Rare Factor Deficiencies

Table 4. HTC Population Profile Patient Characteristics, Rare Factor Deficiencies (excluding Factor VIII and Factor IX), Data Reported from 1/1/2012 through 9/29/2021

HTC Population Profile Patient Characteristics, Rare Factor Deficiencies (excluding Factor VIII and Factor IX)
FI FII FV Factors
V & VIII,
combined
FVII FX FXI FXIII Alpha-2
Antiplasmin
Deficiency
PAI-1
Deficiency
# (%) # (%) # (%) # (%) # (%) # (%) # (%) # (%) # (%) # (%)
# of patients 404 (100) 123 (100) 571 (100) 22 (100) 2654 (100) 284 (100) 1580 (100) 255 (100) 13 (100) 345 (100)
Age (years) <2 28 (7) * * 16 (3) * * 48 (2) * * 64 (4) 15 (6) * * 10 (3)
2-10 104 (26) 20 (16) 71 (12) * * 665 (25) 62 (22) 223 (14) 45 (18) * * 50 (14)
11-19 108 (27) 50 (41) 194 (34) 6 (27) 1110 (42) 83 (29) 410 (26) 48 (19) * * 131 (38)
20-44 102 (25) 31 (25) 185 (32) 7 (32) 586 (22) 73 (26) 459 (29) 106 (42) * * 100 (29)
45-64 42 (10) 14 (11) 75 (13) * * 151 (6) 44 (15) 221 (14) 25 (10) * * 33 (10)
65+ 20 (5) * * 30 (5) * * 94 (4) * * 203 (13) 16 (6) * * 21 (6)
Sex Male 175 (43) 45 (37) 218 (38) 11 (50) 1297 (49) 119 (42) 708 (45) 124 (49) * * 107 (31)
Female 229 (57) 78 (63) 353 (62) 11 (50) 1357 (51) 165 (58) 872 (55) 131 (51) * * 238 (69)
Ethnicity Hispanic, Latino/a, or Spanish origin 45 (11) * * 87 (15) * * 580 (22) 61 (21) 191 (12) * * * * * *
Not Hispanic, Latino/a, or Spanish origin 340 (84) 82 (67) 463 (81) 22 (100) 1947 (73) 207 (73) 1336 (85) 196 (77) * * 273 (79)
Unknown 19 (5) * * 21 (4) * * 127 (5) 16 (6) 53 (3) * * * * * *
Race American Indian/Alaska Native * * * * * * * * * * * * * * * * * * * *
Asian 18 (4) * * 15 (3) * * 82 (3) 20 (7) 56 (4) 26 (10) * * * *
Black or African American 21 (5) * * 19 (3) * * 481 (18) 32 (11) 71 (4) 25 (10) * * 34 (10)
Native Hawaiian or other Pacific Islander * * * * * * * * * * * * * * * * * * * *
White 321 (79) 101 (82) 487 (85) 15 (68) 1788 (67) 202 (71) 1342 (85) 179 (70) * * 281 (81)
More than one of these * * * * * * * * 47 (2) * * 11 (1) * * * * 6 (2)
Unknown 37 (9) 12 (10) 41 (7) * * 235 (9) * * 94 (6) * * * * 16 (5)
Insurance Status Insured 389 (96) 116 (94) 559 (98) 20 (91) 2585 (97) 276 (97) 1544 (98) 247 (97) * * 327 (95)
Uninsured * * * * * * * * 29 (1) * * 13 (1) * * * * * *
Unknown * * * * * * * * 40 (2) * * 23 (1) * * * * * *
History of HCV infection Yes 11 (3) 7 (6) 11 (2) * * 27 (1) 9 (3) 32 (2) 10 (4) * * * *
No 279 (69) 67 (54) 411 (72) 15 (68) 1991 (75) 206 (73) 1177 (74) 208 (82) * * 195 (57)
Unknown 114 (28) 49 (40) 149 (26) * * 636 (24) 69 (24) 371 (23) 37 (15) * * * *
History of HIV infection Yes * * * * * * * * * * * * 9 (1) * * * * * *
No 289 (72) 74 (60) 418 (73) 15 (68) 2014 (76) 216 (76) 1206 (76) 220 (86) * * 195 (57)
Unknown * * * * * * * * * * * * 365 (23) * * * * * *

Note. This table excludes individuals with Factor VIII deficiency (hemophilia A) and Factor IX deficiency (hemophilia B). “Factors V & VIII, combined” refers to an autosomal condition, which occurs when there is a defect in a gene on one of the first 22 pairs of chromosomes called autosomes. Hemophilia A and B are X-linked conditions, which occur when there is a defect on the 23rd pair of chromosomes which determine one’s sex.

On August 10, 2020, “intersex” was added as a response option. The number of intersex patients is too small to report by year or other characteristics; therefore, these counts have been excluded to protect patient confidentiality.

* Counts of five or fewer have been suppressed to protect patient confidentiality. Additional cells may be suppressed to prevent derivation of these counts by subtraction.