ADRB3 Allele and Genotype Frequencies



Available polymorphism(s)

Common Designations

rs number

Nucleotide change Amino acid change

Genotyping method

rs4994

Ex1+387T>C Trp64Arg TaqMan

 


By Race/Ethnicity

Variant Race-ethnicity Allele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs4994 C T CC CT TT
Non-Hispanic White 6.9 (5.9, 8.0) 93.1 (92.0, 94.1) <0.001 0.6 (0.3, 1.1) 12.5 (10.8, 14.4) 86.9 (84.8, 88.7) <0.001 0.27
Non-Hispanic Black 11.7 (10.3, 13.1) 88.3 (86.9, 89.7) 1.4 (0.8, 2.5) 20.5 (18.4, 22.7) 78.1 (75.7, 80.3) 0.78
Mexican American 16.6 (14.7, 18.7) 83.4 (81.3, 85.3) 2.7 (1.9, 3.8) 27.7 (24.6, 31.1) 69.5 (65.9, 72.9) 0.82
Total* 8.6 (7.8, 9.5) 91.4 (90.5, 92.2) 0.9 (0.7, 1.2) 15.5 (14.0, 17.0) 83.6 (82.0, 85.2)

* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

Variant Age (years) Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs4994 C T CC CT TT
12-19 9.4 (6.9, 12.7) 90.6 (87.3, 93.1) 0.278 0.7 (0.3, 1.5) 17.4 (12.6, 23.6) 81.9 (75.5, 86.8) 0.016
20-39 8.8 (7.4, 10.5) 91.2 (89.5, 92.6) 0.9 (0.5, 1.5) 15.9 (13.1, 19.1) 83.3 (80.0, 86.1)
40-59 9.2 (7.5, 11.1) 90.8 (88.9, 92.5) 1.4 (0.9, 2.1) 15.6 (12.7, 18.9) 83.0 (79.5, 86.1)
>=60 7.0 (6.2, 7.9) 93.0 (92.1, 93.8) 0.5 (0.2, 1.0) 13.0 (11.5, 14.7) 86.5 (84.8, 88.0)
Total 8.6 (7.8, 9.5) 91.4 (90.5, 92.2) 0.9 (0.7, 1.2) 15.5 (14.0, 17.0) 83.6 (82.0, 85.2)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

Variant Sex Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs4994 C T CC CT TT
Male 8.3 (7.1, 9.7) 91.7 (90.3, 92.9) 0.464 0.9 (0.6, 1.5) 14.8 (12.6, 17.4) 84.3 (81.6, 86.6) 0.736
Female 8.9 (7.9, 10.1) 91.1 (89.9, 92.1) 0.9 (0.6, 1.2) 16.1 (14.1, 18.2) 83.0 (80.8, 85.0)
Total 8.6 (7.8, 9.5) 91.4 (90.5, 92.2) 0.9 (0.7, 1.2) 15.5 (14.0, 17.0) 83.6 (82.0, 85.2)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)
Genotype
% (95% CI)
rs4994 C T CC CT TT
Non-Hispanic White 12-19 6.0 (3.5, 10.2) 94.0 (89.8, 96.5) 0.4 (0.0, 3.2) 11.2 (6.5, 18.7) 88.4 (80.6, 93.3)
20-39 7.0 (5.3, 9.1) 93.0 (90.9, 94.7) 0.6 (0.2, 1.5) 12.9 (9.8, 16.8) 86.6 (82.6, 89.8)
40-59 7.5 (5.5, 10.1) 92.5 (89.9, 94.5) 0.9 (0.3, 2.4) 13.2 (9.6, 17.9) 85.9 (81.0, 89.7)
>=60 6.3 (5.5, 7.2) 93.7 (92.8, 94.5) 0.5 (0.2, 1.2) 11.5 (10.1, 13.2) 87.9 (86.3, 89.4)
Non-Hispanic Black 12-19 11.2 (8.9, 14.0) 88.8 (86.0, 91.1) 0.8 (0.4, 1.3) 20.8 (16.4, 26.1) 78.4 (73.0, 83.0)
20-39 11.6 (9.4, 14.1) 88.4 (85.9, 90.6) 1.6 (0.8, 3.2) 20.0 (16.9, 23.6) 78.4 (74.3, 82.0)
40-59 12.6 (10.3, 15.3) 87.4 (84.7, 89.7) 2.4 (1.0, 5.6) 20.4 (16.1, 25.4) 77.3 (72.6, 81.3)
>=60 11.0 (9.4, 12.9) 89.0 (87.1, 90.6) 0.2 (0.0, 1.4) 21.7 (18.1, 25.7) 78.2 (74.3, 81.6)
Mexican American 12-19 19.8 (17.1, 22.8) 80.2 (77.2, 82.9) 4.1 (2.4, 7.0) 31.4 (25.7, 37.8) 64.5 (58.8, 69.7)
20-39 15.6 (13.0, 18.5) 84.4 (81.5, 87.0) 2.4 (1.5, 3.7) 26.4 (21.9, 31.5) 71.2 (65.9, 76.0)
40-59 16.5 (15.1, 17.9) 83.5 (82.1, 84.9) 2.4 (1.3, 4.3) 28.2 (25.1, 31.6) 69.4 (66.6, 72.0)
>=60 15.1 (12.4, 18.2) 84.9 (81.8, 87.6) 2.4 (1.5, 3.9) 25.3 (20.5, 30.8) 72.3 (66.6, 77.3)

By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)
Genotype
% (95% CI)
rs4994 C T CC CT TT
Non-Hispanic White Male 6.8 (5.3, 8.6) 93.2 (91.4, 94.7) 0.7 (0.3, 1.6) 12.1 (9.4, 15.5) 87.1 (83.7, 89.9)
Female 6.9 (5.8, 8.2) 93.1 (91.8, 94.2) 0.5 (0.2, 1.1) 12.8 (10.7, 15.3) 86.7 (84.2, 88.9)
Non-Hispanic Black Male 11.9 (10.0, 14.0) 88.1 (86.0, 90.0) 1.8 (0.8, 3.8) 20.2 (17.0, 23.8) 78.0 (74.4, 81.3)
Female 11.5 (10.1, 13.1) 88.5 (86.9, 89.9) 1.1 (0.5, 2.3) 20.7 (18.7, 22.9) 78.2 (75.6, 80.5)
Mexican American Male 17.8 (15.8, 19.9) 82.2 (80.1, 84.2) 3.1 (2.0, 4.9) 29.3 (25.9, 33.0) 67.6 (63.9, 71.0)
Female 15.4 (13.3, 17.7) 84.6 (82.3, 86.7) 2.3 (1.4, 3.9) 26.1 (22.2, 30.4) 71.6 (67.4, 75.5)

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Page last reviewed: March 16, 2009