Vaccination Coverage Among Children Aged 19–35 Months — United States, 2016

Vaccination is the most effective intervention to reduce morbidity and mortality from vaccine-preventable diseases in young children (1). Data from the 2016 National Immunization Survey-Child (NIS-Child) were used to assess coverage with recommended vaccines (2) among children aged 19-35 months in the United States. Coverage remained ≥90% for ≥3 doses of poliovirus vaccine (91.9%), ≥1 dose of measles, mumps, and rubella vaccine (MMR) (91.1%), ≥1 dose of varicella vaccine (90.6%), and ≥3 doses of hepatitis B vaccine (HepB) (90.5%). Coverage in 2016 was approximately 1-2 percentage points lower than in 2015 for ≥3 doses of diphtheria and tetanus toxoids and acellular pertussis vaccine (DTaP), ≥3 doses of poliovirus vaccine, the primary Haemophilus influenzae type b (Hib) series, ≥3 HepB doses, and ≥3 and ≥4 doses of pneumococcal conjugate vaccine (PCV), with no changes for other vaccines. More direct evaluation of trends by month and year of birth (3) found no change in coverage by age 2 years among children included in combined data from the 2015 and 2016 NIS-Child (born January 2012 through January 2015). The observed decreases in annual estimates might result from random differences in vaccination coverage by age 19 months between children sampled in 2016 and those sampled in 2015, among those birth cohorts eligible to be sampled in both survey years. For most vaccines, 2016 coverage was lower among non-Hispanic black* (black) children than among non-Hispanic white (white) children, and for children living below the federal poverty level† compared with those living at or above the poverty level. Vaccination coverage was generally lower among children insured by Medicaid (2.5-12.0 percentage points), and was much lower among uninsured children (12.4-24.9 percentage points), than among children with private insurance. The Vaccines for Children§ (VFC) program was designed to increase access to vaccines among children who might not otherwise be vaccinated because of inability to pay. Greater awareness and facilitating use of VFC might be helpful in reducing these disparities. Efforts should also be focused on minimizing breaks in continuity of health insurance and eliminating missed opportunities to vaccinate children during visits to health care providers. Despite the observed disparities and small changes in coverage from 2015, vaccination coverage among children aged 19-35 months remained high and stable in 2016.

inability to pay.Greater awareness and facilitating use of VFC might be helpful in reducing these disparities.Efforts should also be focused on minimizing breaks in continuity of health insurance and eliminating missed opportunities to vaccinate children during visits to health care providers.Despite the observed disparities and small changes in coverage from 2015, vaccination coverage among children aged 19-35 months remained high and stable in 2016.
The NIS-Child uses a random-digit-dialing sample of landline and cellular telephone numbers to contact parents or guardians of children aged 19-35 months in the 50 states, the District of Columbia, selected local areas, and U.S. territories.¶ Parents/guardians are interviewed by telephone to collect sociodemographic and health insurance information for ageeligible children in the household.With consent of parent or guardian, a survey is mailed to all identified vaccination providers to collect dates and types of all vaccines administered to the child.Vaccination coverage estimates use only providerreported vaccination data.NIS-Child methodology, including weighting procedures, has been described previously.**The household interview response rate † † was 33.9% from the combined landline/cell phone sample.Among households with completed interviews, 54.6% had adequate vaccination data from providers, § § yielding 14,988 children available for determination of national coverage estimates for 2016.Logistic ¶ Estimates for states, selected local areas, and territories are available online at https://www.cdc.gov/vaccines/imz-managers/coverage/childvaxview/datareports/index.html.

Vaccination Coverage by Race/Ethnicity, Poverty Status, and Type of Health Insurance
Compared with white children, black children had lower coverage with ≥3 and ≥4 doses of DTaP, the primary and full series of Hib, ≥3 and ≥4 doses of PCV, ≥2 doses of HepA, the completed rotavirus vaccine series, and the 7-vaccine series (Table 2).For ≥3 doses of DTaP, the primary series of Hib, and ≥3 doses of PCV, these disparities were not statistically significant after adjustment for poverty status; however, for the remaining vaccines, racial/ethnic disparities persisted only among children living at or above poverty (data not shown).For example, coverage with ≥4 doses of DTaP was similar for white and black children below poverty (75.6% and 76.6%, respectively); among children living at or above poverty, coverage rates among white and black children were 86.8% and 77.2%, respectively.Among children at or above poverty, a higher proportion of black children than white children (25.8% of black children compared with 10.4% of white children) were living just above the poverty level (up to 138% of poverty).The proportion of white children living in households with an income to poverty ratio of ≥4 was twice that ¶ ¶ The combined 7-vaccine series (4:3:1:3*:3:1:4) includes ≥4 doses of DTaP; ≥3 doses of poliovirus vaccine; ≥1 dose of measles-containing vaccine; ≥3 or ≥4 doses of Hib (depending upon product type of vaccine); ≥3 doses of HepB; ≥1 dose of varicella vaccine; and ≥4 doses of PCV.
For most vaccines, coverage among children living below the federal poverty level was lower than coverage among those living at or above the federal poverty level (Table 2).The largest gaps were for rotavirus vaccine (12.7 percentage points), ≥4 PCV doses (7.4 percentage points), the 7-vaccine series (6.5 percentage points), and the full series of Hib (6.2 percentage points).HepB birth dose coverage was higher among children living below the poverty level.
Vaccination coverage varied widely by health insurance status, with highest coverage (other than for the HepB birth dose) among children with private insurance, and lowest among uninsured children (Table 2).Compared with children who had private insurance, percentage point differences for children insured by Medicaid ranged from -2.5 for ≥3 doses of poliovirus vaccine and ≥1 dose of varicella to -12.0 for rotavirus vaccination, and for uninsured children, ranged from -12.4 for ≥3 doses of HepB to -24.9 for ≥4 doses of PCV.A higher percentage of uninsured children had received no vaccinations (3.4%) compared with those insured by Medicaid (0.8%) or private insurance (0.6%).
below 90% for vaccines that require booster doses during the second year of life (≥4 doses of DTaP and PCV as well as Hib full series) and for other recommended vaccines (HepB birth dose, rotavirus, and HepA).Disparities in coverage persisted for black children and those living below the poverty level, and coverage was generally lower for children who were uninsured or covered by Medicaid than among those with private insurance.These disparities indicate that improvements are needed in access to and delivery of age-appropriate immunization to all children, regardless of insurance or financial status (i.e., "the immunization safety net").Health insurance and poverty status are interrelated factors associated with lower vaccination coverage in young children.Compared with children who had only private insurance, those with Medicaid had lower coverage, and those who were uninsured had much lower coverage, for most vaccines.Uninsured children, who account for 3.0% of the 2016 NIS-Child weighted sample, are eligible for the VFC program, which was designed to increase access to vaccination among children through age 18 years who might not otherwise be vaccinated because of inability to pay.Some families might not be aware of the VFC program, be unable to afford fees associated with visits to a vaccine provider, or might need assistance locating a physician who participates in the VFC program.Children living below poverty and up to a certain percentage above the poverty level are eligible for Medicaid (42.5% of 2016 NIS-Child population met the minimum Medicaid eligibility level of 138%) and are entitled to VFC vaccines.Barriers to health care access and use among the publicly insured include language barriers, lack of trust in providers, transportation problems, inconvenient office hours, and other provider-and system-level factors (4).Medicaid patients also tend to experience more breaks in insurance coverage than do privately insured children, and discontinuities in insurance coverage have been associated with lower vaccination coverage (5).NIS-Child establishes insurance status at the time of interview, ).† Except for rotavirus, vaccination coverage was assessed before the child reached age 24 months.The Kaplan-Meier method was used to account for censoring of vaccination status for children assessed before age 24 months.Rotavirus vaccination was assessed before the child reached age 19 months and might include some vaccinations reported as received after the maximum recommended age of 8 months, zero days.§ Estimated linear relationship between month and year of birth and vaccination coverage, based on weighted linear regression analysis using the inverse of the estimated variance of each point estimate to construct the weights.Estimated percentage point change over 12 consecutive birth months: 4+ DTaP -0.05 (-0.4,0.3); 3+ Poliovirus -0.3 (-0.5, -0.006); 1+ MMR 0.05 (-0.2, 0.3); Hib full series 0.2 (-0.1, 0.6); 3+ HepB 0.6 (0.3, 0.9); 1+ Varicella 0.1 (-0.1, 0.4); 4+ PCV 0.2 (-0.1, 0.6); 2+ HepA 1.7 (1.2, 2.3); Rotavirus 1.4 (1.0, 1.9).not necessarily at the time of recommended vaccination, with enrollment in insurance sometimes occurring after the time window for receipt of certain vaccines.CDC has undertaken a number of activities designed to elucidate potential barriers to early childhood vaccination from the perspective of the state immunization programs and health care providers enrolled in the VFC program.There are also plans to assess parental experience with and barriers to accessing vaccination services.
Lower vaccination coverage among black children than among white children has been explained by differences in poverty status in past years (6), but in 2016, racial disparities were found among children living at or above the poverty level for some vaccines.This might reflect incomplete control for poverty status, because black children living above poverty could still live in lower income households, on average, than do white children.In the 2016 NIS-Child, the proportion of white children living in households with an income to poverty ratio of ≥4 was twice that of black children.
During routine checks for accuracy of the 2016 NIS-Child data, statistically significant differences were observed in vaccination coverage by age 19 months estimated from the 2016 compared with the 2015 surveys, among birth cohorts eligible to be included in both survey years (3,7).These differences were observed for 9 of the 15 vaccine doses evaluated and might indicate a systematic change in bias of the survey from 2015 to 2016.However, no differences were found in survey respondent characteristics and survey operations, and no errors were identified in processing of survey data; thus, it is possible that these differences might be attributable to random variation.
The observed vaccination coverage differences among birth cohorts eligible for both survey years contributed to drops in annual estimates of vaccination coverage using the entire sample of survey respondents from 2015 to 2016, but do not provide evidence for change in vaccination coverage over time (3).When trends were assessed more directly by month and year of birth from January 2012 through January 2015 (3), coverage by age 2 years was stable for all vaccines.When trends Abbreviations: CI = confidence interval; DTaP = diphtheria and tetanus toxoids and acellular pertussis vaccine; HepA = hepatitis A vaccine; HepB = hepatitis B vaccine; Hib = Haemophilus influenzae type b vaccine; MMR = measles, mumps, and rubella vaccine; PCV = pneumococcal conjugate vaccine.* For 2012, children born January 2009-May 2011; for 2013, children born January 2010-May 2012; for 2014, children born January 2011-May 2013; for 2015, children born January 2012-May 2014; and for 2016, children born January 2013-May 2015.† Includes children who might have been vaccinated with diphtheria and tetanus toxoids, or diphtheria and tetanus toxoids and pertussis vaccine.§ Statistically significant (p<0.05)change in coverage compared with previous year.¶Includes children who may have been vaccinated with measles, mumps, rubella, and varicella vaccine.** Hib primary series: receipt of ≥2 or ≥3 doses, depending on product type received; full series: primary series and booster dose includes receipt of ≥3 or ≥4 doses, depending on product type received.† † One dose HepB administered from birth through age 3 days.§ § Includes ≥2 doses of Rotarix monovalent rotavirus vaccine (RV1), or ≥3 doses of RotaTeq pentavalent rotavirus vaccine (RV5).¶ ¶ The combined 7-vaccine series (4:3:1:3*:3:1:4) includes ≥4 doses of DTaP, ≥3 doses of poliovirus vaccine, ≥1 dose of measles-containing vaccine, the full series of Hib (≥3 or ≥4 doses, depending on product type of vaccine), ≥3 doses of hepatitis B vaccine, ≥1 dose of varicella vaccine, and ≥4 doses of PCV.
was used to assess the association of race/ethnicity with vaccination coverage, adjusting for poverty status.T-tests on weighted data were used to evaluate differences in coverage estimates by demographic characteristics; differences were considered to be statistically significant for p-values <0.05.
The local areas sampled separately for the 2016 NIS-Child included areas that receive federal Section 317 immunization funds and are included in the NIS-Child sample every year (Chicago, Illinois; New York, New York; Philadelphia County, Pennsylvania; Bexar County, Texas; and Houston, Texas) and two additional sample areas (El Paso County, Texas and Dallas County, Texas).The 2016 NIS-Child was also conducted in Guam, Puerto Rico, and the U.S. Virgin Islands.This report includes national estimates, excluding the territories.** Further details regarding the statistical methodology of NIS-Child are available in the NIS-Child Data User's Guide 2015, which is available at https://www.cdc.gov/vaccines/imz-managers/nis/datasets.html.† CASRO household response rate is equivalent to the American Association for Public Opinion Research type 3 response rate http://www.aapor.org/AAPOR_Main/media/publications/Standard-Definitions20169theditionfinal.pdf.§ § Children with receipt of at least one vaccination reported by a provider and those who received no vaccinations were considered to have adequate provider data.regression