Host Genomics and COVID-19: Implications for Clinical and Public Health Practice

October 6, 2022, 11:00 am -12:00 noon ET

Early in the COVID-19 pandemic, we explored the rationale for host genomic studies to our understanding of COVID-19 occurrence and outcomes. More than two years into the pandemic, many academic research groups and consortia have launched worldwide open-science collaborations, featuring shared resources and rapid dissemination of research findings. Large-scale studies, encompassing both rare inborn errors of immunity, and common genetic variants, have used different study designs and multiple disease phenotype definitions to identify several genomic regions associated with COVID-19. Along with multiple follow-up studies, these findings have increased our understanding of disease etiology and provided routes for management of COVID-19.  Emerging opportunities include the clinical translatability of genetic risk prediction, the repurposing of existing drugs, exploration of variable host effects of different viral strains, study of inter-individual variability in vaccination response and understanding the long-term consequences of SARS-CoV-2 infection.

This seminar will review our emerging knowledge of the role of host genomic factors in the susceptibility and outcomes of COVID-19 infection, response to vaccines and treatments as well as long-term sequels of the disease. Our speakers will discuss implications of such knowledge for clinical and public health practice and how this information could be used in the control of the pandemic, and more generally in the control of infectious diseases.

Jean-Laurent Casanova
Jean-Laurent Casanova, M.D., Ph.D.

Levy Family Professor, Howard Hughes Senior Attending Physician,
Rockefeller University, New York, New York

Jacques Fellay
Jacques Fellay, M.D., Ph.D.

Associate professor
Swiss Institute of Bioinfomatics
École Polytechnique Fédérale de Lausanne
Lausanne, Switzerland

Selected References

  1. Host genomics and COVID-19: Two Years Later. Drzymalla E et al, CDC Blog Post, May 2022.
  2. Human genetic and immunological determinants of critical COVID-19 pneumonia. Zhang Q et al. 2022 Mar;603(7902):587-598.
  3. A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection. Andreakos E, et al. Nat Immunol. 2022 Feb;23(2):159-164.
  4. The intersection of genetics and COVID-19 in 2021: preview of the 2021 Rodney Howell Symposium. Rasmussen SA et al. Genet Med. 2021 Jun;23(6):1001-1003.
  5. The human genetic epidemiology of COVID-19. Niemi MEK et al, Nature Rev Genetics, May 2022.

Hosted by

  • Office of Genomics and Precision Public Health, Office of Science