ITGB3 Allele and Genotype Frequencies



Available polymorphism(s)

rs number

Common Designations

Nucleotide change Amino acid

Genotyping method

rs5918

Ex3+11T>C

Leu59Pro

MGB Eclipse

 


 

By Race/Ethnicity

Variant Race-ethnicity Allele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs5918 C T CC CT TT
Non-Hispanic White 16.3 (15.0, 17.6) 83.7 (82.4, 85.0) <0.001 2.7 (1.8, 4.0) 27.2 (25.1, 29.4) 70.1 (67.9, 72.2) <0.001 0.81
Non-Hispanic Black 10.1 (9.2, 11.0) 89.9 (89.0, 90.8) 1.1 (0.7, 1.7) 18.0 (16.3, 19.8) 81.0 (79.2, 82.6) 0.59
Mexican American 9.7 (8.2, 11.3) 90.3 (88.7, 91.8) 1.3 (0.8, 2.1) 16.8 (14.8, 19.0) 81.9 (79.2, 84.4) 0.22
Total* 14.4 (13.3, 15.6) 85.6 (84.4, 86.7) 2.2 (1.5, 3.3) 24.4 (22.7, 26.2) 73.4 (71.4, 75.2)

* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

Variant Age (years) Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs5918 C T CC CT TT
12-19 12.6 (10.2, 15.4) 87.4 (84.6, 89.8) 0.306 1.7 (0.7, 4.4) 21.7 (18.3, 25.7) 76.5 (72.1, 80.4) 0.629
20-39 14.4 (12.7, 16.4) 85.6 (83.6, 87.3) 2.4 (1.3, 4.4) 24.0 (21.5, 26.7) 73.6 (70.7, 76.3)
40-59 15.3 (13.4, 17.3) 84.7 (82.7, 86.6) 2.2 (1.2, 3.9) 26.2 (22.5, 30.4) 71.6 (67.8, 75.2)
>=60 14.5 (13.3, 15.9) 85.5 (84.1, 86.7) 2.3 (1.7, 3.1) 24.5 (22.4, 26.7) 73.2 (70.9, 75.5)
Total 14.4 (13.3, 15.6) 85.6 (84.4, 86.7) 2.2 (1.5, 3.3) 24.4 (22.7, 26.2) 73.4 (71.4, 75.2)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

Variant Sex Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs5918 C T CC CT TT
Male 14.3 (12.6, 16.1) 85.7 (83.9, 87.4) 0.762 2.7 (1.8, 4.1) 23.1 (20.3, 26.2) 74.2 (71.0, 77.1) 0.069
Female 14.6 (13.3, 16.0) 85.4 (84.0, 86.7) 1.8 (1.1, 2.9) 25.6 (23.7, 27.5) 72.6 (70.4, 74.8)
Total 14.4 (13.3, 15.6) 85.6 (84.4, 86.7) 2.2 (1.5, 3.3) 24.4 (22.7, 26.2) 73.4 (71.4, 75.2)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)
Genotype
% (95% CI)
rs5918 C T CC CT TT
Non-Hispanic White 12-19 14.3 (11.1, 18.1) 85.7 (81.9, 88.9) 1.7 (0.5, 5.2) 25.1 (19.7, 31.6) 73.2 (66.6, 78.9)
20-39 16.8 (14.7, 19.2) 83.2 (80.8, 85.3) 3.1 (1.6, 6.0) 27.4 (24.4, 30.6) 69.5 (66.1, 72.6)
40-59 16.8 (14.7, 19.0) 83.2 (81.0, 85.3) 2.6 (1.3, 5.0) 28.4 (24.5, 32.8) 69.0 (65.0, 72.7)
>=60 15.8 (14.3, 17.4) 84.2 (82.6, 85.7) 2.6 (1.8, 3.7) 26.4 (24.2, 28.7) 71.0 (68.4, 73.5)
Non-Hispanic Black 12-19 9.2 (7.6, 11.1) 90.8 (88.9, 92.4) 1.0 (0.5, 1.7) 16.4 (13.6, 19.7) 82.6 (79.1, 85.6)
20-39 10.1 (8.7, 11.8) 89.9 (88.2, 91.3) 0.9 (0.4, 1.9) 18.4 (15.5, 21.9) 80.6 (77.4, 83.6)
40-59 10.9 (9.1, 13.2) 89.1 (86.8, 90.9) 1.6 (0.7, 3.4) 18.7 (15.5, 22.4) 79.7 (75.9, 83.0)
>=60 9.4 (6.8, 12.7) 90.6 (87.3, 93.2) 0.8 (0.2, 3.2) 17.2 (12.2, 23.7) 82.0 (75.6, 87.0)
Mexican American 12-19 7.5 (4.9, 11.5) 92.5 (88.5, 95.1) 0.0 (NA) 15.1 (9.7, 22.7) 84.9 (77.3, 90.3)
20-39 10.9 (9.3, 12.8) 89.1 (87.2, 90.7) 2.0 (1.1, 3.7) 17.8 (15.4, 20.5) 80.2 (77.2, 82.9)
40-59 8.6 (6.9, 10.7) 91.4 (89.3, 93.1) 0.6 (0.2, 2.1) 16.1 (13.3, 19.2) 83.3 (79.8, 86.4)
>=60 10.0 (6.5, 15.0) 90.0 (85.0, 93.5) 1.6 (0.2, 10.3) 16.8 (11.7, 23.7) 81.6 (74.1, 87.3)

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By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)
Genotype
% (95% CI)
rs5918 C T CC CT TT
Non-Hispanic White Male 16.3 (14.3, 18.5) 83.7 (81.5, 85.7) 3.2 (2.1, 4.9) 26.2 (22.7, 30.0) 70.6 (66.8, 74.1)
Female 16.3 (14.7, 18.0) 83.7 (82.0, 85.3) 2.2 (1.3, 3.6) 28.2 (25.8, 30.7) 69.7 (66.9, 72.3)
Non-Hispanic Black Male 9.6 (8.5, 10.8) 90.4 (89.2, 91.5) 1.0 (0.5, 2.0) 17.1 (15.2, 19.2) 81.9 (79.7, 83.8)
Female 10.5 (9.4, 11.7) 89.5 (88.3, 90.6) 1.1 (0.6, 2.1) 18.7 (16.4, 21.2) 80.2 (77.9, 82.3)
Mexican American Male 10.2 (8.7, 11.8) 89.8 (88.2, 91.3) 1.4 (0.7, 2.7) 17.5 (14.9, 20.5) 81.1 (78.1, 83.7)
Female 9.1 (7.2, 11.5) 90.9 (88.5, 92.8) 1.1 (0.5, 2.4) 16.0 (12.8, 19.9) 82.9 (78.7, 86.3)

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Page last reviewed: March 16, 2009 (archived document)