% of deliveries were preterm in 2019). In addition, there was a higher rate of preterm delivery among people who were infected during the third trimester (17.8% of deliveries were preterm) compared to people who were infected during their first or second trimesters (11.8% of deliveries were preterm). These findings emphasize the importance of COVID-19 vaccination for people who are pregnant or may become pregnant to protect both the mother and the infant.

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Breastmilk feeding of infants at birth among people with confirmed SARS-CoV-2 infection in pregnancy — SET-NET, Five States, March 29, 2020–December 31, 2020 (Preprint)

Data reported from five states on breastmilk feeding among people who had COVID-19 during pregnancy in 2020 found that 86% of people reported feeding breastmilk to their infants at delivery. However, people who had COVID-19 14 days or less before delivery and who did not room-in with their newborn after delivery were less likely to feed their infants breastmilk during their delivery hospitalization and may benefit from additional lactation support.

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Preterm Birth among Pregnant Persons with Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Data collected on 6,336 deliveries among people with COVID-19 during pregnancy from January 20-December 31, 2020 in 21 U.S. state, local, or territorial health departments showed that people who became critically ill with COVID-19 during their second or third trimester of pregnancy were four times more likely to have a preterm delivery (before 37 weeks of pregnancy) compared with people who had mild illness at these same points in pregnancy. Indications of critical illness included intensive care unit (ICU) admission, mechanical ventilation, and other complications.

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SARS-CoV-2 infections among neonates born to women with SARS-CoV-2 infection: maternal, pregnancy and birth characteristics

Among 28,771infants born to women with SARS-CoV-2 infection during pregnancy, 3,790(13%) had a positive or negative test result for COVID-19. Of these infants, 138 (3%) had a positive test result. infection was more frequent among infants born to mothers diagnosed with COVID-19 close to delivery (within 14 days of delivery) and among infants born preterm or admitted to the neonatal intensive care unit (NICU).

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Recurrent SARS-CoV-2 RNA Detection after COVID-19 Illness Onset during Pregnancy

Of 6,551 people with laboratory-confirmed and symptomatic COVID-19 during pregnancy included in this analysis, 142 (2.2%) had positive reverse transcription polymerase chain reaction (RT-PCR) test results after more than 90 days and up to 416 days after symptom onset. Data came from 21 U.S. jurisdictions and included people with a first positive RT-PCR test result during pregnancy occurring between March – December 2020, with data reported to CDC up to September 2021.

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Birth and Infant Outcomes Following Laboratory-Confirmed SARS-CoV-2 Infection in Pregnancy — SET-NET, 16 Jurisdictions, March 29–October 14, 2020

With data on nearly 4,000 infants born to women with laboratory-confirmed COVID-19, scientists found a higher percentage of preterm infants than seen nationally in 2019, suggesting that women with COVID-19 in pregnancy might be at risk for having a preterm infant.

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Risk factors for illness severity among pregnant women with confirmed SARS-CoV-2 infection – Surveillance for Emerging Threats to Mothers and Babies Network, 22 state, local, and territorial health departments, March 29, 2020–March 5, 2021

In an analysis of 7,950 pregnant women with COVID-19, scientists found that pregnant women who were older than 25 years of age, were employed as healthcare workers, and had underlying medical conditions were at increased risk of developing more severe COVID-19 illness compared with pregnant women without these characteristics. Risk for severe COVID-19 illness increased along with the number of underlying conditions a pregnant woman had.

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