FGB Allele and Genotype Frequencies



 

Available polymorphism(s)

rs number

Common Designations

Nucleotide change Amino acid

Genotyping method

rs1800790

-462G>A

TaqMan

 


By Race/Ethnicity

Variant Race-ethnicity Allele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1800790 A G AA AG GG
Non-Hispanic White 19.4 (18.1, 20.7) 80.6 (79.3, 81.9) <0.001 3.4 (2.6, 4.5) 31.9 (30.1, 33.8) 64.6 (62.6, 66.6) <0.001 0.81
Non-Hispanic Black 5.5 (4.6, 6.6) 94.5 (93.4, 95.4) 0.6 (0.3, 1.3) 9.8 (8.0, 11.9) 89.6 (87.5, 91.3) 0.01
Mexican American 15.0 (13.5, 16.6) 85.0 (83.4, 86.5) 2.5 (2.0, 3.1) 24.9 (22.3, 27.8) 72.6 (69.6, 75.4) 0.82
Total* 17.6 (16.2, 19.1) 82.4 (80.9, 83.8) 3.3 (2.4, 4.4) 28.7 (26.8, 30.7) 68.0 (65.7, 70.2)

* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

Variant Age (years) Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1800790 A G AA AG GG
12-19 17.0 (13.8, 20.8) 83.0 (79.2, 86.2) 0.357 3.3 (1.8, 5.9) 27.5 (22.3, 33.4) 69.2 (62.9, 74.9) 0.163
20-39 18.3 (16.3, 20.5) 81.7 (79.5, 83.7) 3.0 (2.0, 4.5) 30.6 (28.0, 33.3) 66.4 (63.1, 69.6)
40-59 16.4 (14.2, 18.8) 83.6 (81.2, 85.8) 3.1 (2.1, 4.5) 26.6 (22.4, 31.3) 70.3 (65.8, 74.5)
>=60 18.5 (17.1, 20.0) 81.5 (80.0, 82.9) 4.0 (2.8, 5.7) 29.0 (26.7, 31.3) 67.0 (64.7, 69.2)
Total 17.6 (16.2, 19.1) 82.4 (80.9, 83.8) 3.3 (2.4, 4.4) 28.7 (26.8, 30.7) 68.0 (65.7, 70.2)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

Variant Sex Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1800790 A G AA AG GG
Male 18.0 (16.4, 19.8) 82.0 (80.2, 83.6) 0.447 3.4 (2.4, 4.8) 29.3 (26.7, 32.1) 67.3 (64.4, 70.1) 0.709
Female 17.3 (15.5, 19.2) 82.7 (80.8, 84.5) 3.2 (2.1, 4.8) 28.2 (26.1, 30.4) 68.6 (65.9, 71.3)
Total 17.6 (16.2, 19.1) 82.4 (80.9, 83.8) 3.3 (2.4, 4.4) 28.7 (26.8, 30.7) 68.0 (65.7, 70.2)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)
Genotype
% (95% CI)
rs1800790 A G AA AG GG
Non-Hispanic White 12-19 20.4 (15.7, 26.1) 79.6 (73.9, 84.3) 3.9 (1.9, 7.8) 33.0 (25.4, 41.6) 63.1 (53.8, 71.6)
20-39 19.9 (18.2, 21.8) 80.1 (78.2, 81.8) 2.8 (2.0, 4.1) 34.2 (31.4, 37.0) 63.0 (59.8, 66.0)
40-59 18.0 (15.7, 20.5) 82.0 (79.5, 84.3) 3.3 (2.2, 5.0) 29.4 (25.2, 34.0) 67.3 (62.8, 71.5)
>=60 19.8 (18.3, 21.3) 80.2 (78.7, 81.7) 4.3 (2.9, 6.2) 31.0 (28.6, 33.5) 64.7 (62.4, 66.9)
Non-Hispanic Black 12-19 6.4 (4.6, 8.9) 93.6 (91.1, 95.4) 0.4 (0.1, 1.8) 12.1 (8.5, 16.9) 87.5 (82.7, 91.2)
20-39 5.5 (4.3, 7.0) 94.5 (93.0, 95.7) 0.6 (0.2, 1.6) 9.9 (7.6, 12.7) 89.6 (86.8, 91.8)
40-59 5.7 (4.2, 7.8) 94.3 (92.2, 95.8) 0.9 (0.3, 3.0) 9.7 (7.2, 12.9) 89.4 (86.1, 92.0)
>=60 4.1 (2.8, 5.9) 95.9 (94.1, 97.2) 0.6 (0.1, 3.0) 6.9 (4.4, 10.5) 92.5 (89.1, 94.9)
Mexican American 12-19 15.8 (13.2, 18.7) 84.2 (81.3, 86.8) 3.5 (1.8, 6.7) 24.7 (19.4, 30.8) 71.9 (66.5, 76.7)
20-39 15.6 (12.9, 18.6) 84.4 (81.4, 87.1) 2.4 (1.4, 3.8) 26.4 (21.3, 32.3) 71.2 (65.4, 76.4)
40-59 13.3 (11.6, 15.1) 86.7 (84.9, 88.4) 2.5 (1.0, 5.7) 21.6 (19.4, 24.1) 75.9 (73.7, 78.0)
>=60 13.6 (11.0, 16.6) 86.4 (83.4, 89.0) 1.0 (0.3, 3.5) 25.1 (21.0, 29.6) 73.9 (68.8, 78.4)

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By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)
Genotype
% (95% CI)
rs1800790 A G AA AG GG
Non-Hispanic White Male 19.5 (17.8, 21.3) 80.5 (78.7, 82.2) 3.2 (2.4, 4.3) 32.5 (29.7, 35.5) 64.3 (61.2, 67.2)
Female 19.3 (17.5, 21.2) 80.7 (78.8, 82.5) 3.6 (2.3, 5.7) 31.4 (29.4, 33.5) 65.0 (62.5, 67.4)
Non-Hispanic Black Male 5.7 (4.7, 6.9) 94.3 (93.1, 95.3) 0.6 (0.2, 2.0) 10.3 (8.4, 12.7) 89.1 (86.9, 91.0)
Female 5.4 (4.0, 7.1) 94.6 (92.9, 96.0) 0.7 (0.3, 1.6) 9.4 (6.9, 12.7) 89.9 (86.6, 92.5)
Mexican American Male 15.5 (14.0, 17.1) 84.5 (82.9, 86.0) 2.7 (2.0, 3.8) 25.5 (23.4, 27.7) 71.7 (69.1, 74.2)
Female 14.4 (12.5, 16.4) 85.6 (83.6, 87.5) 2.2 (1.5, 3.4) 24.3 (20.6, 28.4) 73.5 (69.5, 77.1)

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Page last reviewed: March 16, 2009 (archived document)