HPV Vaccine Schedule and Dosing

HPV Vaccination Schedule
Routine vaccination Age 11–12 years;
can be started at age 9 years
Catch-up Vaccination* Age 13–26 years,
if not adequately vaccinated
Shared clinical decision-making* Some adults age 27–45 years,
if not adequately vaccinated

*MMWR. 2019;68(32);698-702

About 85% of people will get an HPV infection in their lifetime. Vaccinating all 11–12-year-olds can protect them long before they are ever exposed.

CDC recommends two doses of HPV vaccine for all adolescents at age 11 or 12 years.

Who Gets Two Doses?
9-14 year old
  • A 2-dose schedule is recommended for people who get the first dose before their 15th birthday. In a 2-dose series, the second dose should be given 6–12 months after the first dose (0, 6–12-month schedule).
  • The minimum interval is 5 months between the first and second dose. If the second dose is administered after a shorter interval, a third dose should be administered a minimum of 5 months after the first dose and a minimum of 12 weeks after the second dose.
  • If the vaccination schedule is interrupted, vaccine doses do not need to be repeated (no maximum interval).
  • Immunogenicity studies have shown that two doses of HPV vaccine given to 9–14-year-olds at least 6 months apart provided as good or better protection than three doses given to older adolescents or young adults.
Who Gets Three Doses?

A 3-dose schedule is recommended for people who get the first dose on or after their 15th birthday, and for people with certain immunocompromising conditions.

  • In a 3-dose series, the second dose should be given 1–2 months after the first dose, and the third dose should be given 6 months after the first dose (0, 1–2, 6-month schedule).
  • The minimum intervals are 4 weeks between the first and second dose, 12 weeks between the second and third doses, and 5 months between the first and third doses. If a vaccine dose is administered after a shorter interval, it should be re-administered after another minimum interval has elapsed since the most recent dose.
  • If the vaccination schedule is interrupted, vaccine doses do not need to be repeated (no maximum interval).

Adolescent Vaccination Schedules

Common questions about the HPV Vaccine Schedule