Multisystem Inflammatory Syndrome in Children (MIS-C)

Holding the hand of a sick child.

MIS-C and COVID-19

CDC is investigating multisystem inflammatory syndrome in children, a rare but serious complication associated with COVID-19.

What is MIS-C?

Multisystem inflammatory syndrome in children (MIS-C) is a condition where different body parts can become inflamed, including the heart, lungs, kidneys, brain, skin, eyes, or gastrointestinal organs. Children with MIS-C may have a fever and various symptoms, including abdominal (gut) pain, vomiting, diarrhea, neck pain, rash, bloodshot eyes, or feeling extra tired. We do not yet know what causes MIS-C. However, many children with MIS-C had the virus that causes COVID-19, or had been around someone with COVID-19.

Can adults get MIS-C?

Since June 2020, several case reports and series have reported a similar multisystem inflammatory syndrome in adults (MIS-A). Learn more.

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Latest MIS-C Data Reported by States
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MIS-C Emergency Care

Contact your child’s doctor, nurse, or clinic right away if your child is showing symptoms of MIS-C or symptoms of COVID-19. Seek emergency care right away if your child is showing any of these emergency warning signs or other concerning signs:

  • Trouble breathing
  • Pain or pressure in the chest that does not go away
  • New confusion
  • Inability to wake or stay awake
  • Pale, gray, or blue-colored skin, lips, or nail beds, depending on skin tone
  • Severe abdominal pain

Call 911 or call ahead to your local emergency facility: Notify the operator that you are seeking care for someone who has or may have COVID-19.

Page last reviewed: February 25, 2021