CDC’s Articles on the Global Prevention of Neural Tube Defects

Key Findings

Key Findings: Global Burden of Neural Tube Defects
The journal PLOS ONE published a study describing the burden of neural tube defects in many countries, as well as the gaps in available data on neural tube defects worldwide.
(Published: April 2016)

Key Findings: Assessing the Association between Natural Food Folate Intake and Blood Folate Concentrations
The journal Nutrients published a study that assessed, across different populations, the relationship between the amount of natural food folate consumed by women and their blood folate concentrations.
(Published: April 2015)

Key Findings: Population Red Blood Cell Folate Concentrations for the Prevention of Neural Tube Defects
The British Medical Journal published a study that describes the relationship between women’s blood folate concentrations and the risk of having a baby affected by a neural tube defect.
(Published: July 2014)

Feature Articles

World Birth Defects Day
March 3rd is World Birth Defects Day, which aims to raise awareness of birth defects, their causes, and their impact around the world. Every year, about 3–6% of infants worldwide are born with a serious birth defect. This means that life-altering conditions like spina bifida and congenital heart defects affect millions of babies and families.
(Published: February 2019)

The Importance of Folic Acid
Read Anifa’s story and find out what CDC is doing to help.
(Published: December 2017)

Publications of Interest

Defining the plasma folate concentration associated with the red blood cell folate concentration threshold for
optimal neural tube defects prevention: a population-based, randomized trial of folic acid supplementation
Am J Clin Nutr. May 2019.
Chen MY, Rose CE, Qi YP, Williams JL, Yeung LF, Berry RJ, Hao L, Cannon MJ, Crider KS.
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Global folate status in women of reproductive age: A systematic review with emphasis on methodological issues
Ann N Y Acad Sci. September 2018;1431(1):35−57.
Rogers LM, Cordero AM, Pfeiffer CM, Hausman DB, Tsang BL, De-Regil LM, Rosenthal, J, Razzaghi H, Wong EC, Weakland AP, Bailey, LB.
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Development and utility of a birth defects surveillance toolkit
J Glob Health Perspect. June 2018.
Flores AL, Turay K, Valencia D, Hillard CL, Sekkarie A, Zaganjor I, Williams J, Qi YP, Cordero AM, Mulinare J, Botto LD, Peña-Rosas JP, Groisman B, Mastroiacovo P.
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Folate deficiency is prevalent in women of childbearing age in Belize and is negatively affected by coexisting vitamin B-12 deficiency: Belize National Micronutrient Survey 2011
J Nutr. June 2017;147(6):1183−1193.
Rosenthal J, Largaespada N, Bailey LB, Cannon M, Alverson CJ, Ortiz D, Kauwell G, Sniezek J, Figueroa R, Daly R, Allen P.
[Read articleexternal icon][

Trends and characteristics of fetal and neonatal mortality due to congenital anomalies, Colombia, 1999-2009
J Matern Fetal Neonatal Med. May 2017;31(13):1748−1755.
Roncancio CP, Misnaza SP, Peña IC, Prieto FE, Cannon MJ, Valencia D.
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Red blood cell folate insufficiency among nonpregnant women of childbearing age in Guatemala 2009 to 2010:
prevalence and predicted neural tube defects risk
Birth Defects Res A Clin Mol Teratol. July 2016;106(7):587−595.
Rosenthal J, Reeve ME, Ramirez N, Crider KS, Sniezek J, Vellozzi C, Devine O, Lopez-Pazos E
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Describing the prevalence of neural tube defects worldwide: A systematic literature review
PLoS One. April 2016;11(4):e0151586.
Zaganjor I, Sekkarie A, Tsang BL, Williams J, Razzaghi H, Mulinare J, Sniezek JE, Cannon MJ, Rosenthal J.
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Building capacity for birth defects surveillance in Africa: Implementation of an intermediate birth defects surveillance workshop
J Glob Health Perspect. December 2015;2015.
Flores A, Valencia D, Sekkarie A, Hillard CL, Williams J, Groisman B, Botto LD, Peña-Rosas JP, Bauwens L, Mastroiacovo P.
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Assessing the association between natural food folate intake and blood folate concentrations: a systematic
review and Bayesian meta-analysis of trials and observational studies
Nutrients. April 2015;7(4):2663−2686.
Marchetta CM, Devine OJ, Crider KS, Tsang BL, Cordero AM, Qi YP, Guo J, Berry RJ, Rosenthal J, Mulinare J,
Mersereau P, Hamner HC.
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Optimal serum and red blood cell folate concentrations in women of reproductive age for prevention of neural tube defects: World Health Organization guidelines
MMWR Morb Mortal Wkly Rep. April 2015;64(15):421−423.
Cordero AM, Crider KS, Rogers LM, Cannon MJ, Berry RJ.
[Read article]

Neural tube defects in Latin America and the impact of fortification: A literature review
Public Health Nutr. March 2014;17(3):537−550.
Rosenthal J, Casas J, Taren D, Alverson CJ, Flores A, Frias J.
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