HIV and Pregnant Women, Infants, and Children
Perinatal HIV transmission (also known as mother-to-child transmission) can happen at any time during pregnancy, childbirth, and breastfeeding. However, today there are effective interventions for preventing perinatal HIV transmission, and the number of infants with HIV in the United States has declined dramatically.
All women who are pregnant or planning to get pregnant should take an HIV test as soon as possible. The earlier HIV is diagnosed and treated, the more effective HIV medicine (antiretroviral therapy, or ART) will be at preventing transmission.
Preventing Perinatal HIV Transmission
Advances in HIV research, prevention, and treatment have made it possible for many women with HIV to give birth to babies who are free of HIV. The annual number of HIV infections through perinatal transmission has declined by more than 95% since the early 1990s.
*Viral suppression is defined as having less than 200 copies of HIV per milliliter of blood. An undetectable viral load means having a viral load so low that a test can’t detect it. The benefits of having an undetectable viral load also apply to people who stay virally suppressed.
All women who are pregnant or trying to get pregnant should encourage their partners to also get tested for HIV.
- HIV-negative women who have a partner with HIV should talk to their doctor about taking HIV medicine daily, called pre-exposure prophylaxis (PrEP), to protect themselves while trying to get pregnant, and to protect themselves and their baby during pregnancy and while breastfeeding.
- If either partner has HIV, that partner should take HIV medicine daily as prescribed to stay healthy and prevent transmission.
People with HIV who take HIV medicine as prescribed and get and keep an undetectable viral load (or stay virally suppressed) have effectively no risk of transmitting HIV to their HIV-negative sexual partners.
For babies with HIV, starting treatment early is important because the disease can progress more quickly in children than adults. Providing HIV medicine early can help children with perinatal HIV live longer, healthier lives.
Perinatal HIV Transmission
- We don’t know exactly how many women with HIV give birth annually in the United States. An estimate for 2006 suggested that approximately 8,500 women with HIV were giving birth annually. More recent evidence suggests that the number is less than 5,000.
- In 2017, 73 children under the age of 13 received a diagnosis of perinatally acquired HIV in the United States and dependent areas.a
Diagnoses of Perinatal HIV Infections in the US and Dependent Areas by Race/Ethnicity, 2017
Source: CDC. Diagnoses of HIV infection in the United States and dependent areas. HIV Surveillance Report 2017;29.
Hispanics/Latinos can be of any race.
Diagnoses of Perinatal HIV Infections in the US and Dependent Areas
Source: CDC. Diagnoses of HIV infection in the United States and dependent areas, 2017. HIV Surveillance Report 2017;29.
Rates of Perinatally Acquired HIV Infections by Year of Birth and Mother’s Race/Ethnicity, 2010-2015
Source: Monitoring selected national HIV prevention and care objectives by using HIV surveillance data—United States and 6 dependent areas, 2016. HIV Surveillance Supplemental Report 2018;23(4).
Data include only persons born in the United States (50 states and District of Columbia). Data accounted for delays between birth and diagnosis, as well as between diagnosis and reporting.
Rates are per 100,000 live births.
Live-birth data reflect race/ethnicity of the infant’s mother.
Hispanics/Latinos can be of any race.
Living With HIV
In the US and dependent areas:
- At the end of 2016, 1,814 childrenb were living with diagnosed perinatal HIV. Of these 1,139 (63%) were black/African American, 269 (15%) were Hispanic/Latino,c and 195 (11%) were white.
- At the end of 2016, 10,101 adults and adolescents (aged 13 and older) were living with diagnosed HIV acquired through perinatal transmission. Of these, 57% (5,757) were black/African American, 26% (2,591) were Hispanic/Latino, and 11% (1,135) were white.
- Pregnant women with HIV may not know they have the virus. CDC recommends HIV testing for all women as part of routine prenatal care. According to CDC research, more women take the prenatal HIV test if the opt-out approach is used. Opt-out prenatal HIV testing means that a pregnant woman is told she will be given an HIV test as part of routine prenatal care unless she opts out—that is, chooses not to have the test. In some parts of the country where HIV among women is more common, CDC recommends a second test during the third trimester of pregnancy.
- In 2016, the American Medical Association created a new Common Procedural Terminology (CPT) code that includes HIV testing in the Obstetric Panel . This allows prenatal care providers to order just one panel that includes many standard serologic tests for pregnant women, including HIV.
- Women with HIV may not know they are pregnant, how to prevent or safely plan a pregnancy, or what they can do to keep their baby from getting HIV.
- To get the full protective benefit of HIV medicine, the mother needs to take it as prescribed—without interruption—throughout pregnancy and childbirth, and provide HIV medicine to her infant. Pregnant women with HIV may have nausea during pregnancy that can interfere with taking medicines, and new mothers may not be able to see their HIV medical care provider consistently.
- Social and economic factors, especially poverty, affect access to health care, and disproportionately affect people living with HIV. Pregnant women with HIV may face more barriers to accessing medical care and staying on treatment if they also inject drugs, use other substances, are experiencing homelessness, or are incarcerated, mentally ill, or uninsured.
What CDC Is Doing
- CDC has developed a framework to guide federal agencies and other organizations in their efforts to reduce the rate of perinatal transmission of HIV to less than 1% among infants born to women with HIV and less than 1 perinatal transmission per 100,000 live births. These are the goals that CDC has developed for elimination of mother-to-child HIV transmission in the United States.
- CDC supports CityMatCH to convene a group of stakeholders including public health professionals and clinical care providers to implement the CDC framework.
- CDC funds perinatal HIV prevention through the Integrated Human Immunodeficiency Virus Surveillance and Prevention Programs for Health Departments. Key partner activities include promoting HIV testing and ART for pregnant women; an HIV surveillance and birth registry match to identify mother-infant pairs in need of services; perinatal HIV exposure surveillance; and a community-based quality improvement process using case reviews, that is, the FIMR-HIV methodology, and perinatal HIV services coordination.
a American Samoa, Guam, the Northern Mariana Islands, Puerto Rico, the Republic of Palau, and the US Virgin Islands.
b Children under the age of 13.
c Hispanics/Latinos can be of any race.
- Diagnoses of HIV infection in the United States and dependent areas, 2017. HIV Surveillance Report 2018;29.
- Monitoring selected national HIV prevention and care objectives by using HIV surveillance data—United States and 6 dependent areas—2017. HIV Surveillance Supplemental Report 2016;23(4).
- Nesheim SR, FitzHarris LF, Lampe MA, Gray KM. Reconsidering the number of women with HIV infection who give birth annually in the United States. Public Health Rep 2018; 133(6): 637-43. PubMed abstract.
- Little KM, Taylor AW, Borkowf CB, et al. Perinatal Antiretroviral Exposure and Prevented Mother-to-child HIV Infections in the Era of Antiretroviral Prophylaxis in the United States, 1994-2010. Pediatr Infect Dis J 2017 Jan; 36(1), 66-71.
- Panel on Treatment of HIV-Infected Pregnant Women and Prevention of Perinatal Transmission. Recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV transmission in the United States. AIDSinfo 2016; D1-D10. Accessed January 3, 2019.
- Pediatric HIV surveillance (through 2014). Slide set.
- Townsend CL, Cortina-Borja M, Peckham CS, de Ruiter A, Lyall H, Tookey, PA. Low rates of mother-to-child transmission of HIV following effective pregnancy interventions in the United Kingdom and Ireland, 2000–2006. AIDS 2008;22(8):973-81.
- Achievements in public health: reduction in perinatal transmission of HIV infection—United States, 1985–2005. MMWR 2006;55(21):592-97.
- Fleming PL, Lindegren ML, Byers R, et al. Estimated number of perinatal HIV infections, U.S., 2000. Poster Exhibition: XIV International AIDS Conference. Barcelona, Italy. 2002 Jul 7–12;14: Abstract No. TuPeC4773.
- Whitmore SK, Zhang X, Taylor AW, Blair JM. Estimated number of infants born to HIV-infected women in the United States and five dependent areas, 2006. J Acquir Immune Defic Syndr 2011;57:218-22.
- Valverde E, Short W, Brady K, Frazier E, Beer L, Mattson C. HIV medical provider’s assessment of the reproductive plans of women receiving HIV care: Medical Monitoring Project Provider Survey, 2009. 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2011). Rome, Italy. 2011 Jul 17-20; Abstract No. TUPE307.
- Whitmore SW, Taylor AW, Espinoza L, Shouse FL, Lampe MA, Nesheim SR. Correlates of mother-to-child HIV transmission in the United States and Puerto Rico. Pediatrics 2012 Jan;129:e74-81.
- Taylor AW, Nesheim S, Whitmore S, et al. Estimated number and characteristics associated with perinatal HIV infections, 33 states, United States, 2003–2007. 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2011). Rome, Italy. 2011 Jul 17-20; Abstract No. TUPDC0103.
- Revised recommendations for HIV testing of adults, adolescents, and pregnant women in health-care settings. MMWR 2006;55(RR-14):1-17.
- Barrow RY, Newman LM, Douglas JM Jr. Taking positive steps to address STD disparities for African American communities. Sex Transm Dis 2008;35(12 Suppl):S1-S3.
- Gaur AH, Dominguez KL, Kalish ML, et al. Practice of feeding premasticated food to infants: a potential risk factor for HIV transmission. Pediatrics 2009;124:658-66.
- Lampe MA, Smith DK, Anderson GJ, Edwards AE, Nesheim SR. Achieving safe conception in HIV-discordant couples: the potential role of oral preexposure prophylaxis (PrEP) in the United States. Am J Obstet Gynecol 2011;204:488.e1-8.
- Luzuriaga K, Tabak B, Garber M, et al. HIV Type 1 (HIV-1) Proviral Reservoirs Decay Continuously Under Sustained Virologic Control in HIV-1–Infected Children Who Received Early Treatment. J Infect Dis 2014 May; 210 (10), 1529-1538.
Mother to Child Transmission Resources (AIDS Education and Training Centers)
Women, Children, and HIV (University of California, San Francisco)
Cervical Cancer and HIV (SmartGlobalHealth.org)
- Page last reviewed: March 29, 2019
- Page last updated: March 29, 2019
- Content source: Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention