Individual cases and outbreaks of hand, foot, and mouth disease (HFMD) occur around the world. Cases can occur anytime, but in countries like the United States with varying climates, cases occur more often in the spring to fall.

Since 1997, large outbreaks of HFMD associated with enterovirus 71 have been reported mostly in children in East and Southeast Asia. In these outbreaks, most children have typical symptoms of HFMD and recover without health complications. However, a small number of people develop severe complications that require hospitalization or even cause death.

Researchers are studying why these outbreaks occur and why some people have severe disease.

To learn more about outbreaks occurring in some countries in Asia, visit the World Health Organization Cdc-pdf[1.48 MB, 71 pages]External.