If you have already had colorectal cancer

Test Result Result Meaning What it means for you What it means for your family
If you have already colorectal cancer what the test results mean to you and your family 
Positive You have a mutation known to cause hereditary colorectal cancer. Medical options are available to reduce your future cancer risk or find cancer early. Family members who have genetic testing should test for the same mutation you have.
Negative The test did not find a mutation that increases your risk for cancer. The test did not find a mutation that caused your cancer. Further testing may be available. Genetic testing in your family members is unlikely to be helpful unless another family member has had colorectal cancer or has a known mutation.
Negative genetic test, but abnormal tumor screening Although the test did not find a mutation, you could still have Lynch syndrome. Medical options are available to reduce your future cancer risk or find cancer early. Genetic testing in your family members is unlikely to be helpful unless another family member has had colorectal cancer, or has a known mutation.
Variant of Unknown Significance (VUS) The test found a mutation in one of the genes associated with Lynch syndrome, but whether that specific mutation causes cancer is unknown. You are still considered at increased risk for cancers, and medical options are available for prevention. Family members typically should not be tested for a VUS until we learn whether or not it causes cancer.
Page last reviewed: September 13, 2018