MTRR Allele and Genotype Frequencies



Available polymorphism(s)

rs number

Common Designations

Nucleotide change Amino acid

Genotyping method

rs1801394

Ex2-64A>G

Ile22Met
Ile49Met

TaqMan

 


By Race/Ethnicity

Variant Race-ethnicity Allele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1801394 A G AA AG GG
Non-Hispanic White 47.2 (45.9, 48.5) 52.8 (51.5, 54.1) <0.001 22.6 (20.9, 24.4) 49.1 (47.1, 51.1) 28.3 (26.7, 29.9) <0.001 0.74
Non-Hispanic Black 71.3 (69.1, 73.3) 28.7 (26.7, 30.9) 50.7 (47.8, 53.6) 41.1 (39.2, 43.1) 8.2 (6.8, 9.8) 0.82
Mexican American 73.9 (72.0, 75.8) 26.1 (24.2, 28.0) 55.0 (51.8, 58.1) 37.9 (34.7, 41.3) 7.1 (5.7, 8.9) 0.04
Total* 53.1 (51.5, 54.7) 46.9 (45.3, 48.5) 29.8 (27.7, 31.9) 46.7 (45.0, 48.5) 23.5 (22.0, 25.0)

* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

Variant Age (years) Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1801394 A G AA AG GG
12-19 57.3 (51.0, 63.3) 42.7 (36.7, 49.0) 0.015 34.2 (27.9, 41.2) 46.1 (41.6, 50.6) 19.7 (14.0, 27.0) 0.060
20-39 53.8 (51.4, 56.2) 46.2 (43.8, 48.6) 29.5 (26.0, 33.2) 48.6 (45.0, 52.2) 21.9 (19.7, 24.3)
40-59 53.9 (50.7, 57.2) 46.1 (42.8, 49.3) 32.1 (27.5, 37.1) 43.7 (38.2, 49.3) 24.2 (20.7, 28.1)
>=60 47.8 (45.2, 50.3) 52.2 (49.7, 54.8) 23.9 (20.8, 27.4) 47.7 (44.4, 50.9) 28.4 (25.7, 31.2)
Total 53.1 (51.5, 54.7) 46.9 (45.3, 48.5) 29.8 (27.7, 31.9) 46.7 (45.0, 48.5) 23.5 (22.0, 25.0)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

Variant Sex Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1801394 A G AA AG GG
Male 53.5 (50.7, 56.3) 46.5 (43.7, 49.3) 0.604 29.3 (26.3, 32.6) 48.4 (45.5, 51.2) 22.3 (19.3, 25.5) 0.335
Female 52.8 (51.4, 54.2) 47.2 (45.8, 48.6) 30.2 (28.2, 32.4) 45.2 (42.3, 48.0) 24.6 (22.8, 26.6)
Total 53.1 (51.5, 54.7) 46.9 (45.3, 48.5) 29.8 (27.7, 31.9) 46.7 (45.0, 48.5) 23.5 (22.0, 25.0)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)
Genotype
% (95% CI)
rs1801394 A G AA AG GG
Non-Hispanic White 12-19 49.7 (42.6, 56.8) 50.3 (43.2, 57.4) 25.4 (18.5, 33.8) 48.6 (42.1, 55.1) 26.0 (18.8, 34.8)
20-39 46.5 (43.6, 49.5) 53.5 (50.5, 56.4) 20.1 (15.9, 25.0) 52.9 (47.8, 57.9) 27.0 (24.0, 30.3)
40-59 49.8 (45.9, 53.7) 50.2 (46.3, 54.1) 27.2 (21.7, 33.6) 45.1 (38.7, 51.7) 27.6 (23.8, 31.9)
>=60 43.5 (40.9, 46.0) 56.5 (54.0, 59.1) 19.4 (16.4, 22.7) 48.2 (44.6, 51.9) 32.4 (29.4, 35.6)
Non-Hispanic Black 12-19 70.1 (66.5, 73.5) 29.9 (26.5, 33.5) 50.9 (46.2, 55.5) 38.5 (34.7, 42.4) 10.6 (7.8, 14.4)
20-39 69.6 (66.5, 72.5) 30.4 (27.5, 33.5) 47.2 (42.8, 51.8) 44.7 (40.8, 48.6) 8.1 (6.1, 10.7)
40-59 74.0 (69.5, 78.0) 26.0 (22.0, 30.5) 56.1 (49.7, 62.3) 35.8 (30.9, 41.0) 8.2 (5.5, 11.9)
>=60 73.1 (70.1, 76.0) 26.9 (24.0, 29.9) 51.5 (47.6, 55.3) 43.3 (39.5, 47.3) 5.2 (2.8, 9.4)
Mexican American 12-19 73.8 (68.5, 78.5) 26.2 (21.5, 31.5) 54.2 (46.5, 61.7) 39.2 (32.5, 46.4) 6.6 (3.5, 12.1)
20-39 74.6 (72.1, 76.9) 25.4 (23.1, 27.9) 55.8 (50.9, 60.6) 37.6 (32.2, 43.3) 6.6 (5.0, 8.8)
40-59 72.8 (69.8, 75.6) 27.2 (24.4, 30.2) 54.6 (50.9, 58.4) 36.4 (32.8, 40.1) 9.0 (6.3, 12.6)
>=60 73.1 (69.7, 76.3) 26.9 (23.7, 30.3) 52.8 (48.1, 57.4) 40.7 (36.1, 45.6) 6.5 (3.8, 10.9)

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By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)
Genotype
% (95% CI)
rs1801394 A G AA AG GG
Non-Hispanic White Male 48.0 (45.7, 50.3) 52.0 (49.7, 54.3) 22.3 (19.9, 24.9) 51.4 (47.9, 54.9) 26.3 (23.3, 29.6)
Female 46.4 (44.6, 48.3) 53.6 (51.7, 55.4) 23.0 (21.0, 25.1) 46.9 (43.4, 50.5) 30.1 (27.2, 33.1)
Non-Hispanic Black Male 71.0 (68.0, 73.9) 29.0 (26.1, 32.0) 50.3 (45.8, 54.9) 41.4 (37.8, 45.1) 8.3 (6.5, 10.4)
Female 71.5 (69.2, 73.6) 28.5 (26.4, 30.8) 51.0 (48.0, 54.0) 40.9 (38.5, 43.4) 8.1 (6.4, 10.1)
Mexican American Male 74.3 (71.0, 77.4) 25.7 (22.6, 29.0) 55.5 (49.6, 61.3) 37.6 (32.0, 43.5) 6.9 (5.4, 8.8)
Female 73.5 (71.4, 75.5) 26.5 (24.5, 28.6) 54.4 (51.7, 57.1) 38.2 (36.0, 40.5) 7.4 (5.7, 9.5)

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Page last reviewed: March 16, 2009 (archived document)