Ethylene Oxide Hemoglobin Adducts

CDC routinely updates summary measurements for NHANES biomonitoring data in Updated Tables to the National Report on Human Exposure to Environmental Chemicals; these updates typically occur every 12-18 months.

CDC is providing these ethylene oxide hemoglobin adduct measurements as a standalone resource in advance of the next scheduled National Report update to aid federal, state, and local public health agencies, and others, currently investigating ethylene oxide.

These tables present biomonitoring data gathered in two cycles of CDC’s National Health and Nutrition Examination Survey (NHANES): survey years 2013-14 and 2015-16.  The NHANES survey is designed to provide nationally representative information for the general U.S. population.

Ethylene oxide hemoglobin adducts were measured in blood from random subsamples of NHANES participants. Hemoglobin adducts were used as a marker of exposure for this chemical substance.  The Environmental Health Laboratory in CDC’s National Center for Environmental Health used mass spectrometry methods to measure ethylene oxide hemoglobin adducts in blood.

The table showing data for the cigarette smoking population from NHANES does not include a breakdown by race or ethnicity because the available sample size could not produce reliable estimates.

The measurement of an environmental chemical in a person’s blood or urine is a measure of exposure; it does not by itself mean that the chemical causes disease or an adverse effect.  Research studies, separate from these data, are required to determine which blood concentrations are safe and which ones could be associated with disease or an adverse effect.

Please direct any questions about this information to CDC-INFO

https://wwwn.cdc.gov/dcs/contactus/form

Notes and Additional Resources

Statistics include geometric means and selected percentiles, with 95 percent confidence intervals around each estimated statistic. Percentiles describe the shape of the distribution. For all chemicals, the 50th, 75th, 90th, and 95th percentiles are presented.

Biomonitoring is the assessment of human exposure to chemicals by measuring the chemicals, their metabolites, or adducts in human specimens such as blood, serum, or urine.

Ethylene Oxide Hemoglobin Adduct Concentrations Among Non-smokers – National Health and Nutrition Examination Survey, 2013-16

CAS Number 75-21-8
Geometric mean and selected percentiles of hemoglobin adduct concentrations (in pmol/g hemoglobin) for the non-smoking population* from the National Health and Nutrition Examination Survey.
Ethylene Oxide Hemoglobin Adduct (2013 – 2016)
Demographic
(Category)
Survey
Years
Geometric Mean
(95% CI)
50th Percentile
(95% CI)
75th Percentile
(95% CI)
90th Percentile
(95% CI)
95th Percentile
(95% CI)
Sample
Size
Total population 13-14 27.8 (26.3-29.4) 28.3 (26.9-29.7) 36.4 (34.4-38.6) 48.6 (45.4-51.3) 58.9 (54.2-67.5) 1945
Total population 15-16 27.0 (25.4-28.7) 25.8 (24.6-27.0) 33.7 (31.8-35.6) 46.4 (42.7-51.8) 61.8 (52.4-77.6) 1896
Age 6-11 years 13-14 33.0 (30.7-35.3) 32.3 (29.4-35.8) 41.6 (36.8-46.5) 51.0 (47.3-54.5) 61.0 (54.1-73.7) 321
Age 6-11 years 15-16 32.2 (30.9-33.5) 31.3 (29.9-32.8) 38.7 (36.7-40.8) 50.4 (45.2-56.8) 58.4 (54.3-62.2) 301
Age 12-19 years 13-14 28.5 (26.7-30.4) 28.8 (26.7-30.3) 35.4 (33.4-38.8) 47.5 (42.8-55.1) 58.4 (46.6-77.3) 358
Age 12-19 years 15-16 26.9 (24.5-29.5) 26.3 (24.6-28.5) 34.3 (30.4-38.0) 44.9 (39.5-52.3) 52.4 (44.9-58.5) 328
Age 20+ years 13-14 27.1 (25.6-28.7) 27.8 (26.2-29.3) 35.8 (33.6-37.7) 47.7 (43.2-52.5) 58.9 (52.5-67.5) 1266
Age 20+ years 15-16 26.5 (24.8-28.3) 25.0 (23.5-26.5) 32.8 (31.1-35.2) 46.1 (41.8-52.4) 63.8 (52.4-80.1) 1267
Males 13-14 28.3 (26.5-30.1) 29.4 (27.5-30.4) 37.3 (34.9-39.2) 49.0 (44.0-51.3) 58.5 (51.3-68.9) 897
Males 15-16 28.4 (26.8-30.0) 26.6 (25.0-27.9) 35.4 (33.4-36.7) 49.7 (44.4-55.2) 77.6 (58.6-80.4) 882
Females 13-14 27.3 (25.8-29.0) 27.8 (26.2-28.9) 35.6 (33.9-37.5) 48.1 (44.3-53.9) 58.9 (53.0-67.5) 1048
Females 15-16 25.9 (24.1-27.9) 25.1 (23.5-26.6) 32.3 (30.8-34.6) 45.2 (39.3-51.0) 55.2 (47.5-66.0) 1014
Non-Hispanic blacks 13-14 30.5 (28.4-32.8) 30.0 (27.9-32.8) 42.6 (36.9-46.5) 56.5 (50.1-67.0) 75.9 (60.0-105) 376
Non-Hispanic blacks 15-16 31.0 (29.3-32.7) 29.9 (27.3-32.7) 39.4 (36.9-43.1) 52.3 (46.2-61.7) 63.6 (53.5-76.7) 340
Non-Hispanic whites 13-14 26.5 (24.4-28.8) 27.4 (25.5-29.4) 34.9 (31.7-38.0) 46.6 (40.9-51.3) 57.4 (48.1-67.5) 680
Non-Hispanic whites 15-16 25.4 (23.4-27.7) 24.4 (23.0-25.9) 31.3 (28.9-33.3) 41.8 (38.7-47.4) 61.8 (45.0-80.5) 569
All Hispanics 13-14 29.4 (28.1-30.8) 29.2 (28.4-30.4) 36.1 (34.1-38.4) 47.6 (43.1-52.1) 57.4 (51.0-70.8) 585
All Hispanics 15-16 28.3 (27.0-29.6) 26.9 (25.7-28.6) 34.7 (33.1-36.3) 46.0 (40.8-56.5) 60.8 (47.9-92.3) 654
Limit of detection (LOD, see Data Analysis section) for Survey year 13-14 and 15-16 are 12.9 and 12.9 respectively.
*Non-smoking is defined as a serum cotinine concentration of 10 ng/mL or less.

Ethylene Oxide Hemoglobin Adduct Concentrations Among Cigarette Smokers – National Health and Nutrition Examination Survey, 2013-16

CAS Number 75-21-8
Geometric mean and selected percentiles of hemoglobin adduct concentrations (in pmol/g hemoglobin) for the cigarette smoking population* from the National Health and Nutrition Examination Survey.
Ethylene Oxide Hemoglobin Adduct (2013 – 2016)
Demographic
(Category)
Survey
Years
Geometric Mean
(95% CI)
50th Percentile
(95% CI)
75th Percentile
(95% CI)
90th Percentile
(95% CI)
95th Percentile
(95% CI)
Sample
Size
Total population 13-14 193 (171-217) 219 (201-236) 342 (314-378) 508 (448-591) 653 (589-863) 416
Total population 15-16 186 (155-223) 220 (185-249) 361 (298-405) 515 (442-565) 652 (557-773) 377
Age 18-49 years 13-14 191 (170-214) 208 (171-242) 342 (303-385) 517 (424-627) 700 (517-894) 271
Age 18-49 years 15-16 146 (110-195) 174 (131-235) 286 (238-374) 448 (329-565) 565 (431-728) 220
Age 50+ years 13-14 197 (150-259) 235 (177-296) 333 (294-423) 493 (423-652) 635 (432-1210) 145
Age 50+ years 15-16 280 (237-331) 290 (220-368) 429 (362-546) 585 (496-778) 778 (557-1480) 157
Males 13-14 193 (168-222) 207 (176-242) 370 (297-423) 558 (420-721) 717 (558-1020) 231
Males 15-16 171 (129-226) 219 (169-263) 348 (284-431) 522 (437-583) 585 (550-662) 231
Females 13-14 192 (154-240) 222 (179-255) 324 (280-375) 486 (390-627) 629 (473-894) 185
Females 15-16 207 (173-248) 220 (167-257) 370 (286-417) 513 (379-890) 737 (419-1480) 146
Limit of detection (LOD, see Data Analysis section) for Survey year 13-14 and 15-16 are 12.9 and 12.9 respectively.
*Cigarette Smoking is defined as a serum cotinine concentration more than 10 ng/mL in participants from the National Health and Nutrition Examination Survey, excluding those who used other tobacco products.
Page last reviewed: February 5, 2020