CXCL12 Allele and Genotype Frequencies



Available polymorphism(s)

Common Designations

rs number

Nucleotide change Amino acid change

Genotyping method

rs169097

Ex5+709C>T MGB Eclipse

 


By Race/Ethnicity

Variant Race-ethnicity Allele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs169097 C T CC CT TT
Non-Hispanic White 99.7 (99.4, 99.8) 0.3 (0.2, 0.6) <0.001 99.4 (98.9, 99.7) 0.6 (0.3, 1.1) 0.0 (0.0, 0.1) <0.001 <0.01
Non-Hispanic Black 82.8 (80.7, 84.8) 17.2 (15.2, 19.3) 68.4 (64.7, 71.9) 28.9 (25.7, 32.4) 2.7 (1.9, 3.8) 0.46
Mexican American 99.0 (98.6, 99.4) 1.0 (0.6, 1.4) 98.1 (97.1, 98.7) 1.9 (1.3, 2.9) 0.0 (NA) 0.61
Total* 97.5 (96.8, 98.1) 2.5 (1.9, 3.2) 95.4 (94.1, 96.4) 4.3 (3.4, 5.5) 0.3 (0.2, 0.5)

* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

Variant Age (years) Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs169097 C T CC CT TT
12-19 96.4 (95.0, 97.4) 3.6 (2.6, 5.0) 0.001 93.2 (90.6, 95.1) 6.4 (4.5, 8.9) 0.4 (0.2, 0.9) 0.013
20-39 97.3 (96.2, 98.1) 2.7 (1.9, 3.8) 95.0 (93.0, 96.5) 4.5 (3.2, 6.4) 0.5 (0.3, 0.8)
40-59 97.9 (97.3, 98.4) 2.1 (1.6, 2.7) 96.0 (94.9, 96.9) 3.8 (2.9, 4.9) 0.2 (0.1, 0.4)
>=60 98.3 (97.6, 98.8) 1.7 (1.2, 2.4) 96.7 (95.4, 97.6) 3.2 (2.4, 4.4) 0.1 (0.0, 0.4)
Total 97.5 (96.8, 98.1) 2.5 (1.9, 3.2) 95.4 (94.1, 96.4) 4.3 (3.4, 5.5) 0.3 (0.2, 0.5)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

Variant Sex Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs169097 C T CC CT TT
Male 97.6 (96.9, 98.1) 2.4 (1.9, 3.1) 0.716 95.5 (94.3, 96.5) 4.1 (3.2, 5.2) 0.4 (0.2, 0.7) 0.434
Female 97.5 (96.6, 98.1) 2.5 (1.9, 3.4) 95.2 (93.6, 96.4) 4.5 (3.3, 6.1) 0.3 (0.2, 0.4)
Total 97.5 (96.8, 98.1) 2.5 (1.9, 3.2) 95.4 (94.1, 96.4) 4.3 (3.4, 5.5) 0.3 (0.2, 0.5)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)
Genotype
% (95% CI)
rs169097 C T CC CT TT
Non-Hispanic White 12-19 99.3 (97.5, 99.8) 0.7 (0.2, 2.5) 98.6 (95.0, 99.6) 1.4 (0.4, 5.0) 0.0 (NA)
20-39 99.9 (99.4, 100.0) 0.1 (0.0, 0.6) 99.8 (98.8, 100.0) 0.2 (0.0, 1.2) 0.0 (NA)
40-59 99.6 (99.3, 99.8) 0.4 (0.2, 0.7) 99.2 (98.5, 99.6) 0.7 (0.3, 1.5) 0.1 (0.0, 0.5)
>=60 99.8 (99.3, 99.9) 0.2 (0.1, 0.7) 99.6 (98.7, 99.9) 0.4 (0.1, 1.3) 0.0 (NA)
Non-Hispanic Black 12-19 82.4 (79.1, 85.3) 17.6 (14.7, 20.9) 67.5 (62.0, 72.6) 29.7 (25.0, 34.9) 2.8 (1.5, 5.1)
20-39 82.2 (78.7, 85.3) 17.8 (14.7, 21.3) 68.2 (62.6, 73.4) 28.0 (23.6, 32.8) 3.8 (2.4, 6.0)
40-59 84.0 (81.0, 86.6) 16.0 (13.4, 19.0) 69.5 (63.7, 74.8) 29.0 (23.7, 35.0) 1.5 (0.9, 2.5)
>=60 83.4 (79.7, 86.5) 16.6 (13.5, 20.3) 68.0 (61.6, 73.7) 30.8 (25.3, 37.0) 1.2 (0.3, 4.8)
Mexican American 12-19 98.4 (97.4, 99.1) 1.6 (0.9, 2.6) 96.9 (94.8, 98.2) 3.1 (1.8, 5.2) 0.0 (NA)
20-39 99.1 (98.1, 99.6) 0.9 (0.4, 1.9) 98.2 (96.3, 99.2) 1.8 (0.8, 3.7) 0.0 (NA)
40-59 99.2 (98.8, 99.5) 0.8 (0.5, 1.2) 98.4 (97.6, 99.0) 1.6 (1.0, 2.4) 0.0 (NA)
>=60 99.6 (99.0, 99.8) 0.4 (0.2, 1.0) 99.1 (98.0, 99.6) 0.9 (0.4, 2.0) 0.0 (NA)

By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)
Genotype
% (95% CI)
rs169097 C T CC CT TT
Non-Hispanic White Male 99.6 (99.3, 99.8) 0.4 (0.2, 0.7) 99.3 (98.7, 99.6) 0.7 (0.3, 1.3) 0.0 (0.0, 0.3)
Female 99.8 (99.3, 99.9) 0.2 (0.1, 0.7) 99.6 (98.7, 99.9) 0.4 (0.1, 1.3) 0.0 (NA)
Non-Hispanic Black Male 82.6 (79.9, 85.0) 17.4 (15.0, 20.1) 68.4 (63.9, 72.5) 28.4 (24.5, 32.7) 3.2 (1.9, 5.3)
Female 83.1 (80.7, 85.2) 16.9 (14.8, 19.3) 68.4 (64.1, 72.3) 29.4 (25.6, 33.5) 2.2 (1.6, 3.2)
Mexican American Male 98.8 (97.9, 99.3) 1.2 (0.7, 2.1) 97.5 (95.9, 98.6) 2.5 (1.4, 4.1) 0.0 (NA)
Female 99.3 (98.7, 99.6) 0.7 (0.4, 1.3) 98.6 (97.5, 99.3) 1.4 (0.7, 2.5) 0.0 (NA)

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Page last reviewed: March 16, 2009 (archived document)