COVID-19 and Other Underlying Causes of Cancer Deaths — United States, January 2018–July 2022

Cancer survivors (persons who have received a diagnosis of cancer, from the time of diagnosis throughout their lifespan)* have increased risk for severe COVID-19 illness and mortality (1). This report describes characteristics of deaths reported to CDC's National Vital Statistics System (NVSS), for which cancer was listed as the underlying or a contributing cause (cancer deaths) during January 1, 2018-July 2, 2022. The underlying causes of death, including cancer and COVID-19, were examined by week, age, sex, race and ethnicity, and cancer type. Among an average of approximately 13,000 weekly cancer deaths, the percentage with cancer as the underlying cause was 90% in 2018 and 2019, 88% in 2020, and 87% in 2021. The percentage of cancer deaths with COVID-19 as the underlying cause differed by time (2.0% overall in 2020 and 2.4% in 2021, ranging from 0.2% to 7.2% by week), with higher percentages during peaks in the COVID-19 pandemic. The percentage of cancer deaths with COVID-19 as the underlying cause also differed by the characteristics examined, with higher percentages observed in 2021 among persons aged ≥65 years (2.4% among persons aged 65-74 years, 2.6% among persons aged 75-84 years, and 2.4% among persons aged ≥85 years); males (2.6%); persons categorized as non-Hispanic American Indian or Alaska Native (AI/AN) (3.4%), Hispanic or Latino (Hispanic) (3.2%), or non-Hispanic Black or African American (Black) (2.5%); and persons with hematologic cancers, including leukemia (7.4%), lymphoma (7.3%), and myeloma (5.8%). This report found differences by age, sex, race and ethnicity, and cancer type in the percentage of cancer deaths with COVID-19 as the underlying cause. These results might guide multicomponent COVID-19 prevention interventions and ongoing, cross-cutting efforts to reduce health disparities and address structural and social determinants of health among cancer survivors, which might help protect those at disproportionate and increased risk for death from COVID-19.

International Classification of Diseases, Tenth Revision (ICD-10) (2). A single underlying cause of death is listed on the death certificate as the disease or injury initiating the chain of morbid events leading directly to death. Other diseases or conditions might be listed as contributing causes of death if they increased susceptibility to or exacerbated an existing disease or contributed to death in some way but did not initiate the chain of events leading to death. § Cancer deaths were defined as those with malignant neoplasm (ICD-10 codes C00-C97) listed as either the underlying or a contributing cause of death. The weekly numbers of cancer deaths, and their underlying causes, were tabulated. ¶ The percentages (and 95% Wilson CIs) of cancer deaths with cancer or COVID-19 as the underlying cause of death were examined by year, age, sex, race and ethnicity, and cancer type.** This activity was reviewed by CDC and was conducted consistent with applicable federal law and CDC policy. † † On average, approximately 13,000 deaths each week listed cancer as an underlying or contributing cause (range = 12,221-14,845) during January 7, 2018-July 2, 2022, with peaks occurring in January 2021 (14,284) and January 2022 (14,845) ( Figure 1) (Supplementary Table, https://stacks.cdc.gov/view/cdc/122581). Approximately 11,500 cancer deaths with cancer as the underlying cause occurred each week during this period, ranging from 10,891 in June 2020 to 12,408 in January 2018. From 2018 to 2021, the annual number of cancer deaths increased 4.7%, and the number with cancer as the underlying cause increased 1.0%. During 2020-2022, the weekly number of cancer deaths with COVID-19 as the underlying cause ranged from 28 to 1,055, peaking in January 2021 (953) and January 2022 (1,055). The weekly number of cancer deaths with COVID-19 as a § https://www.cdc.gov/nchs/nvss/revisions-of-the-us-standard-certificates-andreports.htm; https://www.cdc.gov/nchs/data/nvss/vsrg/vsrg03-508.pdf; https:// www.cdc.gov/nchs/pressroom/podcasts/2022/20220107/20220107.htm ¶ Underlying cause of death was coded as follows by using ICD-10: malignant neoplasms (cancer) (ICD-10 codes C00-C97); diseases of the circulatory system (I00-I99), including heart disease and stroke; mental and behavioral disorders and diseases of the nervous system (F00-G99), including Alzheimer disease; endocrine, nutritional, metabolic, and digestive system diseases (E00-E99 and K00-K99), including diabetes and cirrhosis; diseases of the respiratory system (J00-J99), including chronic obstructive pulmonary disease, influenza, and pneumonia; confirmed or presumed COVID-19 (U07. contributing cause ranged from 10 to 463 during 2020-2022 and was highest in January 2021 (242) and January 2022 (463). Among cancer deaths, the percentage with cancer as the underlying cause was 90% in 2018 and 2019 (weekly range = 89%-91%), 88% (83%-90%) in 2020, and 87% (83%-89%) in 2021 (Table); during the first half of 2022, this percentage ranged from 81% to 89%. Among deaths with cancer as a contributing cause, common noncancer underlying causes included diseases of the circulatory system, including heart disease and stroke; mental and behavioral disorders and diseases of the nervous system, including Alzheimer disease; endocrine, nutritional, metabolic, and digestive system diseases, including diabetes and cirrhosis; diseases of the respiratory system, including chronic obstructive pulmonary disease, influenza, and pneumonia; and COVID-19 ( Figure 2). During November 22, 2020-February 6, 2021, and January 9-February 19, 2022, the number of cancer deaths with COVID-19 as underlying cause exceeded the number for any other underlying cause, except cancer. The percentage of cancer deaths with COVID-19 as the underlying cause was 2.0% in 2020 (weekly range = 0.2%-6.4%) and 2.4% in 2021 (range = 0.4%-6.7%) (Table); during the first half of 2022, this percentage ranged from 1.0% to 7.2%.
The percentage of cancer deaths with COVID-19 as the underlying cause differed by demographic characteristics and type of malignancy. In 2021, a higher percentage of cancer deaths with COVID-19 as the underlying cause occurred among males (2.6%) than females (2.1%); persons aged ≥65 years (2.4% among persons aged 65-74 years, 2.6% among persons aged 75-84 years, and 2.4% among persons aged ≥85 years) than among those aged 15-64 years (ranging from 1.5% to 2.1% by age group); and AI/AN persons (3.4%), Hispanic persons (3.2%), and Black persons (2.5%) compared with a range from 1.5% to 2.3% among persons of other racial and ethnic groups. A higher percentage of hematologic cancer deaths had COVID-19 as the underlying cause (7.4%   No. of deaths of leukemia, 7.3% of non-Hodgkin lymphoma, and 5.8% of myeloma deaths) compared with 0.6% of pancreatic cancer deaths, 2.8% of breast cancer deaths, and 3.6% of prostate cancer deaths.

Discussion
Cancer was one of the first conditions to be linked with increased risk for severe COVID-19 morbidity and mortality (1). This report showed that the number of cancer deaths with cancer as the underlying cause increased slightly from 2018 to 2021, but relatively less than the increase in the number of deaths from cancer as any cause of death, indicating that an excess number of persons with cancer died from COVID-19 and other diseases. The number of cancer deaths that were due to noncancer underlying conditions was highest during winter months in 2021 and 2022, which correspond to peaks in COVID-19 infection. § § Whereas many of these cancer deaths listed COVID-19 as the underlying cause, other cancer deaths during this time might have had underlying conditions (e.g., heart disease) exacerbated by unreported COVID-19 illness or underlying conditions (e.g., drug overdose or cirrhosis) exacerbated by changes in health behaviors during the pandemic (3).
Some persons might be moderately or severely immunocompromised because of their cancer or cancer treatment, such as active treatment for solid tumors or blood cancers or high-dose corticosteroids or other drugs that suppress the immune system. ¶ ¶ Because hematologic cancers develop in the immune system, persons living with these cancers tend to have weakened immune systems and might be particularly susceptible to COVID-19 infection and disease progression (4). This report found that a disproportionately high percentage of persons with leukemia, lymphoma, myeloma, and other hematologic cancers died from COVID-19.
Up-to-date COVID-19 vaccination reduces the risk of severe COVID-19 illness (5). Additional doses in the primary series and boosters are generally recommended for persons who are moderately or severely immunocompromised.*** Health care providers can inform their cancer patients about the recommended COVID-19 vaccination series and the timing of COVID-19 vaccination administration relative to their cancer treatment (6). Up-to-date COVID-19 vaccination for close contacts has been shown to protect cancer patients from infection (7). Other interventions, such as mask use, physical The findings in this report are subject to at least three limitations. First, 2021 and 2022 data are provisional, and numbers might change as additional information is received. Second, ethnicity, race, or both might have been inaccurately recorded on death certificates,**** which might result in under-or overestimates of death counts in some groups. Finally, information about cancer diagnosis that might be related to prognosis, such as date of diagnosis, screening status, treatment status, or barriers to cancer care, was not available in the death certificate; some cancer survivors might have been in treatment when they died, whereas others might have had a remote history of cancer.
This report found disproportionately higher percentage of cancer deaths with COVID-19 as the underlying cause of death among persons who were older; male; categorized as Hispanic, AI/AN, and Black; or living with certain cancers, such as leukemia, lymphoma, and myeloma. These results could guide multicomponent COVID-19 prevention interventions and ongoing, cross-cutting efforts to reduce health disparities and address structural and social determinants of health among cancer survivors, which might help protect those at disproportionately increased risk for dying from COVID-19.