Communicable Disease

Burmese Refugee Health Profile

Parasitic Infections

Resettling refugees ≥1 years of age receive 400 mg of albendazole 48 hours prior to departure for the United States as a presumptive treatment for helminthiasis. Approximately 20% of new arrivals into Texas between June 2009 and May 2011 had positive O&P stool samples during post-arrival screening exams7. Of 295 records that specified a parasite, more than 50% were positive for Giardia, 36% for Dientamoeba, 20% for Entamoeba, and 2% or less for Ascaris, Clonorchis, hookworm, Schistosoma, Strongyloides, and Trichuris. On serological tests, a more sensitive means of detecting Strongyloides infection, of 272 refugees tested, 20% were positive7.

Intestinal Parasite Infection

There are a number of intestinal parasitic infections that may be encountered in Burmese refugees. These are often parasites found commonly in populations residing in tropical areas, such as Ascaris, Trichuris, hookworm, and Giardia. This section will discuss specific infections that may be unique to, or of particular concern, in this population.


Strongyloidiasis is a parasitic nematode infection that is common in Asian refugees and is known to persist for more than 50 years in the human host. Infection is frequently asymptomatic, but may lead to morbidity and, when the infected individual is immunosuppressed, even result in death.

Unpublished data from Minnesota have found seroprevalence of Strongyloides infection among Burmese refugees originating in Thailand who arrived in the United States in 2009-2012 to be ~10% (241/2304). Another study of Karen Burmese refugees arriving in Australia from Thailand (2006-2009) found a seroprevalence of 21%, and unpublished serologic data of Burmese refugees arriving in Texas showed a rate of 40% (191/663) of the samples tested 8. Although only limited serologic data on Burmese refugees originating in Malaysia exist, of 995 serum specimens tested, 21% (198) of samples were positive. The CDC currently recommends that all U.S.-bound Burmese refugees either be presumptively treated for strongyloidiasis overseas or, if they have not been treated overseas, be tested and treated (if positive) after arrival in the United States.

The treatment of choice for Strongyloides infection is ivermectin, given once daily for two consecutive days. Currently, all resettlement eligible Burmese refugees, whether they originate in Thailand or in Malaysia, are receiving ivermectin prior to departure for the United States. Ivermectin is thought to be more than 90% effective in treating Strongyloides infection, although it may not eradicate all infections9. If a refugee has persistent symptoms, or persistent eosinophilia (> 3 months after arrival in the United States), strongyloidiasis should still be considered in the differential diagnosis. In this case, it is reasonable to perform serologic testing and/or repeat presumptive treatment, especially if the patient will be immunosuppressed or placed on corticosteroids. For more information on strongyloidiasis follow this link.

For the domestic guidelines for diagnosis and management of parasites in refugees, please see the current Domestic Intestinal Parasite Guidelines for refugees.


Cysticercosis is an infection with the larval stage of the parasitic cestode (tapeworm) Taenia solium.  Both pigs and humans may be infected by ingesting eggs or gravid proglottids. The adult tapeworm resides in the human intestine, where it occasionally may causes mild gastrointestinal symptoms. This is called taeniasis.  Cysticercosis is usually caused when a human ingests eggs shed in the feces of a human tapeworm carrier (although they may also experience cysticercosis from autoinfection). The lifecycle may be visualized here. Cysticercosis occurs when oncospheres hatch in the intestines and invade the intestinal wall, migrating into striated muscle, the brain, liver, or other tissues, where they develop into cysts (“cysticerci”). When cysticerci are found in the central nervous system, the infection is referred to as neurocysticercosis (NCC), which, when symptomatic, most commonly presents with seizures. Treatment of NCC is complicated, and consultation with a specialist familiar with this disorder is recommended prior to initiating treatment. Further information is available here.

Inadvertent treatment of a person with NCC with certain antiparasitics (e.g., albendazole, praziquantel) may precipitate symptoms such as seizures. Therefore, patients with known NCC or a seizure disorder should not be treated with these medications until a formal neurologic evaluation has been performed.

Although data specific to Burmese refugees are not available, intestinal infection with the adult tapeworm (taeniasis) is typically seen on stool ova and parasite (O&P) screening in ~1-2% of all refugees following arriving in the United States. It is not possible to distinguish between T. solium and other Taenia tapeworms on stool O&P unless a proglottid is seen.  While routine stool studies of asymptomatic refugees are not indicated given this low overall prevalence rate, when a family member has known infection (either intestinal or cysticercosis), screening of family members and close contacts stool and ova parasite examinations is indicated. In addition, diagnostic testing with stool O&Ps should be considered in those with gastrointestinal signs or symptoms, if they report or bring in a proglottid passed in their stool (generally about the size of a piece of rice). Use of albendazole or praziquantel should be restricted to those without a history of seizures or known NCC. Assistance with screening, diagnosis, and treatment may be obtained from CDC’s Division of Parasitic and Malaria Diseases (DPDM).

Trematode Infections

Trematode (“fluke”) infections occur worldwide, but each infection has a specific geographic distribution. Human infection is largely determined by dietary or environmental exposure in endemic areas. All fluke infections may be persistent and last many years following exposure. Although the most common trematode infection is schistosomiasis, considered the only “blood-fluke”, Myanmar, areas of Thailand and Malaysia, where refugees from Burma have resided, are not endemic. However, other trematodes that may be encountered in these refugees and include: Paragonimus westermani (lung fluke), the liver flukes (Clonorchis sinensis, Fasciola hepatica, Opisthorchis viverrini) and the intestinal flukes (Fasciolopsis buski, Heterophyes heterophyes, and Metagonimus yokogawai). These trematode infections are acquired through ingestion of specific food items. Although Burmese refugees may be exposed to multiple trematode species, the most commonly encountered trematodes in this population are Paragonimus westermani and Clonorchis sinensis, which are discussed below.


Paragonimus, also known as lung fluke, is acquired from eating raw or undercooked freshwater crab or crayfish, which is a common practice in many Burmese populations (where preparation of these crustaceans is done with vinegar, brine, or wine without cooking; therefore, failing to kill the organism). Following consumption of the metacercariae and the development of the adult worm, Paragonimus will make its way to the pulmonary system, where it induces inflammation and generates fibrous cysts containing purulent, bloody fluid and may cause an effusion. The eggs are subsequently released into the environment through expectoration, or may be swallowed and passed in the stool. Most infected individuals have no or subtle symptoms. The most common clinical presentation resembles a chronic bronchitis or tuberculosis with cough, which is frequently productive of coffee-colored or blood tinged sputum, chest pain, and/or shortness of breath. The sputum may be “peppered” with visible clumps of eggs. It commonly causes chest radiograph (CXR) abnormalities such as lobar infiltrates, coin lesions, cavities, calcified nodules, hilar enlargement, and, particularly, pleural thickening and effusions. CXR findings of “ring-shaped opacities” of contiguous cavities, often referred to as a “grapebunch,” is suggestive of this infection. Central nervous system (CNS) infection does occur and should be considered in persons with symptoms such as headaches, seizures, visual changes, or other CNS symptoms. Paragonimus may also invade the liver, spleen, intestinal wall, peritoneum, and abdominal lymph nodes.

No Paragonimus prevalence data are available in Burmese refugees, but there have been many clinical cases diagnosed in refugees following their arrival in the United States. Diagnosis can be challenging, but for patients with pulmonary signs or symptoms, sputum O&Ps examination may be helpful (note: acid fast bacilli staining for TB will destroy the eggs and sputum O&P should not be stained for acid fast bacilli). Stool O&P may be diagnostic, but has low sensitivity for detecting infection.   Serum antibody testing is also available. Information about Paragonimus, including information on diagnosis and treatment, is available here. Generally, when paragonimiasis is suspected, an expert should be consulted.

Clonorchis sinensis

Clonorchis (“liver fluke”) infects the liver, gallbladder, and bile ducts. In addition to humans, the reservoir species include dogs and other fish-eating carnivores. Infection is acquired when a human ingests raw, salted, pickled, smoked, marinated, dried, partially or poorly cooked fish. Most individuals have no or minimal symptoms.  The most common finding in refugees is a persistently elevated eosinophil count. Common symptoms include fever, right-upper quadrant pain, and intermittent biliary colic pain (when the worms obstruct the biliary tract). Chronic infection may result in recurrent pyogenic cholangitis, and is associated with cholangiohepatitis. Infection may be confused with gallstones and cholecystitis (tip: on ultrasound, the fluke is echogenic and appears dark, compared to a gallstone, which is generally lighter in appearance).  Chronic infection with Clonorchis sinensis has been associated with biliary cancer, and the International Agency for Research on Cancer (IARC) has classified it as a Group 1 agent (carcinogenic in humans).

Risk of infection is highly dependent on diet, and the infection has been detected in Burmese refugees (the greatest number of cases in U.S. refugees historically has occurred in the Hmong)7. When suspected, the first diagnostic tests indicated are multiple stool O&Ps and ultrasound of the liver and biliary tract. Diagnosis can be challenging, since these tests are not sensitive. Serologic testing is available outside the United States. Generally, when Clonorchis infection is suspected, an expert should be consulted. Further information is available from the CDC, Division of Parasitic Diseases.


Malaria is prevalent in Myanmar, with the most common species being P. falciparum (which causes acute malaria) and P. vivax (which may cause acute malaria or become dormant in the liver, emerging months, or even years, later, causing clinical malaria). Refugee camps are situated in Thailand along the border with Myanmar, and there is frequent travel between the two countries. Although malaria in Thailand is unusual, this cross-border travel and the proximity to Myanmar creates an opportunity for acute clinical cases of malaria in Burmese refugees residing in these camps. There is no sustained malaria transmission in Kuala Lumpur, Malaysia. Refugees originating from Malaysia (Kuala Lumpur) are not at risk of acute malaria. However, most Burmese refugees who have resided in Myanmar have had exposure to areas of P. vivax during their lifetime and may harbor dormant infection. This infection may reactivate following immigration to the United States. At present, the presumptive antimalarial treatment program for refugee populations at high risk of malaria prior to immigration to the United States is only in effect in sub-Saharan Africa. At this time, malaria prevalence rates in Burmese refugees in Thailand are not substantial enough to warrant presumptive treatment in this population. Refugees with P. falciparum infection who are from regions of lower prevalence would be expected to show clinical signs of disease (in highly endemic areas, such as many areas of Africa, P. falciparum malaria parasitemia may be asymptomatic or sub-clinical). In addition, common medications used to treat acute malaria do not treat the dormant liver phase of P. vivax.

The clinician should be aware that clinical malaria may occur in Burmese refugees, with those originating in Thailand at highest risk. In addition, it should be noted that P. vivax relapse may occur many months, or even years, following migration. Any patient with clinical signs and symptoms of malaria should be tested for infection. The CDC provides clinical consultation support for providers seeking information on the diagnosis and management of malaria.

Sexually Transmitted Infections and HIV

Chlamydia and Gonorrhea

The current Refugee Domestic Screening Guidelines for Sexually Transmitted Diseases suggest routine screening for chlamydia in women < 25 years old who are sexually active, and testing any refugees with known risk factors or signs of infection for chlamydia and gonorrhea.

There are limited data available on rates of chlamydia and gonorrhea in Burmese refugees. Unpublished data screening data from Minnesota showed that of the approximately 33% of Burmese refugee arrivals who were screened from 2009-2012, only 1% (11/1007) were positive for chlamydia and 0% (0/982) were positive for gonorrhea (Table 1). All cases of chlamydia occurred in persons aged 15-44 years of age. No data have been published or identified regarding rates of chlamydia or gonorrhea in Burmese refugees originating in Malaysia. Prevalence in Burmese refugees arriving from Malaysia may differ from those originating from Thailand because, for example, Malaysian refugees largely live in urban centers (while those from Thailand residing in refugee camps, often in rural areas). However, given the low rates reported in those from Thailand and the overall low rates in refugees, the current CDC guidelines are felt to be sufficient for these populations (screening for chlamydia in women < 25 years old who are sexually active, or testing refugees for chlamydia and gonorrhea if there are known risk factors or signs of infection [e.g., discharge, elevated white blood count, or leukocyte esterase-positive urine sample]).

Table 1. Chlamydia and Gonorrhea Results Among Burmese Primary Refugee Arrivals to Minnesota, 2009-2012

Age at US Arrival (years) No. Screened
Screened for Chlamydia Chlamydia Result Screened for Gonorrhea Gonorrhea Result
Positive Negative Positive Negative
No. % No. % No. % No. % No. % No. %
0-5 440 5 1% 0 0% 5 100% 4 1% 0 0% 4 100%
5-14 763 33 4% 0 0% 33 100% 33 4% 0 0% 33 100%
15-24 748 412 55% 6 1% 406 99% 392 52% 0 0% 392 100%
25-44 749 376 50% 5 1% 371 99% 373 50% 0 0% 373 100%
45-64 296 154 52% 0 0% 154 100% 154 52% 0 0% 154 100%
≥65 54 27 50% 0 0% 27 100% 26 48% 0 0% 26 100%
Total 3,050 1,007 33% 11 1% 996 99% 982 32% 0 0% 982 100%

*Received a post-arrival refugee health assessment, usually initiated within 90 days of U.S. arrival.

Human Immunodeficiency Virus

Refugees resettling to the United States do not receive routine pre-departure/overseas screening for HIV infection. It is currently recommended that all refugees be screened for HIV following arrival in the United States. Unpublished data from Texas (2009-2012) showed that 1.7% (84/4831) of Burmese refugees originating from Malaysia and 0.3% (14/4146) of Burmese refugees originating from Thailand had HIV infection. Similar data from Minnesota (2009-2012) reported a low prevalence among Burmese refugees arriving in Minnesota from Thailand (2/2505). Given that early identification and treatment of infection reduces morbidity and mortality and decreases transmission, it remains imperative that refugees receive post-arrival HIV screening.


All refugees > 15 years of age are required to have syphilis testing prior to departure for the United States. Unpublished data from Texas showed that ~0.5% of Burmese refugees (n=7458) had a positive screening test for syphilis. The current Refugee Domestic Screening Guidelines for Sexually Transmitted Diseases note that repeat testing is not necessary when overseas documentation is available. When documentation is not available, refugees > 15 years of age should receive testing during the domestic medical evaluation. In children younger than 15 years or age, testing should be performed on those who are at risk (i.e., mother tests positive for syphilis). Guidance regarding syphilis testing and treatment is available in the CDC Sexually Transmitted Diseases Treatment Guidelines, 2010.

Hepatitis B and C

Persons with chronic hepatitis B virus (HBV) infection are at risk for developing chronic liver disease, including cirrhosis and hepatocellular carcinoma, as well as extrahepatic manifestations such as glomerulonephritis. Burmese refugees originating in Thailand have been documented to have a chronic HBV infection prevalence of 8-10% (6,569 refugees screened from 2009-2012 in Minnesota and Texas). Prevalence in Karen Burmese refugees originating from Thailand and arriving in Australia was similar at 9.7% (of 1136 new arrivals)8. Data from Burmese refugees originating in Malaysia are more limited, but among 5,102 refugees screened in Texas from 2009-2012, there was a 6% rate of chronic HBV infection. It is currently recommended that all refugees from countries with rates > 2% be screened for chronic HBV infection , which include all groups of Burmese refugees.

Chronic infection with hepatitis C virus (HCV) may also lead to cirrhosis and hepatocellular carcinoma. The current recommendations for screening for HCV infection in the United States include routine screening of those born between 1945 and 1965, and screening of persons with known risk factors for HCV infection (such as patients with history of injection drug use, HIV-positive patients, patients who received blood products prior to migration, children of parents with known hepatitis C). Data on HCV infection rates in refugees are limited, and, currently, the CDC domestic screening guidelines recommend that refugees be screened according to existing CDC guidelines for the United States population. In Minnesota from 2009-2012, 1,746 (56%) Burmese refugees arriving from Thailand were screened for HCV infection (n=3050). Of these, 54 (3%) screened positive for HCV infection, with 34 found to have confirmed infection by viral load (for an overall rate of 2.2%). The highest prevalence of HCV infection was among those aged 45-64 years (Table 2). Screening data from Texas over the same time period identified a 2.2% (79/3557) seropositive rate in Burmese refugees originating in Thailand and a 2.8% (113/4098) seropositive rate in Burmese refugees originating in Malaysia (confirmatory testing not available). Since Minnesota and Texas do not routinely screen all refugees and instead focus on those in higher-risk groups, these rates may be inaccurately elevated since clinicians are more likely to test those at increased risk for infection. Data from Karen Burmese refugees arriving in Australia showed a similar HCV infection rate of 1.9% (n=1136)8. A majority of cases occurred among those aged 45-64 years. These data indicate that routine screening should be done in arriving refugees born between 1945 and 1965, as well as those with known risk factors.

Table 2. Hepatitis C Screening Among Burmese Primary Refugee Arrivals to Minnesota, 2009-2012

Age at US Arrival (years) No. Screened
Screened for Hepatitis C** Hepatitis C Result***
Positive Negative Indeterminate
No. % No. % No. % No. %
0-5 440 237 54% 0 0% 237 100% 0 0%
5-14 763 410 54% 0 0% 410 100% 0 0%
15-24 748 448 60% 6 1% 440 98% 2 <1%
25-44 749 439 59% 21 5% 417 95% 1 <1%
45-64 296 180 61% 25 14% 153 85% 2 1%
≥65 54 32 59% 2 6% 30 94% 0 0%
Total 3,050 1,746 57% 54**** 3% 1,689 97% 5 <1%

*Received a post-arrival refugee health assessment, usually initiated within 90 days of U.S. arrival
**Screened using hepatitis C antibody (anti-HCV) test
*** Recorded as negative if initial anti-HCV result positive and confirmatory result negative
****34 (63%) with a known positive confirmatory test result and 6 (11%) with an indeterminate confirmatory test result


  1. Stauffer, W.M., J.S. Sellman, and P.F. Walker, Biliary liver flukes (Opisthorchiasis and Clonorchiasis) in immigrants in the United States: often subtle and diagnosed years after arrival. J Travel Med, 2004. 11(3): p. 157-9.
  2. Paxton, G.A., et al., Post-arrival health screening in Karen refugees in Australia. PLoS One, 2012. 7(5): p. e38194.
  3. Gann, P.H., F.A. Neva, and A.A. Gam, A randomized trial of single- and two-dose ivermectin versus thiabendazole for treatment of strongyloidiasis. J Infect Dis, 1994. 169(5): p. 1076-9.