CAT Allele and Genotype Frequencies



Available polymorphism(s)

Common Designations

rs number

Nucleotide change Amino acid change

Genotyping method

rs769214

-843A>G TaqMan


By Race/Ethnicity

Variant Race-ethnicity Allele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs769214 A G AA AG GG
Non-Hispanic White 66.1 (63.4, 68.7) 33.9 (31.3, 36.6) <0.001 43.6 (40.0, 47.2) 45.0 (42.5, 47.6) 11.4 (9.4, 13.7) <0.001 0.68
Non-Hispanic Black 58.8 (57.0, 60.6) 41.2 (39.4, 43.0) 35.0 (32.5, 37.6) 47.6 (44.8, 50.3) 17.4 (15.6, 19.4) 0.82
Mexican American 49.7 (48.8, 50.6) 50.3 (49.4, 51.2) 24.0 (22.0, 26.1) 51.5 (47.4, 55.5) 24.6 (22.3, 27.0) 0.32
Total* 62.4 (60.0, 64.7) 37.6 (35.3, 40.0) 39.5 (36.3, 42.7) 45.8 (43.4, 48.2) 14.8 (13.0, 16.7)

* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

Variant Age (years) Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs769214 A G AA AG GG
12-19 63.4 (59.0, 67.5) 36.6 (32.5, 41.0) 0.498 39.5 (34.3, 44.9) 47.8 (43.7, 51.9) 12.7 (9.2, 17.2) 0.145
20-39 61.0 (57.6, 64.3) 39.0 (35.7, 42.4) 38.4 (33.0, 44.2) 45.1 (39.9, 50.5) 16.4 (14.3, 18.8)
40-59 62.6 (57.6, 67.3) 37.4 (32.7, 42.4) 39.1 (33.0, 45.6) 46.9 (42.3, 51.6) 14.0 (10.3, 18.7)
>=60 64.0 (62.1, 65.9) 36.0 (34.1, 37.9) 42.0 (39.2, 44.9) 44.0 (41.5, 46.6) 14.0 (12.5, 15.6)
Total 62.4 (60.0, 64.7) 37.6 (35.3, 40.0) 39.5 (36.3, 42.7) 45.8 (43.4, 48.2) 14.8 (13.0, 16.7)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

Variant Sex Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs769214 A G AA AG GG
Male 63.0 (59.2, 66.7) 37.0 (33.3, 40.8) 0.471 40.4 (35.5, 45.5) 45.2 (41.1, 49.4) 14.4 (11.3, 18.1) 0.747
Female 61.8 (59.8, 63.6) 38.2 (36.4, 40.2) 38.6 (35.9, 41.4) 46.3 (43.7, 48.9) 15.1 (13.4, 16.9)
Total 62.4 (60.0, 64.7) 37.6 (35.3, 40.0) 39.5 (36.3, 42.7) 45.8 (43.4, 48.2) 14.8 (13.0, 16.7)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)
Genotype
% (95% CI)
rs769214 A G AA AG GG
Non-Hispanic White 12-19 67.9 (61.6, 73.5) 32.1 (26.5, 38.4) 44.8 (37.2, 52.7) 46.1 (40.8, 51.5) 9.1 (5.2, 15.4)
20-39 65.8 (61.2, 70.2) 34.2 (29.8, 38.8) 43.8 (36.7, 51.2) 44.0 (37.5, 50.8) 12.2 (9.4, 15.6)
40-59 65.0 (58.9, 70.7) 35.0 (29.3, 41.1) 41.6 (33.9, 49.7) 46.9 (41.1, 52.7) 11.6 (7.5, 17.3)
>=60 67.1 (65.2, 68.8) 32.9 (31.2, 34.8) 45.2 (42.5, 47.9) 43.8 (41.1, 46.5) 11.1 (9.5, 12.8)
Non-Hispanic Black 12-19 58.3 (55.7, 60.8) 41.7 (39.2, 44.3) 31.8 (27.1, 36.8) 53.0 (46.0, 59.8) 15.2 (11.9, 19.3)
20-39 58.2 (55.4, 61.0) 41.8 (39.0, 44.6) 34.9 (31.9, 37.9) 46.7 (43.0, 50.5) 18.4 (15.0, 22.4)
40-59 60.6 (56.8, 64.2) 39.4 (35.8, 43.2) 36.7 (31.6, 42.2) 47.7 (42.5, 52.9) 15.6 (12.2, 19.6)
>=60 58.1 (52.9, 63.2) 41.9 (36.8, 47.1) 36.8 (30.1, 44.1) 42.6 (36.0, 49.6) 20.5 (15.8, 26.2)
Mexican American 12-19 51.5 (48.0, 55.1) 48.5 (44.9, 52.0) 23.6 (17.6, 30.8) 55.9 (47.8, 63.7) 20.5 (17.1, 24.4)
20-39 49.6 (47.5, 51.7) 50.4 (48.3, 52.5) 23.6 (20.0, 27.5) 52.1 (46.4, 57.7) 24.3 (21.2, 27.8)
40-59 48.1 (43.8, 52.4) 51.9 (47.6, 56.2) 24.6 (19.5, 30.4) 47.0 (40.4, 53.8) 28.4 (23.2, 34.3)
>=60 50.1 (45.6, 54.7) 49.9 (45.3, 54.4) 25.9 (19.8, 33.2) 48.3 (42.0, 54.7) 25.7 (21.9, 30.0)

By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)
Genotype
% (95% CI)
rs769214 A G AA AG GG
Non-Hispanic White Male 66.8 (62.7, 70.8) 33.2 (29.2, 37.3) 44.3 (38.7, 50.1) 45.1 (40.1, 50.1) 10.6 (7.6, 14.8)
Female 65.4 (63.1, 67.7) 34.6 (32.3, 36.9) 42.9 (39.5, 46.4) 45.0 (42.1, 47.9) 12.1 (10.4, 14.0)
Non-Hispanic Black Male 60.3 (56.9, 63.7) 39.7 (36.3, 43.1) 38.0 (33.8, 42.4) 44.7 (41.4, 48.0) 17.4 (14.4, 20.7)
Female 57.6 (55.2, 59.9) 42.4 (40.1, 44.8) 32.6 (29.9, 35.4) 50.0 (47.0, 53.0) 17.4 (14.8, 20.5)
Mexican American Male 49.5 (47.8, 51.2) 50.5 (48.8, 52.2) 24.5 (22.9, 26.2) 50.0 (47.0, 53.0) 25.5 (22.9, 28.3)
Female 49.9 (48.1, 51.7) 50.1 (48.3, 51.9) 23.4 (19.6, 27.7) 53.0 (46.9, 59.1) 23.6 (20.7, 26.6)

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Page last reviewed: March 16, 2009 (archived document)