Folic Acid & Neural Tube Defects: Articles & Key Findings

Key Findings

Key Findings: Global Burden of Neural Tube Defects
The journal, PLOS ONE, has published a study describing the burden of neural tube defects in many countries and gaps in available data on neural tube defects worldwide.
(Published June 17, 2016)

Key Findings: Assessing the Association between Natural Food Folate Intake and Blood Folate Concentrations
The journal Nutrients has published a new study that assessed the relationship between the amount of natural food folate consumed by women and their blood folate concentrations.
(Published April, 2015)

Key Findings: Blood Folate Concentrations and Risk of Neural Tube Defect-Affected Pregnancies: Where Does the United States Stand?
Birth Defects Research Part A has published a new study that looked at the amount of folate in the blood (“blood folate concentrations”) among women in the United States in relation to their risk of having a baby affected by a neural tube defect.
(Published April, 2015)

Key Findings: Population Red Blood Cell Folate Concentrations for the Prevention of Neural Tube Defects
This study describes the relationship between women’s blood folate concentrations and the risk of having a baby affected by a neural tube defect.
(Published July, 2014)

Key Findings: Fortification of Corn Masa Flour With Folic Acid in the United States
Article about the fortification of corn masa flour with folic acid in the United States and how it can improve health outcomes for Hispanics.
(Published May, 2014)

Flores A, Valencia D, Sekkarie A, Hillard CL, Williams J, Groisman B, Botto LD, Peña-Rosas JP, Bauwens L, Mastroiacovo P. Building capacity for birth defects surveillance in Africa: Implementation of an intermediate birth defects surveillance workshopExternal. Journal of Global Health Perspectives. 2015 Dec 19 [last modified: 2015 Dec 19]. Edition 1.

CDC. Updated Estimates of Neural Tube Defects Prevented by Mandatory Folic Acid Fortification — United States, 1995–2011. MMWR Morb Mort Wkly Rep. 2015: 64(01); 1-5.

Tinker SC, Hamner HC, Qi YP, Crider KS. U.S. Women of Childbearing Age Who Are at Possible Increased Risk of a Neural Tube Defect-Affected Pregnancy Due to Suboptimal Red Blood Cell Folate ConcentrationsExternal, National Health and Nutrition Examination Survey 2007 to 2012. Birth Defect Research Part A: 2015.

Cordero AM, Crider KS, Rogers LM, et al. Optimal Serum and Red Blood Cell Folate Concentrations in Women of Reproductive Age for Prevention of Neural Tube Defects: World Health Organization Guidelines. MMWR Morb Mortal Wkly Rep 2015; 64:421-423.

Marchetta CM, Devine OJ, Crider KS, Tsang BL, Cordero AM, Qi YP, Guo J, Berry RJ, Rosenthal J, Mulinare J, Mersereau P, Hamner HC. Assessing the Association between Natural Food Folate Intake and Blood Folate Concentrations: A Systematic Review and Bayesian Meta-Analysis of Trials and Observational StudiesExternal. Nutrients: 2015.

Tinker, S. C., Devine, O., Mai, C., Hamner, H. C., Reefhuis, J., Gilboa, S. M., Dowling, N. F. and Honein, M. A. (2013), Estimate of the potential impact of folic acid fortification of corn masa flour on the prevention of neural tube defectsExternal. Birth Defects Research Part A: Clinical and Molecular Teratology, 97: 649–657. doi: 10.1002/bdra.23158.

Andrew E. Czeizel, M.D., D.Sc., and István Dudás, M.D. Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin SupplementationExternal. N Engl J Med 1992; 327:1832-1835December 24, 1992DOI: 10.1056/NEJM199212243272602.

MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin StudyExternal. Lancet. 1991 Jul 20;338(8760):131-7.