FAQs: References on Folic Acid Information

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FAQ Topic Areas
  1. General Information About NTDs, Folic Acid, and Folate
  2. Folic Acid Safety, Interactions, and Effects on Other Outcomes
  3. Folic Acid and Its Link to Other Health Outcomes
  4. Folic Acid Fortification and Supplementation
  5. Neural Tube Defects Surveillance
  6. References
Related Pages
  1. Crider KS, Bailey LB, Berry RJ. Folic acid food fortification-its history, effect, concerns, and future directions. Nutrients 2011;3(3):370-84. doi: 10.3390/nu3030370.
  2. De Wals P, Tairou F, Van Allen MI, Uh SH, Lowry RB, Sibbald B, Evans JA, Van den Hof MC, Zimmer P, Crowley M, et al. Reduction in neural-tube defects after folic acid fortification in Canada. N Engl J Med 2007;357(2):135-42. doi: 10.1056/NEJMoa067103.
  3. De Wals P, Tairou F, Van Allen MI, Lowry RB, Evans JA, Van den Hof MC, Crowley M, Uh SH, Zimmer P, Sibbald B, et al. Spina bifida before and after folic acid fortification in Canada. Birth Defects Res A Clin Mol Teratol 2008;82(9):622-6. doi: 10.1002/bdra.20485.
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  6. Prevention of Neural Tube Defects: Results of the Medical Research Council Vitamin Study. Lancet, 1991:131-7.
  7. Tinker SC, Cogswell ME, Hamner HC, Berry RJ. Usual folic acid intakes: a modelling exercise assessing changes in the amount of folic acid in foods and supplements, National Health and Nutrition Examination Survey, 2003-2008. Public health nutrition 2012;15(7):1216-27. doi: 10.1017/S1368980012000638.
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  9. Crider KS, Zhu JH, Hao L, Yang QH, Yang TP, Gindler J, Maneval DR, Quinlivan EP, Li Z, Bailey LB, et al. MTHFR 677C->T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation. Am J Clin Nutr 2011;93(6):1365-72. doi: 10.3945/ajcn.110.004671.
  10. Shelnutt KP, Kauwell GP, Gregory JF, 3rd, Maneval DR, Quinlivan EP, Theriaque DW, Henderson GN, Bailey LB. Methylenetetrahydrofolate reductase 677C–>T polymorphism affects DNA methylation in response to controlled folate intake in young women. J Nutr Biochem 2004;15(9):554-60.
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Page last reviewed: June 17, 2022
Content source:  National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Centers for Disease Control and Prevention