Integrating Genome Sequencing in Health Care Systems: Evaluation, Implementation, and Population Health Impact
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- Precision Medicine and Population Health Interest Group, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health
- Center for Translation Research and Implementation Science, National Heart, Lung and Blood Institute, National Institutes of Health
- Office of Public Health Genomics, Centers for Disease Control and Prevention
February 14, 2018, 2:00-3:00 pm EST
NCI Shady Grove Campus, Room 2E032/034
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Human genome sequencing is increasingly used in a variety of health systems in the United States and globally. Clinical screening programs share the goal of examining genes or variants in unselected populations to identify individuals at increased risk to help prevent future disease, or adverse drug outcomes. Many current genomic-based screening programs examine germline variability in specific genes that have been evaluated and recommended by evidence groups. Others are implementing whole genome or whole exome sequencing as part of biobank efforts linked with electronic health records and/or other epidemiologic data.
- Presentations. Each presenter will review current experiences; and evidentiary, economic, data sharing and infrastructure, and outcome data requirements needed to implement and measure success of genome sequencing in improving health. (20 minutes each; 40 minutes total)
- Discussion and Q&As. Emphasis is on how the presented information should inform an implementation science agenda in genomic medicine. (20 minutes)
Integrating Genomics into Large Health Systems: Challenges in Implementation and Evaluation
GREGORY FEERO, MD, PhD
Faculty, Maine Dartmouth Family Medicine Residency Program, Augusta, Maine
Associate Editor for Genomics, the Journal of the American Medical Association
Recent Relevant Publications:
- Seven Questions for Personalized MedicineExternal. Joyner MJ, Paneth N. JAMA. 2015 Sep 8;314(10):999-1000.
- The Impact of Whole-Genome Sequencing on the Primary Care and Outcomes of Healthy Adult Patients: A Pilot Randomized Trial.External Vassy JL, et al. Ann Intern Med. 2017 Jun 27.
- The IGNITE network: a model for genomic medicine implementation and research.External Weitzel KW, et al. BMC Med Genomics. 2016 Jan 5;9:1
Integrating Genomics into Large Health Systems: The Geisinger Experience
MICHAEL MURRAY, MD
Director of Clinical Genomics, Geisinger Health System
Recent Relevant Publications:
- Genetic identification of familial hypercholesterolemia within a single U.S. health care system.External Abul-Husn NS, et al. Science. 2016 Dec 23;354(6319).
- Early cancer diagnoses through BRCA1/2 screening of unselected adult biobank participants. External Buchanan AH, et al. Genet Med. 2017;October 26
- Medicine’s future? External Trivedi BP. Science. 2017 Oct 27;358(6362):436-440.