ALAD Allele and Genotype Frequencies



Available polymorphism(s)

Common Designations

rs number

Nucleotide change Amino acid change

Genotyping method

rs1800435

Ex4+13G>C G177C Lys68Asn Lys88Asn TaqMan

 


By Race/Ethnicity

Variant Race-ethnicity Allele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1800435 C G CC CG GG
Non-Hispanic White 8.1 (7.0, 9.3) 91.9 (90.7, 93.0) <0.001 0.6 (0.3, 1.2) 15.1 (13.3, 17.0) 84.4 (82.2, 86.3) <0.001 0.63
Non-Hispanic Black 1.3 (1.0, 1.9) 98.7 (98.1, 99.0) 0.0 (NA) 2.7 (1.9, 3.7) 97.3 (96.3, 98.1) 0.48
Mexican American 4.5 (3.6, 5.5) 95.5 (94.5, 96.4) 0.3 (0.1, 1.0) 8.4 (6.8, 10.5) 91.3 (89.3, 93.0) 0.69
Total* 6.5 (5.7, 7.4) 93.5 (92.6, 94.3) 0.4 (0.2, 0.9) 12.2 (10.9, 13.6) 87.4 (85.9, 88.8)

* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

Variant Age (years) Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1800435 C G CC CG GG
12-19 6.4 (4.3, 9.4) 93.6 (90.6, 95.7) 0.196 0.6 (0.1, 2.3) 11.7 (7.9, 16.8) 87.7 (82.3, 91.7) 0.218
20-39 5.5 (4.5, 6.7) 94.5 (93.3, 95.5) 0.4 (0.1, 1.6) 10.2 (8.3, 12.5) 89.4 (87.1, 91.2)
40-59 7.4 (5.8, 9.4) 92.6 (90.6, 94.2) 0.4 (0.1, 1.1) 14.0 (11.1, 17.6) 85.6 (81.9, 88.7)
>=60 7.3 (5.9, 9.0) 92.7 (91.0, 94.1) 0.5 (0.2, 1.6) 13.6 (11.1, 16.6) 85.8 (82.7, 88.5)
Total 6.5 (5.7, 7.4) 93.5 (92.6, 94.3) 0.4 (0.2, 0.9) 12.2 (10.9, 13.6) 87.4 (85.9, 88.8)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

Variant Sex Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1800435 C G CC CG GG
Male 6.5 (5.3, 7.9) 93.5 (92.1, 94.7) 0.903 0.7 (0.3, 1.6) 11.6 (9.7, 13.7) 87.8 (85.4, 89.8) 0.156
Female 6.6 (5.7, 7.6) 93.4 (92.4, 94.3) 0.2 (0.1, 0.6) 12.7 (11.0, 14.6) 87.1 (85.2, 88.8)
Total 6.5 (5.7, 7.4) 93.5 (92.6, 94.3) 0.4 (0.2, 0.9) 12.2 (10.9, 13.6) 87.4 (85.9, 88.8)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)
Genotype
% (95% CI)
rs1800435 C G CC CG GG
Non-Hispanic White 12-19 8.9 (6.0, 13.1) 91.1 (86.9, 94.0) 0.8 (0.2, 3.5) 16.2 (10.9, 23.4) 82.9 (75.5, 88.5)
20-39 6.8 (5.5, 8.4) 93.2 (91.6, 94.5) 0.5 (0.1, 2.5) 12.6 (10.3, 15.4) 86.9 (84.0, 89.3)
40-59 9.0 (6.9, 11.6) 91.0 (88.4, 93.1) 0.5 (0.2, 1.4) 17.0 (13.3, 21.6) 82.5 (77.7, 86.4)
>=60 8.5 (6.9, 10.5) 91.5 (89.5, 93.1) 0.6 (0.2, 1.9) 15.9 (12.9, 19.5) 83.5 (79.8, 86.6)
Non-Hispanic Black 12-19 1.2 (0.7, 2.1) 98.8 (97.9, 99.3) 0.0 (NA) 2.3 (1.3, 4.1) 97.7 (95.9, 98.7)
20-39 1.6 (1.0, 2.5) 98.4 (97.5, 99.0) 0.0 (NA) 3.1 (2.0, 4.9) 96.9 (95.1, 98.0)
40-59 1.1 (0.6, 1.9) 98.9 (98.1, 99.4) 0.0 (NA) 2.1 (1.2, 3.8) 97.9 (96.2, 98.8)
>=60 1.4 (0.6, 2.8) 98.6 (97.2, 99.4) 0.0 (NA) 2.7 (1.3, 5.6) 97.3 (94.4, 98.7)
Mexican American 12-19 4.5 (3.1, 6.6) 95.5 (93.4, 96.9) 0.4 (0.1, 3.5) 8.2 (5.1, 12.9) 91.4 (87.1, 94.3)
20-39 4.8 (3.7, 6.3) 95.2 (93.7, 96.3) 0.3 (0.1, 1.1) 9.1 (6.8, 12.1) 90.6 (87.7, 92.9)
40-59 4.4 (3.0, 6.4) 95.6 (93.6, 97.0) 0.2 (0.0, 1.5) 8.4 (5.6, 12.3) 91.4 (87.5, 94.2)
>=60 2.6 (1.6, 4.3) 97.4 (95.7, 98.4) 0.0 (NA) 5.3 (3.2, 8.6) 94.7 (91.4, 96.8)

By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)
Genotype
% (95% CI)
rs1800435 C G CC CG GG
Non-Hispanic White Male 8.0 (6.4, 10.0) 92.0 (90.0, 93.6) 0.9 (0.4, 2.3) 14.2 (11.8, 17.1) 84.8 (81.5, 87.6)
Female 8.1 (7.0, 9.4) 91.9 (90.6, 93.0) 0.2 (0.1, 0.7) 15.8 (13.8, 18.1) 84.0 (81.6, 86.1)
Non-Hispanic Black Male 1.6 (0.9, 2.7) 98.4 (97.3, 99.1) 0.0 (NA) 3.2 (1.9, 5.4) 96.8 (94.6, 98.1)
Female 1.1 (0.7, 1.8) 98.9 (98.2, 99.3) 0.0 (NA) 2.3 (1.4, 3.6) 97.7 (96.4, 98.6)
Mexican American Male 4.8 (4.0, 5.8) 95.2 (94.2, 96.0) 0.2 (0.0, 1.3) 9.3 (7.3, 11.6) 90.6 (88.4, 92.4)
Female 4.2 (3.0, 5.7) 95.8 (94.3, 97.0) 0.4 (0.1, 1.2) 7.6 (5.5, 10.3) 92.1 (89.2, 94.2)

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Page last reviewed: March 16, 2009 (archived document)